Table I.6.7GRADE findings for the diagnosis of ectopic pregnancy using two or more hCG measurements plus progesterone (Model M3)

Quality assessmentNumber of womenMeasure of diagnostic accuracyQuality
Number of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsArea under the ROC curve

(95% CI)
Model M3
1 study

(Condous et al., 2004)
Prospective studyserious1no serious inconsistencyserious2,3no serious imprecisionnone195Test set: 0.836 (0.693 to 0.979)

(Other diagnostic accuracy measures not reported and not calculable)
Low

CI confidence interval, hCG β-human chorionic gonadotrophin, ROC receiver operating characteristic

1

Unclear whether those performing the reference test were blinded to the results of the index test

2

Not all participants presented with pain and bleeding

3

Model was designed and tested on a specific inner city population, therefore may not be generalisable

From: Appendix I, GRADE tables

Cover of Ectopic Pregnancy and Miscarriage
Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management in Early Pregnancy of Ectopic Pregnancy and Miscarriage.
NICE Clinical Guidelines, No. 154.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG; 2012 Dec.
Copyright © 2012, National Collaborating Centre for Women's and Children's Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK [www.cla.co.uk]. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.