Table 5.15Evidence profile for validation of diagnostic test accuracy of ≥ 3 clinical signs for predicting blood-culture-positive infection in the first 28 days of life

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
Babies born at any gestational age
1 (Modi 2009)47161.5 (NC)76.2 (NC)2.58* (NC)0.51* (NC)Very low
Preterm babies (born at ≤ 31 weeks’ gestation)
1 (Modi 2009)NR72.2 (NC)69.0 (NC)2.33* (NC)0.40* (NC)Very low

NC not calculable, NR not reported

*

Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 5.15

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.