Table 7.5Evidence profile for botulinum toxin type A and physical therapy compared with physical therapy alone; upper limb; quality of life assessment

Number of studiesNumber of participantsEffectQuality
Botulinum toxin type A and occupational therapyOccupational therapy onlyRelative

(95% CI)
Absolute

(95% CI)
CHQ physical functioning domain score at 3 months (better indicated by higher values)
3 studies (Boyd 2004; Russo 2007; Wallen 2007)5654-MD 3.88 lower (15.48 lower to 7.72 higher)*Moderate
CHQ physical functioning domain score at 6 months (better indicated by higher values)
2 studies (Russo 2007; Wallen 2007)4139-MD 0.28 higher (12.2 lower to 12.75 higher)*Moderate
CHQ role emotional domain score at 3 months (better indicated by higher values)
3 studies (Boyd 2004; Russo 2007; Wallen 2007)5654-MD 12.98 higher (1.37 to 24.60 higher)*Moderate
CHQ role emotional domain score at 6 months (better indicated by higher values)
2 studies (Russo 2007; Wallen 2007)4139-MD 7.30 higher (7.75 lower to 22.34 higher)Moderate
CHQ physical functioning domain score at 3 months (better indicated by higher values)
3 studies (Boyd 2004; Russo 2007; Wallen 2007)5654-MD 8.79 higher (3.04 lower to 20.62 higher)Moderate
CHQ physical functioning domain score at 6 months (better indicated by higher values)
2 studies (Russo 2007; Wallen 2007)4139-MD 2.02 higher (13.98 lower to 18.02 higher)Moderate

CHQ Child Health Questionnaire, CI confidence interval, MD mean difference

*

Calculated by the NCC-WCH from data in Hoare 2010 Cochrane systematic review

See Table J.7.5 forest plot for the meta-analyses reported in this table.

See the complete GRADE Table K.7.5 which accompanies this abbreviated version.

From: 7, Botulinum toxin

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
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