Figure 2 is the framework for organizing quantitative approaches. Figure 2 defines the steps of benefits and harms assessment. It includes, reporting of benefits and harms, quantitative approaches, decision making at the population level, and decision making at the individual level.

Figure 2Framework for organizing quantitative approaches

BLRA = benefit-less-risk analysis; Gail/NCI = Gail/National Cancer Institute approach: INHB = incremental net health benefit; MAR = maximum acceptable risk; MCE = minimum clinical efficacy; MCDA = multicriteria decision analysis; MERT = minimum target event risk for treatment; NCB = net clinical benefit; NNT = number needed to treat; NNH = number needed to harm; NNTt = threshold number needed to treat; PSM = probabilistic simulation methods; Q-TWiST = (quality-adjusted) time without symptoms and toxicity; QFRBA = quantitative framework for risk and benefit assessment; RBC = risk–benefit contour; RBP = risk–benefit plane; RV-NNT = relative value adjusted number needed to treat; TURBO = transparent uniform risk benefit overview; SPM = stated preference method;

From: Methodological Characteristics of Existing Quantitative Approaches for Assessing Benefit and Harm

Cover of Methods for Benefit and Harm Assessment in Systematic Reviews
Methods for Benefit and Harm Assessment in Systematic Reviews [Internet].
Boyd CM, Singh S, Varadhan R, et al.

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