Table 6.25Evidence profile for erythromycin plus co-amoxiclav compared with placebo for women with preterm labour

Number of studiesNumber of babies/womenEffectQuality
Erythromycin plus co- amoxiclavPlaceboRelative (95% confidence interval)Absolute (95% confidence interval)
Positive blood culture if born within 14 days of randomisation
1(Kenyon 2001b)28/1551
RR 1.12 (0.66 to 1.92)*2 more per 1000 (from 5 fewer to 15 more)Low
Proven necrotising enterocolitis
(Kenyon 2001b)
RR 2.76 (0.8804 to 8.6454)*5 more per 1000 (from 0.3 fewer to 23 more)Moderate
Neonatal death
1(Kenyon 2001b)47/1551
RR 1.21 (0.8 to 1.84)*5 more per 1000 (from 5 fewer to 21 more)Moderate
Median gestational age at birth in days
1(Kenyon 2001b)1551a1556aNCMedian difference is 1 day more*High
Any functional impairment at age 7 years of vision, hearing, speaking, ambulation, dexterity, emotion, cognition or pain in children whose mothers had preterm labour
1(Kenyon 2008b)325/769
RR 1.13 (0.9971 to 1.2797)*49 more per 1000 (from 1 more to 105 more)*Moderate

MD mean difference, NC not calculable, RR relative risk


Calculated by the NCC-WCH technical team from data reported in the article


Median gestational age at birth in days (range): Erythromycin and co-amoxiclav group 267 (145 to 312), Placebo only group 266 (155 to 313)

See the complete GRADE Table J 6.25

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.