Table 103LMWH: summary of cost–utility results (mean estimates) from probabilistic sensitivity analysis

Independent LOSVAS-dependent LOSAll four scenarios combined
Single complication rate
(Scenario 1A)
Dynamic Complications
(Scenario 1B)
Single complication rate
(Scenario 2A)
Dynamic Complications
(Scenario 2B)
C–IV
 Costs (95%CI)£5733 (£5258, £6370)£5610 (£5182, £6124)£1283 (£906, £2045)£917 (£735, £1194)£3386 (£799, £6139)
 QALYs (95%CI)12.998 (10.651, 14.758)13.019 (10.685, 14.797)13.007 (10.714, 14.812)13.018 (10.689, 14.771)13.010 (10.685, 14.781)
LMWH
 Costs (95%CI)£3614 (£3219, £4286)£3361 (£3081, £3702)£946 (£583, £1700)£539 (£424, £805)£2115 (£448, £3963)
 QALYs (95%CI)13.000 (10.652, 14.759)13.020 (10.687, 14.800)13.008 (10.716, 14.813)13.019 (10.692, 14.772)13.012 (10.687, 14.783)
Incremental
 Costs (95%CI)−£2120 (−£2405, −£1842)−£2249 (−£2553, −£1975)−£337 (−£453, −£56)−£378 (−£531, −£78)−£1271 (−£2448, −£142)
 QALYs (95%CI)0.001 (0.000, 0.001)0.002 (0.001, 0.005)0.001 (0.000, 0.001)0.001 (0.000, 0.003)0.001 (0.000, 0.003)
ICERLMWH dominatesLMWH dominatesLMWH dominatesLMWH dominatesLMWH dominates
Incremental NMB
 £20, 000/QALY (95%CI)£2140 (£1861, £2427)£2289 (£2006, £2615)£357 (£63, £477)£408 (£88, £574)£1298 (£154, £2490)
 £30, 000/QALY (95%CI)£2151 (£1871, £2436)£2308 (£2022, £2645)£367 (£66, £490)£422 (£93, £597)£1312 (£160, £2511)
Probability cost effective
 £20, 000/QALY1.0001.0000.9890.9930.995
 £30, 000/QALY1.0001.0000.9890.9930.996

ICER = incremental cost-effectiveness ratio; LMWH = low-molecular-weight heparin; LOS = length of (hospital) stay; NMB = net monetary benefit; QALY = quality-adjusted life-years; VAS = visual analogue scale

From: Appendix F, Full health economic report

Cover of Sickle Cell Acute Painful Episode
Sickle Cell Acute Painful Episode: Management of an Acute Painful Sickle Cell Episode in Hospital.
NICE Clinical Guidelines, No. 143.
Centre for Clinical Practice at NICE (UK).
Copyright © 2012, National Institute for Health and Clinical Excellence.

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