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Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001.
Immunobiology: The Immune System in Health and Disease. 5th edition.
Show detailsAppendix II. CD antigens
| CD antigen | Cellular expression | Molecular weight (kDa) | Functions | Other names | Family relationships |
|---|---|---|---|---|---|
| CD1a,b,c,d | Cortical thymocytes, Langerhans' cells, dendritic cells, B cells (CD1c), intestinal epithelium, smooth muscle, blood vessels (CD1d) | 43–49 | MHC class I-like molecule, associated with β 2 -microglobulin. Has specialized role in presentation of lipid antigens | Immunoglobulin | |
| CD2 | T cells, thymocytes, NK cells | 45–58 | Adhesion molecule, binding CD58 (LFA-3). Binds Lck intracellularly and activates T cells | T11, LFA-2 | Immunoglobulin |
| CD3 | Thymocytes, T cells | γ:25–28, δ:20, ε:20 | Associated with the T-cell antigen receptor (TCR). Required for cellsurface expression of and signal transduction by the TCR | T3 | Immunoglobulin |
| CD4 | Thymocyte subsets, T H 1 and T H 2 T cells (about two thirds of peripheral T cells), monocytes, macrophages | 55 | Co-receptor for MHC class II molecules. Binds Lck on cytoplasmic face of membrane. Receptor for HIV-1 and HIV-2 gp120 | T4, L3T4 | Immunoglobulin |
| CD5 | Thymocytes, T cells, subset of B cells | 67 | T1, Ly1 | Scavenger receptor | |
| CD6 | Thymocytes, T cells, B cells in chronic lymphatic leukemia | 100–130 | Binds CD166 | T12 | Scavenger receptor |
| CD7 | Pluripotential hematopoietic cells, thymocytes, T cells | 40 | Unknown, cytoplasmic domain binds PI 3-kinase on cross-linking. Marker for T cell acute lymphatic leukemia and pluripotential stem cell leukemias | Immunoglobulin | |
| CD8 | Thymocytes subsets, cytotoxic T cells (about one third of peripheral T cells) | α: 32–34, β:32–34 | Co-receptor for MHC class I molecules. Binds Lck on cytoplasmic face of membrane | T8, Lyt2,3 | Immunoglobulin |
| CD9 | Pre-B cells, monocytes, eosinophils, basophils, platelets, activated T cells, brain and peripheral nerves, vascular smooth muscle | 24 | Mediates platelet aggregation and activation via FcγRIIa, may play a role in cell migration | Tetraspanning membrane protein, also called transmembrane 4 (TM4) | |
| CD10 | B- and T-cell precursors, bone marrow stromal cells | 100 | Zinc metalloproteinase, marker for pre-B acute lymphatic leukemia (ALL) | Neutral endopeptidase, common acute lymphocytic leukemia antigen (CALLA) | |
| CD11a | Lymphocytes, granulocytes, monocytes and macrophages | 180 | αL subunit of integrin LFA-1 (associated with CD18); binds to CD54 (ICAM-1), CD102 (ICAM-2), and CD50 (ICAM-3) | LFA-1 | Integrin α |
| CD11b | Myeloid and NK cells | 170 | αM subunit of integrin CR3 (associated with CD18): binds CD54, complement component iC3b, and extracellular matrix proteins | Mac-1 | Integrin α |
| CD11c | Myeloid cells | 150 | αX subunit of integrin CR4 (associated with CD18); binds fibrinogen | CR4, p150, 95 | Integrin α |
| CD11d | Leukocytes | 125 | αD subunits of integrin; associated with CD18; binds to CD50 | Integrin α | |
| CDw12 | Monocytes, granulocytes, platelets | 90–120 | Unknown | ||
| CD13 | Myelomonocytic cells | 150–170 | Zinc metalloproteinase | Aminopeptidase N | |
| CD14 | Myelomonocytic cells | 53–55 | Receptor for complex of lipopolysaccharide and lipopolysaccharide binding protein (LBP) | ||
| CD15 | Neutrophils, eosinophils, monocytes | Terminal trisaccharide expressed on glycolipids and many cell-surface glycoproteins | Lewisx (Lex) | ||
| CD15s | Leukocytes, endothelium | Ligand for CD62E, P | Sialyl-Lewisx (sLex) | poly-N-acetyllactosamine | |
| CD15u | Sulphated CD15 | Carbohydrate structures | |||
| CD16 | Neutrophils, NK cells, macrophages | 50–80 | Component of low affinity Fc receptor, FcγRIII, mediates phagocytosis and antibody-dependent cell-mediated cytotoxicity | FcγRIII | Immunoglobulin |
| CDw17 | Neutrophils, monocytes, platelets | Lactosyl ceramide, a cell-surface glycosphingolipid | |||
| CD18 | Leukocytes | 95 | Intergrin β2 subunit, associates with CD11a, b, c, and d | Integrin β | |
| CD19 | B cells | 95 | Forms complex with CD21 (CR2) and CD81 (TAPA-1); co-receptor for B cells—cytoplasmic domain binds cytoplasmic tyrosine kinases and PI 3-kinase | Immunoglobulin | |
| CD20 | B cells | 33–37 | Oligomers of CD20 may form a Ca 2+ channel; possible role in regulating B-cell activation | Contains 4 transmembrane segments | |
| CD21 | Mature B cells, follicular dendritic cells | 145 | Receptor for complement component C3d, Epstein-Barr virus. With CD19 and CD81, CD21 forms co-receptor for B cells | CR2 | Complement control protein (CCP) |
