Table 10.5Evidence profile for procalcitonin-guided decision making in relation to duration of empirical treatment with ampicillin plus gentamicin in babies with suspected sepsis in the first 3 days of life versus decision making based on conventional laboratory parameters (immature:total (I:T) neutrophil ratio > 0.2 and C-reactive protein > 5 mg/l)

Number of studiesNumber of babiesEffectQuality
Procalcitonin-guided decision makingDecision making using conventional laboratory parametersRelative (95% confidence interval)Absolute (95% confidence interval)
Duration of antibiotic treatment in hours (all babies)
1
(Stocker 2010)
606179.1 versus 101.5
(NR)
P= 0.012
22.4 hours less
(NR)
Low
Duration of antibiotic treatment in hours (babies with proven or probable infection)
1
(Stocker 2010)
912177.8 versus 170.8
(NR)
P=0.504
7 hours more
(NR)
Low
Duration of antibiotic treatment in hours (babies with possible infection)
1
(Stocker 2010)
211983.4 versus 111.5
(NR)
P<0.001
28.4 hours less
(NR)
Low
Duration of antibiotic treatment in hours (babies with infection unlikely)
1
(Stocker 2010)
303046.5 versus 67.4
(NR)
P =0.001
20.9 hours less
(NR)
Low

NR not reported, P probability

See the complete GRADE Table J 10.5

From: 10, Duration of antibiotic treatment

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.