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Chou R, Cottrell EB, Wasson N, et al. Screening for Hepatitis C Virus Infection in Adults [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2012 Nov. (Comparative Effectiveness Reviews, No. 69.)

  • This publication is provided for historical reference only and the information may be out of date.

This publication is provided for historical reference only and the information may be out of date.

Cover of Screening for Hepatitis C Virus Infection in Adults

Screening for Hepatitis C Virus Infection in Adults [Internet].

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Appendix AExact Search Strategy

The following databases have been searched for relevant information and an updated search was conducted in May 2012:

Database Searches: Hepatitis C: Screening/Diagnosis, Treatment, and Pregnancy

NameDate LimitsPlatform Provider
Medline2002 to May Week 3 2012OvidSP
Embase2002–2012Embase (Elsevier)
Cochrane Library:
 CDSR, DARE, CCRCT
2002–2012Cochrane Library
Clinical Trials.gov2002–2012
Drugs@FDA2002–2012
Health Canada Drug Products Database2002–2012
European Public Assessment Reports (European Medicine Agency)2002–2012
Scopus2002–2012Scopus
PsycINFO2002 to May Week 4 2012OvidSP

Hand Search of Journals & Supplements - Topic-Specific Search Terms

ConceptControlled VocabularyKeywords
Hepatitis CHepatitis C/
Hepatitis C, Chronic/
Hepacivirus/OR
hcv.mp
hepacivirus$.mp
ScreeningExp Mass screening/
Population surveillance/
Sentinel Surveillance/
Seroepidemiologic Studies/
((public$ or communit$ or universal$ or widespread or open$ or unrestricted or group$ or adult$) adj3 (screen$ OR test$ or surveillance))
(antibod$ ADJ3 (test$ or screen$ or surveillance))
DiagnosisHepatitis C/di, pa, ra, us
Immunoenzyme Techniques/Enzyme-Linked Immunosorbent Assay/
Immunoblotting/
Polymerase Chain Reaction/
Reverse Transcriptase Polymerase Chain Reaction/
Liver function tests/
(liver/AND biopsy/)
Breath Tests/
Diagnostic Imaging/
Magnetic Resonance Imaging/
EXP Tomography, X-ray Computed/
Alanine Transaminase/
“sensitivity and specificity”/
Limit of Detection/
ROC Curve/
Diagnostic errors/
False Negative Reactions/
False Positive Reactions/
Hepatitis C Antibodies/
Antibodies, viral/
ELISA
EIA
recombinant immunoblot assay
RIBA
PCR
RT-PCR
transcription-mediated amplification
TMA
Branched-chain DNA
bDNA
radioimmunoblot assay
HCV-RNA
(liver$ ADJ3 biops$)
Fibrosis
non-invasive
blood test$
blood marker$
breath$ test$
transient elastography
Fibrometer
FibroTest
Hepascore
MRI
alanine aminotransferase
ALT
misdiagnos$
CT-scan
Ultrasound
HCV Antibodies
anti hcv
anti-hcv
TreatmentAntiviral agents/
Interferons/
Interferon-alpha/
Interferon Alfa-2a/
Interferon Alpha-2b/
Exp Polyethylene Glycols/
Ribavirin/
Exp Protease Inhibitors/
Interferon$
interferon alpha-2a
interferon alpha-2b
IFNalpha2a
IFNalpha2b
interferon alpha 2a
interferon alpha 2b
pegasys
Peg-intron
peginterferon alpha-2a peginterferon alpha-2b peginterferon alpha 2a peginterferon alpha 2b
pegylated interferon$
IFN$
PEG IFN$
Ribavirin
RBV
protease inhibitor$ polymerase inhibit$
HCV protease$
Telaprevir
boceprevir
Harms - treatmentAE.fs
MO.fs
PO.fs
TO.fs
CT.fs


AE=adverse effects
CT=contraindications
MO=mortality
PO=poisoning
TO=toxicity
Unsafe
Safety
harm$
complication$
poison$
risk$
side-effect$
side effect$
(undesirable ADJ1 effect$)
(treatment ADJ1 emergent) tolerab$
toxic$
adrs
(adverse ADJ2 (effect or effects or reaction or reactions or event or events or outcome or outcomes))
(undesirable ADJ1 effect$)
(treatment ADJ1 emergent) tolerab$
toxic$
adrs
(adverse ADJ2 (effect or effects or reaction or reactions or event or events or outcome or outcomes))
Harms - screeningAE.fs
CT.fs