| CD22 | Mature B cells | α: 130, β:140 | Binds sialoconjugates | BL-CAM | Immunoglobulin |
| CD23 | Mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets | 45 | Low-affinity receptor for lgE, regulates lgE synthesis; ligand for CD19:CD21:CD81 co-receptor | FcεRII | C-type lectin |
| CD24 | B cells, granulocytes | 35–45 | Unknown | Possible human homologue of mouse heat stable antigen (HSA) | |
| CD25 | Activated T cells, B cells, and monocytes | 55 | IL-2 receptor α chain | Tac | CCP |
| CD26 | Activated B and T cells, macrophages | 110 | Exopeptidase, cleaves N terminal X-Pro or X-Ala dipeptides from polypeptides | Dipeptidyl peptidase IV | Type II transmembrane glycoprotein |
| CD27 | Medullary thymocytes, T cells, NK cells, some B cells | 55 | Binds CD70; can function as a co-stimulator for T and B cells | TNF receptor | |
| CD28 | T-cell subsets, activated B cells | 44 | Activation of naive T cells, receptor for co-stimulatory signal (signal 2) binds CD80 (B7.1) and CD86 (B7.2) | Tp44 | Immunoglobulin and CD86 (B7.2) |
| CD29 | Leukocytes | 130 | Integrin β1 subunit, associates with CD49a in VLA-1 integrin | Integrin β | |
| CD30 | Activated T, B, and NK cells, monocytes | 120 | Binds CD30L (CD153); cross-linking CD30 enhances proliferation of B and T cells | Ki-1 | TNF receptor |
| CD31 | Monocytes, platelets, granulocytes, T-cell subsets, endothelial cells | 130–140 | Adhesion molecule, mediating both leukocyte-endothelial and endothelial-endothelial interactions | PECAM-1 | Immunoglobulin |
| CD32 | Monocytes, granulocytes, B cells, eosinophils | 40 | Low affinity Fc receptor for aggregated immunoglobulin:immune complexes | FcγRIII | Immunoglobulin |
| CD33 | Myeloid progenitor cells, monocytes | 67 | Binds sialoconjugates | Immunoglobulin | |
| CD34 | Hematopoietic precursors, capillary endothelium | 105–120 | Ligand for CD62L (L-selectin) | Mucin | |
| CD35 | Erythrocytes, B cells, monocytes, neutrophils, eosinophils, follicular dendritic cells | 250 | Complement receptor 1, binds C3b and C4b, mediates phagocytosis | CR1 | CCP |
| CD36 | Platelets, monocytes, endothelial cells | 88 | Platelet adhesion molecule; involved in recognition and phagocytosis of apoptosed cells | Platelet GPIV, GPIIIb | |
| CD37 | Mature B cells, mature T cells, myeloid cells | 40–52 | Unknown, may be involved in signal transduction; forms complexes with CD53, CD81, CD82, and MHC class II | Transmembrane 4 | |
| CD38 | Early B and T cells, activated T cells, germinal center B cells, plasma cells | 45 | NAD glycohydrolase, augments B cell proliferation | T10 | |
| CD39 | Activated B cells, activated NK cells, macrophages, dendritic cells | 78 | Unknown, may mediate adhesion of B cells | ||
| CD40 | B cells, macrophages, dendritic cells, basal epithelial cells | 48 | Binds CD154 (CD40L); receptor for co-stimulatory signal for B cells, promotes growth, differentiation, and isotype switching of B cells, and cytokine production by macrophages and dendritic cells | TNF receptor | |
| CD41 | Platelets, megakaryocytes | Dimer: GPIIba:125, GPIIbb:22 | αIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor, and thrombospondin | GPIIb | Integrin α |
| CD42a,b,c,d | Platelets, megakaryocytes | a: 23; b: 135, 23; c: 22; d: 85 | Binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury | a: GPIX; b: GPIbα; c: GPIbβ; d: GPV | Leucine-rich repeat |
| CD43 | Leukocytes, except resting B cells | 115–135; 95–115 (T cells) (neutrophils) | Has extended structure, approx. 45 nm long and may be anti-adhesive | Leukosialin, sialophorin | Mucin |
| CD44 | Leukocytes, erythrocytes | 80–95 | Binds hyaluronic acid, mediates adhesion of leukocytes | Hermes antigen, Pgp-1 | Link protein |
| CD45 | All hematopoietic cells | 180–240 (multiple isoforms) | Tyrosine phosphatase, augments signaling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below) | Leukocyte common antigen (LCA), T200, B220 | Fibronectin type III |
| CD45RO | T-cell subsets, B-cell subsets, monocytes, macrophages | 180 | Isoform of CD45 containing none of the A, B, and C exons | Fibronectin type II | |
| CD45RA | B cells, T-cell subsets (naive T cells), monocytes | 205–220 | Isoforms of CD45 containing the A exon | Fibronectin type II | |
| CD45RB | T-cell subsets, B cells, monocytes, macrophages, granulocytes | 190–220 | Isoforms of CD45 containing the B exon | T200 | Fibronectin type II |
| CD46 | Hematopoietic and nonhematopoietic nucleated cells | 56/66 (splice variants) | Membrane co-factor protein, binds to C3b and C4b to permit their degradation by Factor I | MCP | CCP |
