Table 6.9GRADE summary of findings for the diagnosis of viable intrauterine pregnancy using two or more hCG measurements plus progesterone

Number of studiesNumber of womenMeasure of diagnostic accuracyQuality
Sensitivity % (95% CI)Specificity % (95% CI)Positive predictive value % (95% CI)Negative predictive value % (95% CI)Positive likelihood ratio (95% CI)Negative likelihood ratio (95% CI)
Normal hCG score and progesterone > 30 nmol/l
1 study

(Hahlin et al., 1991)

(87.4 to 99.0)*

(91.5 to 97.4)*

(76.0 to 91.9)*

(95.9 to 99.7)*

(9.85 to 28.54)*

(0.03 to 0.17)*

CI confidence interval, hCG β-human chorionic gonadotrophin


Calculated by NCC-WCH technical team

From: 6, Diagnosis of ectopic pregnancy and miscarriage

Cover of Ectopic Pregnancy and Miscarriage
Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in Early Pregnancy of Ectopic Pregnancy and Miscarriage.
NICE Clinical Guidelines, No. 154.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG; 2012 Dec.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK []. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.