Table 55Summary of strength of evidence for the development of akathisia when anticholinergic agents are added to metoclopramide or phenothiazines

OutcomeComparison (# Studies)Strength of EvidenceSummary
AkathisiaMetoclopramide+anticholinergic vs. phenothiazine+ anticholinergic (1 RCT)InsufficientNo significant difference
(OR = 1.50; 95% CI: 0.24, 9.52)
AkathisiaProchlorperazine + DPH vs. prochlorperazine (1 RCT)InsufficientNo significant difference
(OR = 0.46; 95% CI: 0.17, 1.28)

DPH = diphenhydramine; OR = odds ratio; RCT = randomized controlled trial

From: Summary and Discussion

Cover of Acute Migraine Treatment in Emergency Settings
Acute Migraine Treatment in Emergency Settings [Internet].
Comparative Effectiveness Reviews, No. 84.
Sumamo Schellenberg E, Dryden DM, Pasichnyk D, et al.

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