Table 78GRADE profile - Pelvic floor muscle training versus sham in patients with multiple sclerosis - Clinical study characteristics and clinical summary of findings

Quality assessmentSummary of findings
No of patientsEffectQuality
No of studiesDesignLimitationsInconsistencyIndirectnessImprecisionPelvic floor muscle training Frequency (proportion)/Mean (SD)Control Frequency (proportion)/Mean (SD)RelativeAbsolute
(95% CI)
Frequency of voiding(No. with) (follow-up 12 weeks)
Lucio 20101randomised trialsseriousano serious inconsistencyno serious indirectnessno serious imprecision4/13 (30.8%)14/14
(100%)
RR 0.33 (0.15 to 0.72)670 fewer per 1000 (from 280 fewer to 850 fewer)MODERATE
Urgency of voiding(No. with) (follow-up 12 weeks)
Lucio 20101randomised trialsseriousano serious inconsistencyno serious indirectnessseriousb4/13 (30.8%)14/14
(100%)
RR 0.33 (0.14 to 0.76)670 fewer per 1000 (from 240 fewer to 860 fewer)LOW
Nocturnal enuresis (No. with) (follow-up 12 weeks)
Lucio 20101randomised trialsseriousano serious inconsistencyno serious indirectnessseriousb12/13
(92.3%)
11/14
(78.6%)
RR 1.17 (0.86 to 1.61)134 more per 1000 (from 110 fewer to 479 more)LOW
Incomplete emptying (No. with) (follow-up 12 weeks)
Lucio 20101randomised trialsseriousano serious inconsistencyno serious indirectnessseriousb3/13 (23.1%)7/14 (50%)RR 0.46 (0.15 to 1.42)270 fewer per 1000 (from 425 fewer to 210 more)LOW
Sessions attended (follow-up 12 weeks; Better indicated by higher values)
Lucio 20101randomised trialsseriousano serious inconsistencyno serious indirectnessseriousbMean 21.5
SD (1.8)
21.5 (1.8)MD 0.00 (−1.36 to 1.36)MD 0.00 higher (1.36 lower to 1.36 higher)LOW
a

No details or randomisation or allocation concealment. Single blind (patient blind - patient reported outcomes), no drop-outs reported

b

95%CI crosses the minimally important difference (MID) for either benefit or harm

From: 9, Treatment for stress incontinence

Cover of Urinary Incontinence in Neurological Disease
Urinary Incontinence in Neurological Disease: Management of Lower Urinary Tract Dysfunction in Neurological Disease.
NICE Clinical Guidelines, No. 148.
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