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Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.

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Table 6.

Treatment of Manifestations in Individuals with Hidrotic Ectodermal Dysplasia 2

Manifestation/
Concern
TreatmentConsiderations/Other
Dystrophic
nails
  • Filing or drilling of hyperkeratotic nails
  • Artificial nails
  • May improve appearance of hands/feet & ↓ trauma from footwear.
  • May be especially helpful to girls & women.
Hypotrichosis
  • Conditioning hair care products may help to manage dry & sparse hair.
  • Wigs or hair weaves for alopecia
  • Use of artificial hair fibers to improve appearance of hair
  • Use of eyebrow tattoos
  • Alopecia improved w/combination of topical minoxidil & tretinoin in a person w/clinical features of HED2. 1
  • Alopecia improved w/topical minoxidil in a child w/hypohidrotic ED. 2
Palmoplantar
hyperkeratosis
  • Bland skin emollients may help soften hyperkeratosis.
  • Keratolytic preparations (containing e.g. urea, salicylic acid, lactic acid) may be helpful.
  • Regular filing or paring of hard skin can ↓ pain & improve function.
Analgesics may be required for painful plantar keratoderma.
1.

A molecular diagnosis of HED2 was not confirmed. The authors also noted that the efficacy and safety of long-term treatment need to be explored further [Melkote et al 2009].

2.

From: Hidrotic Ectodermal Dysplasia 2

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