Table 9.8Evidence profile for gentamicin given every 24 hours (5 mg/kg/dose) compared with gentamicin given every 12 hours (2.5 mg/kg/dose) in babies with suspected early-onset neonatal infection; all babies also received ampicillin (dosage regimen not reported)

Number of studiesNumber of babiesEffectQuality
Gentamicin every 24 hours (5 mg/kg/dose)Gentamicin every 12 hours (2.5 mg/kg/dose)Relative (95% confidence interval)Absolute (95% confidence interval)
Neonatal adverse events
Kidney impairment (assessed by the N-acetyl-D-glucosaminidase:creatinine ratio)
(de Alba Romero 1998)
Trough concentrations > 2.0 microgram/ml before dose on the fourth day of treatment
(de Alba Romero 1998)
RR 0.55 (0.18 to 1.71)*98 fewer per 1000
(179 fewer to 155 more)*
Peak concentrations > 12.0 microgram/ml after dose on the fourth day of treatment
(de Alba Romero 1998)
RR 0.32 (0.01 to 7.66)*21 fewer per 1000
(31 fewer to 208 more)*

NC not calculable, RR relative risk


Calculated by the NCC-WCH technical team

See the complete GRADE Table J 9.8

From: 9, Antibiotics for suspected infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

No part of this publication may be reproduced, stored or transmitted in any form or by any means, without the prior written permission of the publisher or, in the case of reprographic reproduction, in accordance with the terms of licences issued by the Copyright Licensing Agency in the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publisher at the UK address printed on this page.

The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore for general use.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.