NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

National Collaborating Centre for Cancer (UK). Colorectal Cancer: The Diagnosis and Management of Colorectal Cancer. Cardiff: National Collaborating Centre for Cancer (UK); 2011 Nov. (NICE Clinical Guidelines, No. 131.)

Cover of Colorectal Cancer

Colorectal Cancer: The Diagnosis and Management of Colorectal Cancer.

Show details

Appendix 1Summary of the 5th edition of the TNM staging system for colorectal cancer and comparison with Dukes’ stage

Tumour

T1the tumour is confined to the submucosa
T2the tumour has grown into (but not through) the muscularis propria
T3the tumour has grown into (but not through) the serosa
T4the tumour has penetrated through the serosa and the peritoneal surface. If extending directly into other nearby structures (such as other parts of the bowel or other organs/body structures) it is classified as T4a. If there is perforation of the bowel, it is classified as T4b.

Nodes

N0*no lymph nodes contain tumour cells
N1^there are tumour cells in up to 3 regional lymph nodes
N2^there are tumour cells in 4 or more regional lymph nodes
*

A tumour nodule in the pericolic or perirectal adipose tissue without evidence of residual lymph node is regarded as a lymph node metastasis if it is >3mm in diameter. If it is <3mm in diameter, it is regarded as discontinuous tumour extension

^

If there are tumour cells in non-regional lymph nodes (i.e. in a region of the bowel with a different pattern of lymphatic drainage to that of the tumour), that is regarded as distant metastasis (pM1)

Metastases

M0no metastasis to distant organs
M1metastasis to distant organs

Dukes’ stage

  • Dukes’ stage A = T1N0M0 or T2N0M0
  • Dukes’ stage B = T3N0M0 or T4N0M0
  • Dukes’ stage C = any T, N1, M0 or any T, N2, M0
  • Dukes’ stage D = any T, any N, M1
Copyright © 2011, National Collaborating Centre for Cancer.
Bookshelf ID: NBK116633

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (2.0M)

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...