Table K.8.14Evidence profile for continuous pump administered intrathecal baclofen follow up and compared with usual care; functioning assessment (ease of care)

Quality assessmentSummary of findings
No. of patientsEffectQuality
No. of studiesDesignLimitationsInconsistencyIndirectnessImprecisionOther considerationsContinuous pump-administered intrathecal baclofen therapy (CITB)Usual careRelative (95% CI)Absolute (95% CI)
Ease of care Mean Visual Analogue Scale (VAS) score at 6 months (better indicated by higher values)
1 study (Hoving 2009a)randomised trialno serious limitationsno serious inconsistencyno serious indirectnessserious1none9273-4-4Moderate
Ease of care Mean VAS score at 6 months after pump implantation (better indicated by higher values)
1 study (Hoving 2009b)observational studyserious5no serious inconsistencyno serious indirectnessserious1none166-7-7Very low
Mean VAS score at 12 months after pump implantation (better indicated by higher values)
1 study (Hoving 2009b)observational studyserious5no serious inconsistencyno serious indirectnessserious1none168--7-7Very low

CI confidence interval

1

Total population less than 400, 95% confidence interval not calculable

2

Mean 3.9 standard deviation (SD) (2.2) p value not reported compared to baseline

3

Mean 0.1 SD (1.6) p value not reported compared to baseline

4

p=0.008

5

Pre-post treatment data

6

Mean 4.4 SD (2.1) p<0.001 compared to baseline

7

No statistical comparison was given across groups

8

Mean 5.2 SD (2.1) p<0.001 compared to baseline

From: Appendix K, GRADE tables

Cover of Spasticity in Children and Young People with Non-Progressive Brain Disorders
Spasticity in Children and Young People with Non-Progressive Brain Disorders: Management of Spasticity and Co-Existing Motor Disorders and Their Early Musculoskeletal Complications.
NICE Clinical Guidelines, No. 145.
National Collaborating Centre for Women's and Children's Health (UK).
London: RCOG Press; 2012 Jul.
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