Discussion with the guideline development group and stakeholders highlighted the limited evidence available in some areas, meriting further research on daily iron and folic acid supplementation in pregnant women, in particular, in the following areas:
- effects of supplementation of vitamins and other minerals in addition to iron and folic acid on maternal and neonatal outcomes;
- side-effects, as they are often poorly defined and reported (e.g. there is no information on intensity or frequency of most side-effects);
- operational issues related to improving delivery and utilization of this intervention;
- effects of this intervention on fetal growth and programming of chronic diseases.
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Guideline: Daily Iron and Folic Acid Supplementation in Pregnant Women. Geneva: World Health Organization; 2012. Implications for future research.