Table 6.9GRADE summary of findings for the diagnosis of viable intrauterine pregnancy using two or more hCG measurements plus progesterone

Number of studiesNumber of womenMeasure of diagnostic accuracyQuality
Sensitivity % (95% CI)Specificity % (95% CI)Positive predictive value % (95% CI)Negative predictive value % (95% CI)Positive likelihood ratio (95% CI)Negative likelihood ratio (95% CI)
Normal hCG score and progesterone > 30 nmol/l
1 study

(Hahlin et al., 1991)
30793.2

(87.4 to 99.0)*
94.4

(91.5 to 97.4)*
84.0

(76.0 to 91.9)*
97.8

(95.9 to 99.7)*
16.77

(9.85 to 28.54)*
0.07

(0.03 to 0.17)*
Low

CI confidence interval, hCG β-human chorionic gonadotrophin

*

Calculated by NCC-WCH technical team

From: 6, Diagnosis of ectopic pregnancy and miscarriage

Cover of Ectopic Pregnancy and Miscarriage
Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in Early Pregnancy of Ectopic Pregnancy and Miscarriage.
NICE Clinical Guidelines, No. 154.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG; 2012 Dec.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

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