AE=adverse effects
CT=contraindications
Unsafe
Safety
Harm
Harm
complication$
risk$
side-effect$
(undesirable ADJ1 effect$)
(treatment ADJ1 emergent)
tolerab$
adrs
(adverse ADJ2 (effect or effects or reaction or reactions or event or events or outcome or outcomes))
Anxiety
anxious$
label$
impact$
PregnancyPregnancy/
Pregnancy Complications, Infectious/
Pregnancy Complications/
Exp Delivery, Obstetric/
Maternal Exposure/
Fetus/
Infant, Newborn/
Infant/
Prenatal Diagnosis/
Neonatal Screening/
Prenatal Care/
Infectious Disease Transmission, Vertical/
Milk, Human/
Breast Feeding/
Postpartum Period/
gravid$
pregnan$
prenatal
perinatal
antenatal
parturiency
partuition
gestat$
childbirth
child birth
reproduct$
birth$
childbearing
child-bearing
High Risk GroupsSubstance-abuse, Intravenous/ Needle Sharing/
Opioid-Related Disorders/
Unsafe Sex/
Sexual Behavior/
HIV/
HIV Infections/
high risk
high-risk
drug$ abuse$
Counseling ImmunizationsCounseling/
Sex Counseling/
Health Education/
Patient Education as Topic/ Psychotherapy/
Behavior Therapy/
Cognitive Therapy/
Immunization/
Immunotherapy/
Psychotherapy, Brief/ Socioenvironmental Therapy/

Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1947 to June Week 2 2011,
Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations June 17, 2011

Date Searched: 06/20/2011

1Hepatitis C/ or Hepatitis C, Chronic/ or Hepacivirus/ or Hepatitis C.mp. or hepacivirus$.mp. or HCV.mp.54983
2Mass Screening/ or Population Surveillance/ or Sentinel Surveillance/ or Seroepidemiologic Studies/ or Prenatal Diagnosis/ or Neonatal Screening/ or Infectious Disease Transmission, Vertical/ or Disease Transmission, Infectious/ or tm.fs. or transmi$.ti,ab. or ((public$ or communit$ or universal$ or widespread or open$ or unrestricted or group$ or adult$ or adolescen$ or antibod$) adj3 (screen$ or test$ or surveillance)).ti,ab.555260
3Pregnancy/ or Pregnancy Complications, Infectious/ or Pregnancy Complications/ or exp Delivery, Obstetric/ or Maternal-Fetal Exchange/ or Fetal Monitoring/ or Labor, Induced/ or Fetus/ or Infant, Newborn/ or Infant/ or Prenatal Care/ or Milk, Human/ or Breast Feeding/ or Postpartum Period/ or exp cesarean section/ or exp obstetric labor/ or amniocentesis/ or chorionic villi/1401109
41 and 2 and 31247
5remove duplicates from 41234

Medline Update Search
Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1946 to October Week 3 2011,
Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations October 31, 2011

Date Searched: 05/31/2012

1Hepatitis C/ or Hepatitis C, Chronic/ or Hepacivirus/ or Hepatitis C.mp. or hepacivirus$.mp. or HCV.mp.58120
2Mass Screening/ or Population Surveillance/ or Sentinel Surveillance/ or Seroepidemiologic Studies/ or Prenatal Diagnosis/ or Neonatal Screening/ or Infectious Disease Transmission, Vertical/ or Disease Transmission, Infectious/ or tm.fs. or transmi$.ti,ab. or ((public$ or communit$ or universal$ or widespread or open$ or unrestricted or group$ or adult$ or adolescen$ or antibod$) adj3 (screen$ or test$ or surveillance)).ti,ab.576254
3Pregnancy/ or Pregnancy Complications, Infectious/ or Pregnancy Complications/ or exp Delivery, Obstetric/ or Maternal-Fetal Exchange/ or Fetal Monitoring/ or Labor, Induced/ or Fetus/ or Infant, Newborn/ or Infant/ or Prenatal Care/ or Milk, Human/ or Breast Feeding/ or Postpartum Period/ or exp cesarean section/ or exp obstetric labor/ or amniocentesis/ or chorionic villi/1436320
41 and 2 and 31291
5remove duplicates from 41250

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