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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet]. York (UK): Centre for Reviews and Dissemination (UK); 1995-.

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Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet].

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Effect of adenotonsillectomy on c-reactive protein levels in children with obstructive sleep apnea: a meta-analysis

Review published: .

Bibliographic details: Ingram DG, Matthews CK.  Effect of adenotonsillectomy on c-reactive protein levels in children with obstructive sleep apnea: a meta-analysis. Sleep Medicine 2013; 14(2): 172-176. [PubMed: 23317933]

Abstract

OBJECTIVE: Children with obstructive sleep apnea syndrome (OSAS) have increased systemic inflammation, as assessed by c-reactive protein (CRP), and are at risk for substantial end-organ damage. Previous studies assessing the effect of adenotonsillectomy (T&A) on CRP in children with OSAS have yielded conflicting results. Therefore, the purpose of the current investigation was to perform a meta-analysis of the effect of T&A on CRP in children with OSAS and explore possible moderating factors.

METHODS: Multiple databases (PubMed, CINAHL, and Cochrane) were searched for relevant studies. Effective size was calculated with standardized mean differences (SMD) and analyzed with random-effects model. Moderators were examined with mixed-effects models.

RESULTS: Overall, T&A significantly reduced CRP (SMD=-0.79, 95% CI -1.33 to -0.25). We found significant between-study heterogeneity (Cochran's Q=54.6, df=7, p<0.001; I2=90.7%, 95% CI 77.5-98.2%; and H2=10.7, 95% CI 4.5-55.7). We did not find evidence of publication bias or significant effects of tested moderators (study year, study size, age, gender, obesity, apnea-hypopnea index, oxygen nadir, pre-surgical CRP, follow-up duration).

CONCLUSIONS: The results of the current study indicate that T&A significantly reduces CRP levels in children with OSAS. Despite the presence of significant between-study heterogeneity, we did not identify any significant moderating factors.

Published by Elsevier B.V.

Copyright © 2014 University of York.
Bookshelf ID: NBK126941

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