Diagnostic criteria of Alzheimer’s disease according to ICD-10 (World Health Organisation, 1993)

  1. Presence of dementia
  2. Insidious onset and slowly progressive deterioration
    It is usually difficult to detect the onset of disorders and the patient’s entourage sometimes becomes suddenly aware of the presence of a deterioration
    An apparent plateau may occur in the progression
  3. Absence of argument, following the clinical examination and complementary investigations, to suggest that the mental state may be due to other systemic or brain disease which can induce a dementia (e.g. hypothyroidism, hypercalcemia, vitamin B12 deficiency, nicotinic acid deficiency, neurosyphilis, normal pressure hydrocephalus or subdural hematoma.)
  4. Non-sudden onset and absence, at an early stage of the evolution, of neurological signs of focal damage, e.g. hemiparesis, sensory loss, visual field defects or a lack of coordination (these manifestations may, however, be added secondarily)

From: Alzheimer’s Disease

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