Table 9.8Evidence profile for gentamicin given every 24 hours (5 mg/kg/dose) compared with gentamicin given every 12 hours (2.5 mg/kg/dose) in babies with suspected early-onset neonatal infection; all babies also received ampicillin (dosage regimen not reported)

Number of studiesNumber of babiesEffectQuality
Gentamicin every 24 hours (5 mg/kg/dose)Gentamicin every 12 hours (2.5 mg/kg/dose)Relative (95% confidence interval)Absolute (95% confidence interval)
Neonatal adverse events
Kidney impairment (assessed by the N-acetyl-D-glucosaminidase:creatinine ratio)
1
(de Alba Romero 1998)
0/33
(0%)
0/32
(0%)
NCNCLow
Pharmacokinetics
Trough concentrations > 2.0 microgram/ml before dose on the fourth day of treatment
1
(de Alba Romero 1998)
4*/33
(12%)
7*/32
(22%)
RR 0.55 (0.18 to 1.71)*98 fewer per 1000
(179 fewer to 155 more)*
Low
Peak concentrations > 12.0 microgram/ml after dose on the fourth day of treatment
1
(de Alba Romero 1998)
0/33
(0%)
1/32
(3%)
RR 0.32 (0.01 to 7.66)*21 fewer per 1000
(31 fewer to 208 more)*
Low

NC not calculable, RR relative risk

*

Calculated by the NCC-WCH technical team

See the complete GRADE Table J 9.8

From: 9, Antibiotics for suspected infection

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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