Figure 9. Summary of SAR Performed on the Probe (ML238; 54 Synthetic Analogs).

Figure 9Summary of SAR Performed on the Probe (ML238; 54 Synthetic Analogs)

Summary of SAR studies showing that the SRRS stereoisomer series as well as aromatic groups at the urea and sulfonamide positions are preferred for activity, while amines are preferred at C-12, particularly for aqueous solubility.

From: ML238: An Antimalarial Small Molecule of a Unique Structural Class

Cover of Probe Reports from the NIH Molecular Libraries Program
Probe Reports from the NIH Molecular Libraries Program [Internet].

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