| CD47 | All cells | 47–52 | Adhesion molecule, thrombospondin receptor | IAP, MER6, OA3 | Immunoglobulin superfamily |
| CD48 | Leukocytes | 40–47 | Putative ligand for CD244 | Blast-1 | Immunoglobulin |
| CD49a | Activated T cells, monocytes, neuronal cells, smooth muscle | 200 | α1 integrin, associates with CD29, binds collagen, laminin-1 | VLA-1 | Integrin α |
| CD49b | B cells, monocytes, platelets, megakaryocytes, neuronal, epithelial and endothelial cells, osteoclasts | 160 | α2 integrin, associates with CD29, binds collagen, laminin | VLA-2, platelet GPIa | Integrin α |
| CD49c | B cells, many adherent cells | 125, 30 | α3 integrin, associates with CD29, binds laminin-5, fibronectin, collagen, entactin, invasin | VLA-3 | Integrin α |
| CD49d | Broad distribution includes B cells, thymocytes, monocytes, granulocytes, dendritic cells | 150 | α4 integrin, associates with CD29, binds fibronectin, MAdCAM-1, VCAM-1 | VLA-4 | Integrin α |
| CD49e | Broad distribution includes memory T cells, monocytes, platelets | 135, 25 | α5 integrin, associates with CD29, binds fibronectin, invasin | VLA-5 | Integrin α |
| CD49f | T lymphocytes, monocytes, platelets, megakaryocytes, trophoblasts | 125, 25 | α6 integrin, associates with CD29, binds laminin, invasin, merosine | VLA-6 | Integrin α |
| CD50 | Thymocytes, T cells, B cells, monocytes, granulocytes | 130 | Binds integrin CD11a/CD18 | ICAM-3 | Immunoglobulin |
| CD51 | Platelets, megakaryocytes | 125, 24 | αV integrin, associates with CD61, binds vitronectin, von Willebrand factor, fibrinogen, and thrombospondin; may be receptor for apoptotic cells | Vitronectin receptor | Integrin α |
| CD52 | Thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes, spermatozoa | 25 | Unknown, target for antibodies used therapeutically to deplete T cells from bone marrow | CAMPATH-1, HE5 | |
| CD53 | Leukocytes | 35–42 | Unknown | MRC OX44 | Transmembrane 4 |
| CD54 | Hematopoietic and nonhematopoietic cells | 75–115 | Intercellular adhesion molecule (ICAM)-1 binds CD11a/CD18 integrin (LFA-1) and CD11b/CD18 integrin (Mac-1), receptor for rhinovirus | ICAM-1 | Immunoglobulin |
| CD55 | Hematopoietic and nonhematopoietic cells | 60–70 | Decay accelerating factor (DAF), binds C3b, disassembles C3/C5 convertase | DAF | CCP |
| CD56 | NK cells | 135–220 | Isoform of neural cell-adhesion molecule (NCAM), adhesion molecule | NKH-1 | Immunoglobulin |
| CD57 | NK cells, subsets of T cells, B cells, and monocytes | Oligosaccharide, found on many cell-surface glycoproteins | HNK-1, Leu-7 | ||
| CD58 | Hematopoietic and nonhematopoietic cells | 55–70 | Leukocyte function-associated antigen-3 (LFA-3), binds CD2, adhesion molecule | LFA-3 | Immunoglobulin |
| CD59 | Hematopoietic and nonhematopoietic cells | 19 | Binds complement components C8 and C9, blocks assembly of membrane attack complex | Protectin, Mac inhibitor | Ly-6 |
| CD60a | Disialyl ganglioside D3 (GD3) | Carbohydrate structures | |||
| CD60b | 9- O -acetyl-GD3 | Carbohydrate structures | |||
| CD60c | 7- O -acetyl-GD3 | Carbohydrate structures | |||
| CD61 | Platelets, megakaryocytes, macrophages | 110 | Intergrin β3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin receptor) | Integrin β | |
| CD62E | Endothelium | 140 | Endothelium leukocyte adhesion molecule (ELAM), binds sialyl-Lewis x , mediates rolling interaction of neutrophils on endothelium | ELAM-1, E-selectin | C-type lectin, EGF, and CCP |
| CD62L | B cells, T cells, monocytes, NK cells | 150 | Leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling interactions with endothelium | LAM-1, L-selectin, LECAM-1 | C-type lectin, EGF, and CCP |
| CD62P | Platelets, megakaryocytes, endothelium | 140 | Adhesion molecule, binds CD162 (PSGL-1), mediates interaction of platelets with endothelial cells, monocytes and rolling leukocytes on endothelium | P-selectin, PADGEM | C-type lectin, EGF, and CCP |
| CD63 | Activated platelets, monocytes, macrophages | 53 | Unknown, is lysosomal membrane protein translocated to cell surface after activation | Platelet activation antigen | Transmembrane 4 |
| CD64 | Monocytes, macrophages | 72 | High-affinity receptor for lgG, binds IgG3>IgG1>IgG4>>>IgG2, mediates phagocytosis, antigen capture, ADCC | FcγRI | Immunoglobulin |
| CD65 | Myeloid cells | Oligosaccharide component of a ceramide dodecasaccharide | |||
| CD66a | Neutrophils | 160–180 | Unknown, member of carcino-embryonic antigen (CEA) family (see below) | Biliary glycoprotein-1 (BGP-1) | Immunoglobulin |
| CD66b | Granulocytes | 95–100 | Unknown, member of carcinoembryonic antigen (CEA) family | Previously CD67 | Immunoglobulin |
