Table 5.15Evidence profile for validation of diagnostic test accuracy of ≥ 3 clinical signs for predicting blood-culture-positive infection in the first 28 days of life

Number of studiesNumber of babiesSensitivity (95% confidence interval)Specificity (95% confidence interval)Positive likelihood ratio (95% confidence interval)Negative likelihood ratio (95% confidence interval)Quality
Babies born at any gestational age
1 (Modi 2009)47161.5 (NC)76.2 (NC)2.58* (NC)0.51* (NC)Very low
Preterm babies (born at ≤ 31 weeks’ gestation)
1 (Modi 2009)NR72.2 (NC)69.0 (NC)2.33* (NC)0.40* (NC)Very low

NC not calculable, NR not reported


Calculated by the NCC-WCH technical team from data reported in the article

See the complete GRADE Table J 5.15

From: 5, Risk factors for infection and clinical indicators of possible infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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