Table 6.2Evidence profile for intrapartum ampicillin plus gentamicin compared with postpartum ampicillin plus gentamicin in women with chorioamnionitis

Number of studiesNumber of babies/womenEffectQuality
Intrapartum ampicillin plus gentamicinPostpartum ampicillin plus gentamicinRelative (95% confidence interval)Absolute (95% confidence interval)
Early-onset sepsis
1 (Gibbs 1988)0/26
RR 0.08 (0 to 1.44) *194 fewer per 1000 (from 211 fewer to 93 more)Low
Early-onset pneumonia
1 (Gibbs 1988)0/26
RR 0.15 (0.01 to 2.92) *89 fewer per 1000 (from 104 fewer to 202 more)Low
Early-onset sepsis or pneumonia
1 (Gibbs 1988)0/264/19RR 0.08 (0 to 1.44) *194 fewer per 1000 (from 211 fewer to 93 more)Low
Mean neonatal hospital stay (days)
1 (Gibbs 1988)2619-MD 1.9 lower (from 3.31 lower to 0.49 lower) *Low

MD mean difference, RR relative risk


Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 6.2

From: 6, Intrapartum antibiotics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.