| CD66c | Neutrophils, colon carcinoma | 90 | Unknown, member of carcinoembryonic antigen (CEA) family | Nonspecific cross-reacting antigen (NCA) | Immunoglobulin |
| CD66d | Neutrophils | 30 | Unknown, member of carcinoembryonic antigen (CEA) family | Immunoglobulin | |
| CD66e | Adult colon epithelium, colon carcinoma | 180–200 | Unknown, member of carcinoembryonic antigen (CEA) family | Carcinoembryonic antigen (CEA) | Immunoglobulin |
| CD66f | Unknown | Unknown, member of carcinoembryonic antigen (CEA) family | Pregnancy specific glycoprotein | Immunoglobulin | |
| CD68 | Monocytes, macrophages, neutrophils, basophils, large lymphocytes | 110 | Unknown | Macrosialin | Mucin |
| CD69 | Activated T and B cells, activated macrophages and NK cells | 28, 32 homodimer | Unknown, early activation antigen | Activation inducer molecule (AIM) | C-type lectin |
| CD70 | Activated T and B cells, and macrophages | 75, 95, 170 | Ligand for CD27, may function in co-stimulation of B and T cells | Ki-24 | TNF |
| CD71 | All proliferating cells, hence activated leukocytes | 95 homodimer | Transferrin receptor | T9 | |
| CD72 | B cells (not plasma cells) | 42 homodimer | Unknown | Lyb-2 | C-type lectin |
| CD73 | B-cell subsets, T-cell subsets | 69 | Ecto-5′-nucleotidase, dephosphorylates nucleotides to allow nucleoside uptake | ||
| CD74 | B cells, macrophages, monocytes, MHC class II positive cells | 33, 35, 41, 43 (alternative initiation and splicing) | MHC class II-associated invariant chain | Ii, Iγ | |
| CD75 | Mature B cells, T-cells subsets | Lactosamines, ligand for CD22, mediates B-cell-B-cell adhesion | |||
| CD75s | α-2,6-sialylated lactosamines | Carbohydrate structures | |||
| CD77 | Germinal center B cells | Neutral glycosphingolipid (Galα1→4Galβ1→4Galcβ1 →ceramide), binds Shiga toxin, cross-linking induces apoptosis | Globotriaocyl-ceramide (Gb3) Pk blood group | ||
| CD79α,β | B cells | α: 40–45, β:37 | Components of B-cell antigen receptor analogous to CD3, required for cell-surface expression and signal transduction | Igα, Igβ | Immunoglobulin |
| CD80 | B-cell subset | 60 | Co-stimulator, ligand for CD28 and CTLA-4 | B7 (now B7.1), BB1 | Immunoglobulin |
| CD81 | Lymphocytes | 26 | Associates with CD19, CD21 to form B cell co-receptor | Target of antiproliferative antibody (TAPA-1) | Transmembrane 4 |
| CD82 | Leukocytes | 50–53 | Unknown | R2 | Transmembrane 4 |
| CD83 | Dendritic cells, B cells, Langerhans' cells | 43 | Unknown | HB15 | Immunoglobulin |
| CDw84 | Monocytes, platelets, circulating B cells | 73 | Unknown | GR6 | Immunoglobulin |
| CD85 | Dendritic cells | ILT/LIR family | GR4 | Immunoglobulin superfamily | |
| CD86 | Monocytes, activated B cells, dendritic cells | 80 | Ligand for CD28 and CTLA4 | B7.2 | Immunoglobulin |
| CD87 | Granulocytes, monocytes, macrophages, T cells, NK cells, wide variety of nonhematopoietic cell types | 35–59 | Receptor for urokinase plasminogen activator | uPAR | Ly-6 |
| CD88 | Polymorphonuclear leukocytes, macrophages, mast cells | 43 | Receptor for complement component C5a | C5aR | G protein-coupled receptor |
| CD89 | Monocytes, macrophages, granulocytes, neutrophils, B-cell subsets, T-cell subsets | 50–70 | IgA receptor | FcαR | Immunoglobulin |
| CD90 | CD34 + prothymocytes (human), thymocytes, T cells (mouse) | 18 | Unknown | Thy-1 | Immunoglobulin |
| CD91 | Monocytes, many nonhematopoietic cells | 515, 85 | α2-macroglobulin receptor | EGF, LDL receptor | |
| CD92 | Neutrophils, monocytes,platelets,endothelium | 70 | Unknown | GR9 | |
| CD93 | Neutrophils, monocytes,endothelium | 120 | Unknown | GR11 | |
| CD94 | T-cell subsets, NK cells | 43 | Unknown | KP43 | C-type lectin |
| CD95 | Wide variety of cell lines, in vivo distribution uncertain | 45 | Binds TNF-like Fas ligand,induces apoptosis | Apo-1, Fas | TNF receptor |
| CD96 | Activated T cells, NK cells | 160 | Unknown | T-cell activation increased late expression (TACTILE) | Immunoglobulin |
| CD97 | Activated B and T cells, monocytes, granulocytes | 75–85 | Binds CD55 | GR1 | EGF, G proteincoupled receptor |
| CD98 | T cells, B cells, natural killer cells, granulocytes, all human cell lines | 80, 45 heterodimer | May be amino acid transporter | 4F2, FRP-1 | |
| CD99 | Peripheral blood lymphocytes, thymocytes | 32 | Unknown | MIC2, E2 | |
| CD100 | Hematopoietic cells | 150 homodimer | Unknown | GR3 | Semaphorin |
| CD101 | Monocytes, granulocytes, dendritic cells, activated T cells | 120 homodimer | Unknown | BPC#4 | Immunoglobulin |
| CD102 | Resting lymphocytes, monocytes, vascular endothelium cells (strongest) | 55–65 | Binds CD11a/CD18 (LFA-1) but not CD11b/CD18(Mac-1) | ICAM-2 | Immunoglobulin |
