Table 8.2Evidence profile for intrathecal baclofen testing follow up; upper limb; tone assessment

Number of studiesNumber of participantsEffectQuality
Intrathecal baclofen testingPlaceboRelative

(95% CI)
Absolute

(95% CI)
Ashworth scores when receiving test treatment with baclofen 50 microgram dose (better indicated by lower values)
1 study (Gilmartin 2000)51a--b-bVery low
Ashworth scores 6 months after CITB pump implantation
1 study (Gilmartin 2000)42c--b-bVery low
Ashworth scores 12 months after CITB pump implantation
1 study (Gilmartin 2000)40d--b-bVery low
Ashworth scores 24 months after CITB pump implantation
1 study (Gilmartin 2000)33e--b-bVery low

CI confidence interval, CITB continuous pump-administered intrathecal baclofen

a

Pre-post treatment data. Ashworth scores are not reported for the placebo phase.

b

No statistical comparison was given across groups

c

When receiving CITB baclofen patients had a statistically significant reduction in the mean Ashworth scores as compared with baseline at 6 months after implantation (n=41): 1.80 (0.72); (1.0 to 3.8)

d

When receiving CITB baclofen patients had a statistically significant reduction in the mean Ashworth scores as compared with baseline at 12 months after implantation(n=40): 1.73 (0.66); (1.0 to 4.1)

e

When receiving CITB baclofen patients had a statistically significant reduction in the mean Ashworth scores as compared with baseline at 24 months after implantation (n=32): 1.72 (0.69); (1.0 to 3.1)

See the complete GRADE Table K.8.2 which accompanies this abbreviated version.

From: 8, Intrathecal baclofen

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Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
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