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Buckley DI, Ansari M, Butler M, et al. The Refinement of Topics for Systematic Reviews: Lessons and Recommendations From the Effective Health Care Program [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jan.

Cover of The Refinement of Topics for Systematic Reviews

The Refinement of Topics for Systematic Reviews: Lessons and Recommendations From the Effective Health Care Program [Internet].

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Appendix BExample of Selected Aspects of a Topic Refinement

Appendix Figure B1. Nomination: The effectiveness of disease-modifying anti-rheumatic drugs in children with juvenile idiopathic arthritis

Appendix Table B1. Changes to elements of the nominated topic with rationale for refinements

Appendix Figure B2. Example analytic framework

Key Questions

KQ1.

Does treatment with any of a variety of disease-modifying anti-rheumatic drugs (DMARDs), alone or in combination, improve health outcomes (i.e. pain control; clinical remission; quality of life; parent/patient global assessment; mortality; function; or growth and development) compared with placebo, NSAIDs and/or corticosteroids, or other DMARDs?

KQ2.

Does treatment with any of a variety of DMARDs, alone or in combination, improve other outcomes (i.e. active joint count; number of joints with limited ROM; laboratory measures of inflammation; physician global assessment; or radiographic change) compared with placebo, nonsteroidal anti-inflammatory drugs (NSAIDs) and/or corticosteroids, or other DMARDs?

KQ3.

Is improvement with other outcomes associated with improvement in health outcomes?

KQ4.

Does treatment with any of a variety of DMARDs, alone or in combination, result in additional troublesome or serious harms compared with placebo, NSAIDs and/or corticosteroids, or other DMARDs?

KQ5.

How do the efficacy, effectiveness, safety or adverse effects of treatment with DMARDs differ between each of the various subtypes of juvenile idiopathic arthritis (JIA)?

Bookshelf ID: NBK121281

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