| CD103 | Intraepithelial lymphocytes, 2–6% peripheral blood lymphocytes | 150, 25 | αE integrin | HML-1, α6,αE, integrin | Integrin α |
| CD104 | CD4 - CD8 - thymocytes, neuronal, epithelial, and some endothelial cells, Schwann cells, trophoblasts | 220 | Integrin β4 associates with CD49f, binds laminins | β4 integrin | Integrin β |
| CD105 | Endothelial cells, activated monocytes and macrophages, bone marrow cell subsets | 90 homodimer | Binds TGF-β | Endoglin | |
| CD106 | Endothelial cells | 100–110 | Adhesion molecule, ligand for VLA-4 (α 4 β 1 integrin) | VCAM-1 | Immunoglobulin |
| CD107a | Activated platelets, activated T cells, activated neutrophils, activated endothelium | 110 | Unknown, is lysosomal membrane protein translocated to the cell surface after activation | Lysosomal associated membrane protein-1 (LAMP-1) | |
| CD107b | Activated platelets, activated T cells, activated neutrophils, activated endothelium | 120 | Unknown, is lysosomal membrane protein translocated to the cell surface after activation | LAMP-2 | |
| CD108 | Erythrocytes, circulating lymphocytes, lymphoblasts | 80 | Unknown | GR2, John Milton-Hagen blood group antigen | |
| CD109 | Activated T cells, activated platelets, vascular endothelium | 170 | Unknown | Platelet activation factor, GR56 | |
| CD110 | Platelets | MPL, TPO R | |||
| CD111 | Myeloid cells | PPR1/Nectin1 | |||
| CD112 | Myeloid cells | PRR2 | |||
| CD114 | Granulocytes, monocytes | 150 | Granulocytes colony-stimulating factor (G-CSF) receptor | Immunoglobulin,fibronectin type III | |
| CD115 | Monocytes, macrophages | 150 | Macrophage colony-stimulating factor (M-CSF) receptor | M-CSFR, c-fms | Immunoglobulin, tyrosine kinase |
| CD116 | Monocytes, neutrophils, eosinophils, endothelium | 70–85 | Granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor α chain | GM-CSFRα | Cytokine receptor, fibronectin type III |
| CD117 | Hematopoietic progenitors | 145 | Stem-cell factor (SCF) receptor | c-kit | Immunoglobulin, tyrosine kinase |
| CD118 | Broad cellular expression | Interferon-α, β receptor | IFN-α, βR | ||
| CD119 | Macrophages, monocytes, B cells, endothelium | 90–100 | Interferon-γ receptor | IFN-γR | Fibronectin type III |
| CD120a | Hematopoietic and nonhematopoietic cells, highest on epithelial cells | 50–60 | TNF receptor, binds both TNF-α and TNF-β | TNFR-I | TNF receptor |
| CD120b | Hematopoietic and nonhematopoietic cells, highest on myeloid cells | 75–85 | TNF receptor, binds both TNF-α and TNF-β | TNFR-II | TNF receptor |
| CD121a | Thymocytes, T cells | 80 | Type I interleukin-1 receptor, binds IL-1α and IL-β | IL-1R type I | Immunoglobulin |
| CDw121b | B cells, macrophages, monocytes | 60–70 | Type II interleukin-1 receptor, binds IL-1α and IL-1β | IL-1R type II | Immunoglobulin |
| CD122 | NK cells, resting T-cell subsets, some B-cell lines | 75 | IL-2 receptor β chain | IL-2Rβ | Cytokine receptor, Fibronectin type III |
| CD123 | Bone marrow stem cells, granulocytes, monocytes, megakaryocytes | 70 | IL-3 receptor α chain | IL-3Rα | Cytokine receptor, Fibronectin type III |
| CD124 | Mature B and T cells, hematopoietic precursor cells | 130–150 | IL-4 receptor | IL-4R | Cytokine receptor, Fibronectin type III |
| CD125 | Eosinophils, basophils, activated B cells | 55–60 | IL-5 receptor | IL-5R | Cytokine receptor, Fibronectin type III |
| CD126 | Activated B cells and plasma cells (strong), most leukocytes (weak) | 80 | IL-6 receptor α subunit | IL-6Rα | Immunoglobulin, Cytokine receptor, Fibronectin type III |
| CD127 | Bone marrow lymphoid precursors, pro-B cells, mature T cells, monocytes | 68–79, possibly forms homodimers | IL-7 receptor | IL-7R | Fibronectin type III |
| CDw128 | Neutrophils, basophils, T-cell subsets | 58–67 | IL-8 receptor | IL-8R | G protein-coupled receptor |
| CD129 | Not yet assigned | ||||
| CD130 | Most cell types, strong on activated B cells and plasma cells | 130 | Common subunit of IL-6, IL-11, oncostain-M (OSM) and leukemia inhibitory factor (LIF) receptors | IL-6Rβ, IL-11Rβ,OSMRβ, LIFRβ, IFRβ | Immunoglobulin, Cytokine receptor, Fibronectin type III |
| CDw131 | Myeloid progenitors, granulocytes | 140 | Common β subunit of IL-3, IL-5, and GM-CSF receptors | IL-3Rβ, IL-5Rβ,GM-CSFRβ | Cytokine receptor, Fibronectin type III |
| CD132 | B cells, T cells, NK cells, mast cells, neutrophils | 64 | IL-2 receptor γ chain, common subunit of IL-2, IL-4, IL-7, IL-9 and IL-15 receptors | Cytokine receptor | |
| CD133 | Stem/progenitor cells | AC133 | |||
| CD134 | Activated T cells | 50 | May acts as adhesion molecule costimulator | OX40 | TNF receptor |
