Table 13.3Clinical inputs

InputMeanLower 95% CIUpper 95% CISource
Population
Number of live births706,248ONS 2010
Rate of suspected sepsis10%7% (estimate)12% (estimate)Bedford Russell 2010; Luck 2003
Term babies93.2%HSCIC 2011
Incidence of infection
Term incidence of early-onset GBS0.38 per 1000 live births0.330.42Colbourn 2007
Preterm incidence of early-onset GBS1.84 per 1000 live births1.532.19Colbourn 2007
Term incidence of early-onset non GBS0.5 per 1000 live births0.360.65Colbourn 2007
Preterm incidence of early-onset non GBS6.97 per 1000 live births5.199.01Colbourn 2007
Early-onset GBS preterm meningitis10.1%5.6%15.6%Colbourn 2007
Early-onset GBS term meningitis11.9%8.1%16.4%Colbourn 2007
Early-onset non-GBS preterm meningitis4.5%1.8%9.4%Colbourn 2007
Early-onset non-GBS term meningitis20.1%9.3%39.8%Colbourn 2007
Diagnostic tests
CRP > 10 mg/l at either presentation or 24 hours - sensitivity92.6%Calculated
CRP > 10 mg/l at either presentation or 24 hours - specificity80.9%Calculated
CRP > 10 mg/l at 24 hours - sensitivity92.9%87.5%98.4%Benitz 1998
CRP > 10 mg/l at 24 hours -specificity83.9%81.5%86.3%Benitz 1998
CRP > 10 mg/l At any of the next two mornings after presentation in the prediction of infection within the first 3 days of life - sensitivity97.6%95.8%98.8%Benitz 1998
CRP > 10 mg/l At any of the next two mornings after presentation in the prediction of infection within the first 3 days of life - specificity79.0%76.3%81.7%Benitz 1998
CRP > 10 mg/l At any three readings in the prediction of infection within the first 3 days of life - sensitivity97.8%96.2%98.9%Benitz 1998
CRP > 10 mg/l At any three readings in the prediction of infection within the first 3 days of life - specificity76.3%73.5%79.1%Benitz 1998
Mortality
Mortality - term early-onset GBS with meningitis11.1%3.9%28.1%Colbourn 2007; BPSU database 2005
Mortality - term early-onset GBS bacteraemia alone5.0%2.7%9.0%Colbourn 2007; BPSU database 2005
Mortality - term early-onset non-GBS15.2%5.2%34.4%Colbourn 2007; BPSU database 2005
Mortality - preterm early-onset GBS with meningitis23.1%8.2%50.3%Colbourn 2007; BPSU database 2005
Mortality - preterm early-onset GBS bacteraemia alone17.2%11.5%25.1%Colbourn 2007; BPSU database 2005
Mortality - preterm early-onset non-GBS15.1%6.8%29.3%Colbourn 2007; BPSU database 2005
Disability due to infection
No disability - bacteraemia74.6%64.1%83.8%Colbourn 2007
Mild disability - bacteraemia4.5%1.1%10.0%Colbourn 2007
Moderate disability - bacteraemia13.9%7.2%22.2%Colbourn 2007
Severe disability - bacteraemia7.0%2.3%13.8%Colbourn 2007
No disability - meningitis61.5%53.5%68.9%Colbourn 2007
Mild disability - meningitis19.6%14.0%26.7%Colbourn 2007
Moderate disability - meningitis12.8%8.4%19.2%Colbourn 2007
Severe disability - meningitis6.1%3.2%11.2%Colbourn 2007
Life expectancy
Life expectancy - no disability or mild disability78.578.478.5Colbourn 2007
Life expectancy - Moderate disability67.838.178.5Colbourn 2007
Life expectancy - Severe disability26.114.538.8Colbourn 2007

From: 13, Health economics

Cover of Antibiotics for Early-Onset Neonatal Infection
Antibiotics for Early-Onset Neonatal Infection: Antibiotics for the Prevention and Treatment of Early-Onset Neonatal Infection.
NICE Clinical Guidelines, No. 149.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Aug.
Copyright © 2012, National Collaborating Centre for Women’s and Children’s Health.

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