TABLE 7-1Some Associations Between HLA Type and Specific Diseases

Antigen Frequency
DiseaseGroupHLA typePatientsControl SubjectsRelative riskaP valueNumber of Studiesb
Joint Disease
Ankylosing spondylitisWhiteB2789.88.087.81.0 × 10-1017
JapaneseB2766.70.0305.71.0 × 10-101
Haida IndiansB27100.05034.41.7 × 10-91
Bella Coola IndiansB27100.020.220.21.9 × 10-21
Pima IndiansB2736.018.02.61.0 × 10-31
Reiter's diseaseWhiteB2778.28.435.91.0 × 10-108
Yersinia arthritisWhiteB2779.49.424.31.0 × 10-102
Salmonella arthritisWhiteB2766.78.617.63.6 × 10-102
Psoriatic arthritisWhiteB1319.85.54.89.6 × 10-105
Central jointsB2740.28.78.61.0 × 10-45
Bw1711.65.52.54.6 × 10-35
Bw3822.72.99.15.6 × 10-65
Peripheral jointsWhiteB139.95.52.39.5 × 10-35
B2715.58.72.53.5 × 10-45
Bw1724.85.55.81.0 × 10-105
Bw3812.62.94.53.2 × 10-45
Juvenile rheumatoid arthritisWhiteB2726.48.54.71.0 × 10-107
Rheumatoid arthritisWhiteDw442.215.73.01.0 × 10-52
WhiteCw330.017.02.71.0 × 10-21
Disease of the Endocrine Glands
Thyroid disease
Graves' diseaseWhiteB836.721.72.131.0 × 10-66
Dw350.021.74.01.0 × 10-43
JapaneseBw3556.820.54.971.0 × 10-51
deQuervain's thyroiditisWhiteBw3576.912.522.21.0 × 10-102
Adrenal disease
Addison's diseaseWhiteB850.022.73.97.3 × 10-62
Dw370.021.710.51.0 × 10-31
Pancreatic disease
DiabetesWhiteB836.721.82.11.0 × 10-108
Juvenile onset diabetesBwl522.814.92.11.0 × 10-108
Gastrointestinal Tract Disease
Chronic active hepatitisWhiteA141.628.41.86.4 × 10-55
B844.220.33.01.0 × 10-105
Dw360.021.77.21.0 × 10-32
Celiac disease (gluten enteropathy)WhiteA163.729.54.21.0 × 10-107
B871.223.18.81.0 × 10-109
Dw398.015.02781.0 × 10-51
HemochromatosisWhiteA378.427.09.52.1 × 10-112
B1425.53.49.235.3 × 10-51
Ulcerative colitisJapaneseB580.030.89.31.0 × 10-31
Pernicious anemiaWhiteB735.822.12.21.2 × 10-43
Skin Disease
PsoriasisWhiteB1319.74.54.651.0 × 10-106
Bw1726.27.84.71.0 × 10-106
Bw377.71.45.41.0 × 10-103
Dermatitis herpetiformisWhiteA169.030.14.41.0 × 10-105
B877.024.79.21.0 × 10-106
Pemphigus vulgarisWhiteA1039.312.73.11.2 × 10-43
Herpes labialisWhiteA155.625.13.71.3 × 10-61
B833.316.82.53.5 × 10-41
Eye Disease
Anterior uveitisWhiteB2756.87.715.41.0 × 10-42
Vogt-Koyanagi-Harada diseaseJapaneseB22J42.913.24.52.0 × 10-21
Malignant Disease
Hodgkin's diseaseWhiteA131.1391.41.0 × 10-617
B510.6161.61.0 × 10-617
B823.7291.31.0 × 10-417
Bw187.1131.91.0 × 10-617
Acute lymphatic leukemiaWhiteA260.053.61.31.0 × 10-210
B829.023.71.31.0 × 10-210
Bw1829.025.21.31.0 × 10-210
Nasopharyngeal cancerChineseSia244.021.01.91.0 × 10-31
a

The relative risk is the ratio of the proportion of diseased individuals among carriers of a specific genetic trait to the proportion of diseased individuals among people who do not carry that trait.

b

The relative risk figures are derived from the combined data set.

SOURCE: Adapted from Vogel and Motulsky, 1979.

From: 7, Are Genetic Factors Involved in Racial and Ethnic Differences in Late-Life Health?

Cover of Racial and Ethnic Differences in the Health of Older Americans
Racial and Ethnic Differences in the Health of Older Americans.
National Research Council (US) Committee on Population; Martin LG, Soldo BJ, editors.
Washington (DC): National Academies Press (US); 1997.
Copyright © 1997, National Academy of Sciences.

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