| CD135 | Multipotential precursors, myelomonocytic and B-cell progenitors | 130, 155 | Growth factor receptor | FLK2, STK-1 | Immunoglobulin, Tyrosine kinase |
| CDw136 | Monocytes, epithelial cells, central and peripheral nervous system | 180 | Chemotaxis, phagocytosis, cell growth, and differentiation | MSP-R, RON | Tyrosine kinase |
| CDw137 | T and B lymphocytes, monocytes, some epithelial cells | Co-stimulator of T-cell proliferation | ILA (induced by lymphocyte activation), 4–1BB | TNF receptor | |
| CD138 | B cells | Heparan sulphate proteoglycan binds collagen type I | Syndecan-1 | ||
| CD139 | B cells | 209, 228 | Unknown | ||
| CD140a,b | Stromal cells, some endothelial cells | a: 180, b: 180 | Platelet derived growth factor (PDGF) receptor α and β chains | ||
| CD141 | Vascular endothelial cells | 105 | Anticoagulant, binds thrombin, the complex then activates protein C | Thrombomodulin fetomodulin | C-type lectin, EGF |
| CD142 | Epidermal keratinocytes, various epithelial cells, astrocytes, Schwann cells. Absent from cells in direct contact with plasma unless induced by inflammatory mediators | 45–47 | Major initiating factor of clotting. Binds Factor VIIa; this complex activates Factors VII, IX, and X | Tissue factor, thromboplastin | Fibronectin type III |
| CD143 | Endothelial cells, except large blood vessels and kidney, epithelial cells of brush borders of kidney and small intestine, neuronal cells, activated macrophages and some T cells. Soluble form in plasma | 170–180 | Zn 2+ metallopeptidase dipeptidyl peptidase, cleaves angiotensin I and bradykinin from precursor forms | Angiotensin converting enzyme (ACE) | |
| CD144 | Endothelial cells | 130 | Organizes adherens junction in endothelial cells | Cadherin-5, VE-cadherin | Cadherin |
| CD145 | Endothelial cells, some stromal cells | 25, 90, 110 | Unknown | ||
| CD146 | Endothelium | 130 | Potential adhesion molecule, localized at cell-cell junctions | MCAM, MUC18, S-ENDO | Immunoglobulin |
| CD147 | Leukocytes, red blood cells, platelets, endothelial cells | 55–65 | Potential adhesion molecule | M6, neurothelin, EMMPRIN, basigin, OX-47 | Immunoglobulin |
| CD148 | Granulocytes, monocytes, dendritic cells, T cells, fibroblasts, nerve cells | 240–260 | Contact inhibition of cell growth | HPTPη | Fibronectin type III, protein tyrosine phosphatase |
| CD150 | Thymocytes, activated lymphocytes | 75–95 | Unknown | SLAM | Immunoglobulin |
| CD151 | Platelets, megakaryocytes, epithelial cells, endothelial cells | 32 | Associates with β1 integrins | PETA-3, SFA-1 | Transmembrane 4 |
| CD152 | Activated T cells | 33 | Receptor for B7.1 (CD80), B7.2 (CD86); negative regulator of T-cell activation | CTLA-4 | Immunoglobulin |
| CD153 | Activated T cells, activated macrophages, neutrophils, B cells | 38–40 | Ligand for CD30, may co-stimulate T cells | CD30L | TNF |
| CD154 | Activated CD4 T cells | 30 trimer | Ligand for CD40, inducer of B cell proliferation and activation | CD40L, TRAP, T-BAM, gp39 | TNF receptor |
| CD155 | Monocytes, macrophages, thymocytes, CNS neurons | 80–90 | Normal function unknown; receptor for poliovirus | Poliovirus receptor | Immunoglobulin |
| CD156a | Neutrophils, monocytes | 69 | Unknown, may be involved in integrin leukocyte extravasation | MS2, ADAM 8 (A disintegrin and metallo-protease) | |
| CD156b | TACE/ADAM17. Adhesion structures | ||||
| CD157 | Granulocytes, monocytes, bone marrow stromal cells, vascular endothelial cells, follicular dendritic cells | 42–45 (50 on monocytes) | ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase | BST-1 | |
| CD158 | NK cells | KIR family | |||
| CD158a | NK-cell subsets | 50 or 58 | Inhibits NK cell cytotoxicity on binding MHC class I molecules | p50.1, p58.1 | Immunoglobulin |
| CD158b | NK-cell subsets | 50 or 58 | Inhibits NK cell cytotoxicity on binding HLA-Cw3 and related alleles | p50.2, p58.2 | Immunoglobulin |
| CD159a | NK cells | Binds CD94 to form NK receptor; inhibits NK cell cytotoxicity on binding MHC class I moolecules | NKG2A | ||
| CD160 | T cells | BY55 | |||
| CD161 | NK cells, T cells | 44 | Regulates NK cytotoxicity | NKRP1 | C-type lectin |
| CD162 | Neutrophils, lymphocytes, monocytes | 120 homodimer | Ligand for CD62P | PSGL-1 | Mucin |
| CD162R | NK cells | PEN5 | |||
| CD163 | Monocytes, macrophages | 130 | Unknown | M130 | |
| CD164 | Epithelial cells, monocytes, bone marrow stromal cells | 80 | Unknown | MUC-24 (multi-glycosylated protein 24) | Mucin |
| CD165 | Thymocytes, thymic epithelial cells, CNS neurons, pancreatic islets, Bowman's capsule | 37 | Adhesion between thymocytes and thymic epithelium | Gp37, AD2 | |
