TABLE 32Parameters varied in the sensitivity analysis

Type of parameter variedParameter applied to calculate
ProbabilitiesDeath when on and off transfusion for different age groups

First stroke for different age groups and transfusion regimens

Moving to a different health state post stroke

Remaining on transfusion to the age of 18 years

TCD scan of < 200 cm/second per cycle

SCD complications
CostsPost-stroke treatment for different severity of strokes (immediate and ongoing costs)

Chelation

Transfusion

Transfusion of alloimmunised patients
DisutilitiesAssociated with patients who have:
  • TCD scan of > 200 cm/second and not receiving blood transfusion
  • Injection chelation

From: 5, Assessment of cost-effectiveness

Cover of The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation
The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation.
Health Technology Assessment, No. 16.43.
Cherry MG, Greenhalgh J, Osipenko L, et al.
Southampton (UK): NIHR Journals Library; 2012 Nov.
© 2012, Crown Copyright.

Included under terms of UK Non-commercial Government License.

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