Table 5.4Evidence profile for diagnostic test accuracy of membership of a risk groupa for predicting morbidity and mortality associated with suspected and presumed infectionb in singleton babies in the first 5 days of life

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
Morbidity associated with suspected infection in babies who survived
1 (Holst 1990)40385.82
(4.71 to 6.93)*
(97.7 to 98.8)*
(2.30 to 4.71)*
(0.95 to 0.97)*
Very low
Morbidity associated with presumed infection in babies who survived
1 (Holst 1990)40380.47
(0.14 to 0.79)*
(99.3 to 99.8)*
(0.40 to 2.47)*
(0.996 to 1.004)*
Very low
Mortality associated with suspected infection
1 (Holst 1990)4066100
(100 to 100)*
(55.8 to 58.8)*
(2.26 to 2.43)*
0.00 or < 0.02*
Very low
Mortality associated with presumed infection (perinatal mortality associated with neonatal sepsis)
1 (Holst 1990)40660.00
(0.00 to 0.00)*
(55.7 to 58.8)*
(1.70 to 1.79)*
Very low

NC not calculable


Calculated by the NCC-WCH technical team from data reported in the article


Risk group defined as babies with one or more of: previous toxaemia (multiparae only); previous baby <2500 g (multiparae only); maternal psychiatric disorders (primiparae only); contracted pelvis or short stature (primiparae only); intrauterine growth restriction (IUGR) in current pregnancy; imminent preterm delivery in current pregnancy; toxaemia in current pregnancy (primiparae only); hydramnios in current pregnancy; not having attended antenatal care in current pregnancy (assessed at term; multiparae only); breech, footling presentation or transverse lie in current pregnancy


Presumed infection defined as administration of antibiotics, even if the diagnosis was not confirmed by microbiological culture

See the complete GRADE Table J 5.4

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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