| CD166 | Activated T cells, thymic epithelium, fibroblasts, neurons | 100–105 | Ligand for CD6, involved integrin neurite extension | ALCAM, BEN, DM-GRASP, SC-1 | Immunoglobulin |
| CD167a | Normal and transformed epithelial cells | 63, 64 dimer | Binds collagen | DDR1, trkE, cak, eddr1 | Receptor tyrosine kinase, discoidin-related |
| CD168 | Breast cancer cells | Five isoforms: 58, 60, 64, 70, 84 | Adhesion molecule. Receptor for hyaluronic acid-mediated motility—mediated cell migration | RHAMM | |
| CD169 | Subsets of macrophages | 185 | Adhesion molecule. Binds sialylated carbohydrates. May mediate macrophage binding to granulocytes and lymphocytes | Sialoadhesin | Immunoglobulin superfamily, sialoadhesin family |
| CD170 | Neutrophils | 67 homodimer | Adhesion molecule. S ialic acid-binding I g-like lec tin (Siglec). Cytoplasmic tail contains ITIM motifs | Siglec-5, OBBP2, CD33L2 | Immunoglobulin superfamily, sialoadhesin family |
| CD171 | Neurons, Schwann cells, lymphoid and myelomonocytic cells, B cells, CD4 T cells (not CD8 T cells) | 200–220, exact MW varies with cell type | Adhesion molecule, binds CD9, CD24, CD56, also homophilic binding | L1, NCAM-L1 | Immunoglobulin superfamily |
| CD172a | 115–120 | Adhesion molecule; the transmembrane protein is a substrate of activated receptor tyrosine kinases (RTKs) and binds to SH2 domains | SIRP, SHPS1, MYD-1, SIRP-α-1, protein tyrosine phosphatase, nonreceptor type substrate 1 (PTPNS1) | Immunoglobulin superfamily | |
| CD173 | All cells | Blood group H type 2. Carbohydrate moiety | |||
| CD174 | All cells | Lewis y Blood group. Carbohydrate moiety | |||
| CD175 | All cells | Tn Blood group. Carbohydrate moiety | |||
| CD175s | All cells | Sialyl-Tn Blood group. Carbohydrate moiety | |||
| CD176 | All cells | TF Blood group. Carbohydrate moiety | |||
| CD177 | Myeloid cells | 56-64 | NB1 is a GPI-linked neutrophil-specific antigen, found on only a subpopulation of neutrophils present in NB1-positive adults (97% of healthy donors) NB1 is first expressed at the myelocyte stage of myeloid differentiation | NB1 | |
| CD178 | Activated T cells | 38-42 | Fas ligand; binds to Fas to induce apoptosis | FasL | TNF superfamily |
| CD179a | Early B cells | 16–18 | Immunoglobulin iota chain associates noncovalently with CD179b to form a surrogate light chain which is a component of the pre-B-cell receptor that plays a critical role in early B-cell differentiation | VpreB, IGVPB, IGτ | Immunoglobulin superfamily |
| CD179b | B cells | 22 | Immunoglobulin λ-like polypeptide 1 associates noncovalently with CD179a to form a surrogate light chain that is selectively expressed at the early stages of B-cell development. Mutations in the CD179b gene have been shown to result in impairment of B-cell development and agammaglobulinemia in humans | IGLL1, λ5 (IGL5), IGVPB, 14. | Immunoglobulin superfamily |
| CD180 | B cells | 95-105 | Type 1 membrane protein consisting of extracellular leucine-rich repeats (LRR). Is associated with a molecule called MD-1 and forms the cell-surface receptor complex, RP105/MD-1, which by working in concert with TLR4, controls B-cell recognition and signaling of lipopolysaccharide (LPS) | LY64, RP105 | Toll-like receptors (TLR) |
| CD183 | Particularly on malignant B cells from chronic lymphoproliferative disorders | 46-52 | CXC chemokine receptor involved in chemotaxis of malignant B lymphocytes. Binds INP10 and MIG3 | CXCR3, G protein-coupled receptor 9 (GPR 9) | Chemokine receptors, G protein-coupled receptor superfamily |
| CD184 | Preferentially expressed on the more immature CD34+ haematopoietic stem cells | 46-52 | Binding to SDF-1 (LESTR/fusin); acts as a cofactor for fusion and entry of T-cell line; trophic strains of HIV-1 | CXCR4, NPY3R, LESTR, fusin, HM89 | Chemokine receptors, G protein-coupled receptor superfamily |
| CD195 | Promyelocytic cells | 40 | Receptor for a CC type chemokine. Binds to MIP-1α, MIP-1β and RANTES. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as co-receptor with CD4 for primary macrophage-tropic isolates of HIV-1 | CMKBR5, CCR5, CKR-5, CC-CKR-5, CKR5 | Chemokine receptors, G protein-coupled receptor superfamily |
| CDw197 | Activated B and T lymphocytes, strongly upregulated in B cells infected with EBV and T cells infected with HHV6 or 7 | 46-52 | Receptor for the MIP-3β chemokine; probable mediator of EBV effects on B lymphocytes or of normal lymphocyte functions | CCR7. EBI1 (Epstein-Barr virus induced gene 1), CMKBR7, BLR2 | Chemokine receptors, G protein-coupled receptor superfamily |
| CD200 | Normal brain and B-cell lines | 41 (rat thymocytes) 47 (rat brain) | Antigen identified by MoAb MRC OX-2. Nonlineage molecules. Function unknown | MOX-2, MOX-1 | Immunoglobulin superfamily |
