Table 21Hypertension: strength of evidence for education and behavioral support (phone, mail, and/or video) interventions

InterventionNumber of Studies; Subjects (Analyzed)OutcomeRisk of BiasConsistencyDirectnessPrecisionMagnitude of Effect and Strength of Evidence
Hypertension education and behavioral support vs. usual care5; 6996 (5149 + NR in 2 trials)Medication adherence, overall (all measures)RCT
Medium
ConsistentDirectImpreciseMultiple variable outcomes
Two RCTs with stat sig difference in adherence:
  1. 6 percentage points more change in % pills taken in G1 than G2 from baseline to 6 months
  2. More in G1 than G2 reporting adherence at 12 and 18 months, no numbers reported
    Low
1; 299 (267)SBPRCT
Medium
UnknownDirectImpreciseNo stat sig difference between groups in change from baseline to 6 months
Insufficient
1; 299 (267)DBPRCT
Medium
UnknownDirectImpreciseNo stat sig difference between groups in change from baseline to 6 months
Insufficient

Abbreviations: DBP = diastolic blood pressure; G = group; NR = not reported; RCT = randomized controlled trial; SBP = systolic blood pressure; stat sig = statistically significant.

From: Results

Cover of Closing the Quality Gap: Revisiting the State of the Science (Vol. 4: Medication Adherence Interventions: Comparative Effectiveness)
Closing the Quality Gap: Revisiting the State of the Science (Vol. 4: Medication Adherence Interventions: Comparative Effectiveness).
Evidence Reports/Technology Assessments, No. 208.4.
Viswanathan M, Golin CE, Jones CD, et al.

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