Should flupenthixol versus placebo be used for people who self-harm?

Quality assessmentNo. of patientsEffectQualityImportance
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsFlupenthixolPlaceboRelative risk (95% CI)Absolute
Repetition – during 6 months after trial entry
1Randomised trialsNo serious limitations--Serious1None3/14 (21.4%)12/16 (75%)RR 0.29 (0.1 to 0.81)533 fewer per 1000 (from 142 fewer to 675 fewer)--
-75%533 fewer per 1000 (from 142 fewer to 675 fewer)
Compliance
1Randomised trialsNo serious limitations---None14/18 (77.8%)16/19 (84.2%)Not pooledNot pooled--
-84.2%Not pooled
1

Total sample size is smaller than 300

From: Appendix 17, GRADE evidence profiles

Cover of Self-Harm: Longer-Term Management
Self-Harm: Longer-Term Management.
NICE Clinical Guidelines, No. 133.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2012.
Copyright © 2012, The British Psychological Society & The Royal College of Psychiatrists.

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