Structured Abstract

Contents

• Preface
• Key Informants and Technical Expert Panel
• Peer Reviewers
• Executive Summary
• Introduction
  • Background
  • Objectives
  • Key Questions
  • Analytic Framework
• Methods
  • Input From Stakeholders
  • Searching for the Evidence
  • Inclusion and Exclusion Criteria
  • Data Extraction and Data Management
  • Assessment of Methodological Quality of Included Studies
  • Data Synthesis
  • Grading the Strength of the Evidence
  • Evaluating the Applicability of the Evidence
• Results
  • Organization of Results
  • Study Identification
  • Study Characteristics
  • Key Question 1
  • Key Question 2
  • Key Question 3
• Discussion
  • Applicability
  • Research Gaps and Future Research Needs
• References
• Acronyms/Abbreviations
• Appendix A Search Strategy
• Appendix B Data Extraction Form
• Appendix C Excluded Studies From Full-Text Review
• Appendix D Baseline Characteristics for Included Studies and Trials
• Appendix E Quality and Characteristics of Included Trials and Studies
• Appendix F Evidence Tables
• Appendix G Strength of Evidence for Outcomes
• Appendix H Applicability of Individual Studies
• Appendix I Glossary
• Appendix J Abbreviations

Prepared for: Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services¹, Contract No. 290-2007-10067-I, Prepared by: The University of Connecticut/Hartford Hospital Evidence-based Practice Center, Hartford, CT

Suggested citation:

Lee S, Coleman CI, Limone B, Kaur R, White CM, Kluger J, Sobieraj DM. Biologic and Nonbiologic Systemic Agents and Phototherapy for Treatment of Chronic Plaque Psoriasis. Comparative Effectiveness Review No. 85. (Prepared by the University of Connecticut/Hartford Hospital Evidence-based Practice Center under Contract No. 290-2007-10067-I.) AHRQ Publication No.12(13)-EHC144-EF. Rockville, MD: Agency for Healthcare Research and Quality. November 2012. www.effectivehealthcare.ahrq.gov/reports/final.cfm.

This report is based on research conducted by the University of Connecticut/Hartford Hospital Evidence-based Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No.290-2007-10067-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

The information in this report is intended to help health care decisionmakers—clinicians, health system leaders, and policymakers, among others—make well-informed decisions and thereby improve the quality of health care services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients.

This report may be used, in whole or in part, as the basis for development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.

None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report.

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