Table 6Overview of CLABSI articles that control for confounding or secular trend

Author, location-yearStudy typeAnalysis for infection ratesSample size (infections)Organizational changeProvider educationAudit and feedbackProvider reminder systemsPatient educationFinancial incentives
Scales, Canada - 201158Cluster RCTGeneralized linear mixed model
Speroff, United States - 201160Cluster RCTHierarchical negative binomial regression
Lilly, United States - 201153Nonrandomized stepped wedgeLogistic regressionpre: 1529 (19)
post: 4761 (29)
Berenholtz, United States - 200449Controlled interrupted time seriesPoisson regression
Khouli, United States - 201161Controlled before-afterGeneralized linear model with Poisson distributioncontrol pre: (12)
control post: (8)
study pre: (20)
study post: (5)
Perez Parra, Spain - 201062Controlled before-afterPoisson regressioncontrol pre: (118)
control post: (91)
study pre: (45)
study post: (34)
Barsuk, United States - 200963Controlled before-afterPoisson regressioncontrol pre: (22)
control post: (17)
study pre: (25)
study post: (4)
Apisarnthanarak, Thailand - 201064Interrupted time seriesSegmented regressionpre: 1115 (88)
post: 1204 (7)
Costello, United States - 200845Interrupted time seriesSegmented regressionpre: 911 (26)
post: 936 (11)
Miller, United States - 201065/105Interrupted time seriesGeneralized linear model
McKee, United States - 200866Simple before-afterStatistical process control chart
Frankel, United States - 200576Simple before-afterStatistical process control chart
Wall, United States - 200577Simple before-afterStatistical process control chart
DePalo, United States - 201067Simple before-afterMixed model with Poisson distribution
Pronovost, United States - 201046Simple before-afterGeneralized linear latent and mixed model with Poisson distribution
Render, United States - 201171Simple before-afterPoisson GEE regression2006: (681)
2007: (683)
2008: (543)
2009: (404)
Zingg, Switzerland - 200968Simple before-afterCox proportional hazards modelpre: 499 (24)
post: 500 (7)
Barrera, Colombia - 201148Simple before-afterPoisson regressiontotal: 14,516 (total # HAI: 2,398)
Kim, United States - 201172Simple before-afterPoisson regressionpre: (275)
post: (50)
Harris, United States - 201174Simple before-afterLogistic regressionpre: 817 (31)
intervention: 601 (19)
post: 961 (15)
Seguin, France - 201069Simple before-afterPoisson regressionpre: 676 (12)
post: 595 (2)
Duane, United States - 200970Simple before-afterPoisson regressionpre: 135 (19)
post: 213 (13)
Yoo, Korea - 200178Simple before-afterLogistic regressionpre: 100
post: 148
Taylor, United States - 201173Simple before-afterCox regressionpre: 100 (23)
post: 100 (24)
Schulman, United States - 201159Simple before-afterStepwise Poisson regression
Burrell, Australia - 201175Simple before-afterLogistic regression

From: Results

Cover of Closing the Quality Gap: Revisiting the State of the Science (Vol. 6: Prevention of Healthcare-Associated Infections)
Closing the Quality Gap: Revisiting the State of the Science (Vol. 6: Prevention of Healthcare-Associated Infections).
Evidence Reports/Technology Assessments, No. 208.6.
Mauger Rothenberg B, Marbella A, Pines E, et al.

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