Table 6.2Evidence profile for intrapartum ampicillin plus gentamicin compared with postpartum ampicillin plus gentamicin in women with chorioamnionitis

Number of studiesNumber of babies/womenEffectQuality
Intrapartum ampicillin plus gentamicinPostpartum ampicillin plus gentamicinRelative (95% confidence interval)Absolute (95% confidence interval)
Early-onset sepsis
1 (Gibbs 1988)0/26
(0%)
4/19
(21.1%)
RR 0.08 (0 to 1.44) *194 fewer per 1000 (from 211 fewer to 93 more)Low
Early-onset pneumonia
1 (Gibbs 1988)0/26
(0%)
2/19
(10.5%)
RR 0.15 (0.01 to 2.92) *89 fewer per 1000 (from 104 fewer to 202 more)Low
Early-onset sepsis or pneumonia
1 (Gibbs 1988)0/264/19RR 0.08 (0 to 1.44) *194 fewer per 1000 (from 211 fewer to 93 more)Low
Mean neonatal hospital stay (days)
1 (Gibbs 1988)2619-MD 1.9 lower (from 3.31 lower to 0.49 lower) *Low

MD mean difference, RR relative risk

*

Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.2

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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