Table 39Fondaparinux vs UFH– Clinical summary of findings

OutcomeFondaparinuxUFHRelative riskAbsolute effectQuality
All cause mortality57/1103
48/1110 (4.3%)1.2 (0.82, 1.74)9 more per 1000 (8 fewer to 32 more)LOW
VTE related mortality16/1103
15/1110 (1.4%)1.07 (0.53, 2.16)1 more per 1000 (6 fewer to 16 more)LOW
Recurrent VTE rates (all patients)42/1103
0.75 (0.51, 1.12)13 fewer per 1000 (25 fewer to 6 more)LOW
Subgroup: Cancer patients10/112
0.52 (0.26, 1.05)83 fewer per 1000 (127 fewer to 9 more)LOW
Major bleeding (all patients)22/1103
0.85 (0.49, 1.49)4 fewer per 1000 (12 fewer to 11 more)LOW
Subgroup: Cancer patients2/112
0.76 (0.13, 4.48)6 fewer per 1000 (20 fewer to 82 more)LOW
Fatal bleeding3/1103
3.02 (0.31, 28.98)2 more per 1000 (1 fewer to 25 more)VERY LOW

From: 7, Pharmacological interventions

Cover of Venous Thromboembolic Diseases
Venous Thromboembolic Diseases: The Management of Venous Thromboembolic Diseases and the Role of Thrombophilia Testing [Internet].
NICE Clinical Guidelines, No. 144.
National Clinical Guideline Centre (UK).
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