Table 3.

MELAS: Initial Clinical Manifestation

Initial Symptom(s) or Sign(s) in 60 Individuals 1Number of IndividualsPercent (%)
Seizures1728
Recurrent headaches1728
Gastrointestinal symptoms (recurrent vomiting, anorexia)1525
Limb weakness1118
Short stature/stopped growth1118
Stroke1017
Altered consciousness712
Impaired mentation712
Hearing loss610
Exercise intolerance610
Visual symptom58
Developmental delay35
Fever35
Drop attacks11
Impaired gait11
1.

Affected individuals frequently presented with more than one manifestation.

From: MELAS

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