Table 44Botulinum toxin type A (Dysport) versus placebo Continence - Clinical study characteristics and clinical summary of findings

No. of studiesDesignTreatment (n)Control (n)ResultsLimitationsInconsistencyIndirectnessImprecisionOther considerationsQuality
Continence
1 [A]RCTBotulinum toxin type A (Dysport)

N=17
Placebo

N=14
Number of days with urinary leakage
The botulinum toxin type A group had significantly fewer days with leakage compared to placebo at 0 to 6 weeks (p<0.001), 7 to 12 weeks (p=0.002) and 13 to 26 weeks (p=0.010)
VS (i)NNN (ii)NLow

VS very serious N none

i

No details of randomisation or allocation concealment, incomplete outcome reporting.

ii

Imprecision could not be assessed – no estimates of effect

[A]

Ehren et al 200762

From: 8, Treatment to improve bladder storage

Cover of Urinary Incontinence in Neurological Disease
Urinary Incontinence in Neurological Disease: Management of Lower Urinary Tract Dysfunction in Neurological Disease.
NICE Clinical Guidelines, No. 148.
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