Table 99Deterministic base-case cost–utility results

Independent LOSVAS-dependent LOS
Single complication rate
(Scenario 1A)
Dynamic Complications
(Scenario 1B)
Single complication rate
(Scenario 2A)
Dynamic Complications
(Scenario 2B)
C-IVPCAΔC-IVPCAΔC-IVPCAΔC-IVPCAΔ
Costs
 Acute episode:
  Inpatient care£4,301£3,043−£1,258£4,270£2,974−£1,296£1,106£929−£178£909£712−£197
  PCA consumables£0.00£32.14£32.14£0.00£31.54£31.54£0.00£15.78£15.78£0.00£13.87£13.87
  Morphine£26.00£3.30−£22.70£26.00£3.30−£22.70£27.00£18.84−£8.16£27.00£18.84−£8.16
  Subtotal£4,327£3,078−£1,249£4,296£3,009−£1,287£1,133£963−£170£936£745−£191
 Long-term costs:
  Stroke rehabilitation£532.69£532.69£0.00£134.29£92.52−£41.76£532.69£532.69£0.00£58.46£44.63−£13.83
Total£4,860£3,611−£1,249£4,431£3,102−£1,329£1,666£1,496−£170£994£789−£205
Effects
 Episodes of ACS6.26%6.26%1.58%1.09%6.26%6.26%0.69%0.52%
 Strokes0.23%0.23%0.06%0.04%0.23%0.23%0.03%0.02%
 Deaths0.18%0.18%0.05%0.03%0.18%0.18%0.02%0.02%
 Mean LOS (days)9.4406.6789.3726.5282.4282.0381.9941.562
 QALYs:
  Acute episode0.0620.0630.0020.0620.0640.0020.0620.0630.0020.0630.0640.002
  Subsequent LE (discounted)13.02913.0290.00013.04013.0420.00113.02913.0290.00013.04313.0430.000
Total13.09013.0920.00213.10313.1060.00313.09013.0920.00213.10513.1070.002
ICERPCA dominatesPCA dominatesPCA dominatesPCA dominates
Incremental NMB:
 WTP=£20, 000/QALY£1,282.04£1,388.03£202.27£245.81
 WTP=£30, 000/QALY£1,298.60£1,417.62£218.43£266.28

From: Appendix F, Full health economic report

Cover of Sickle Cell Acute Painful Episode
Sickle Cell Acute Painful Episode: Management of an Acute Painful Sickle Cell Episode in Hospital.
NICE Clinical Guidelines, No. 143.
Centre for Clinical Practice at NICE (UK).
Copyright © 2012, National Institute for Health and Clinical Excellence.

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