| CD201 | Endothelial cells | 49 | Endothelial cell-surface receptor (EPCR) that is capable of high-affinity binding of protein C and activated protein C. It is downregulated by exposure of endothelium to tumor necrosis factor | EPCR | CD1major histocompatibility complex family |
| CD202b | Endothelial cells | 140 | Receptor tyrosine kinase, binds angiopoietin-1; important in angiogenesis, particularly for vascular network formation in endothelial cells. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis | VMCM, TEK (tyrosine kinase, endothelial), TIE2 (tyrosine kinase with Ig and EGF homology domains), VMCM1 | Immunoglobulin superfamily, tyrosine kinase |
| CD203c | Myeloid cells (uterus, basophils, and mast cells) | 101 | Belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. They catalyze the cleavage of phosphodiester and phosphosulfate bonds of a variety of molecules, including deoxynucleotides, NAD, and nucleotide sugars | NPP3, B10, PDNP3, PD-Iβ, gp130RB13-6 | Type II transmembrane proteins, Ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP) family |
| CD204 | Myeloid cells | 220 | Mediate the binding, internalization, and processing of a wide range of negatively charged macromolecules. Implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis | Macrophage scavenger R (MSR1) | Scavenger receptor family, collagen-like |
| CD205 | Dendritic cells | 205 | Lymphocyte antigen 75; putative antigen-uptake receptor on dendritic cells | LY75, DEC-205, GP200-MR6 | Type I transmembrane protein |
| CD206 | Macrophages, endothelial cells | 175-190 | Type I membrane glycoprotein; only known example of a C-type lectin that contains multiple C-type CRDs (carbohydrate-recognition domains); it binds high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi | Macrophage mannose receptor (MMR), MRC1 | C-type lectin superfamily |
| CD207 | Langerhans' cells | 40 | Type II transmembrane protein; Langerhans' cell specific C-type lectin; potent inducer of membrane superimposition and zippering leading to BG (Birbeck granules) formation | Langerin | C-type lectin superfamily |
| CD208 | Interdigitating dendritic cells in lymphoid organs | 70-90 | Homologous to CD68, DC-LAMP is a lysosomal protein involved in remodeling of specialized antigen-processing compartments and in MHC class II-restricted antigen presentation. Upregulated in mature DCs induced by CD40L, TNF-α and LPS. | D lysosome-associated membrane protein, DC-LAMP | Major histocompatibility complex family |
| CD209 | Dendritic cells | 44 | C-type lectin; binds ICAM3 and HIV-1 envelope glycoprotein gp120 enables T-cell receptor engagement by stabilization of the DC/T-cell contact zone, promotes efficient infection in trans cells that express CD4 and chemokine receptors; type II transmembrane protein | DC-SIGN (dendritic cellspecific ICAM3-grabbing nonintegrin) | C-type lectin superfamily |
| CDw210 | B cells, T helper cells, and cells of the monocyte/macrophage lineage | 90-110 | Interleukin 10 receptor α and β | IL-10Rα, IL-10RA, HIL-10R, IL-10Rβ, IL-10RB, CRF2-4, CRFB4 | Class II cytokine receptor family |
| CD212 | Activated CD4, CD8, and NK cells | 130 | IL-12 receptor β chain; a type I transmembrane protein involved in IL-12 signal transduction. | IL-12R IL-12RB | Haemopoietin cytokine receptor superfamily |
| CD213a1 | B cells, monocytes, fibroblasts, endothelial cells | 60-70 | Receptor which binds II-13 with a low affinity; together with IL-4Rα can form a functional receptor for IL-13, also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL-4 signaling | IL-13Rα 1, NR4, IL-13Ra | Haemopoietic cytokine receptor superfamily |
| CD213a2 | B cells, monocytes, fibroblasts, endothelial cells | IL-13 receptor which binds as a monomer with high affinity to interleukin-13 (IL-13), but not to IL-4; human cells expressing IL-13RA2 show specific IL-13 binding with high affinity | IL-13Rα 2, IL-13BP | Haemopoietic cytokine receptor superfamily | |
| CDw217 | Activated memory T cells | 120 | Interleukin 17 receptor homodimer | IL-17R, CTLA-8 | Chemokine/ cytokine receptors |
| CD220 | Nonlineage molecules | α: 130, β:95 | Insulin receptor; integral transmembrane glycoprotein comprised of two α and two β subunits; this receptor binds insulin and has a tyrosine-protein kinase activity—autophosphorylation activates the kinase activity | Insulin receptor | Insulin receptor family of tyrosine-protein kinases, EGFR family |
| CD221 | Nonlineage molecules | α: 135, β:90 | Insulin-like growth factor I receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity and plays a critical role in transformation events. Cleavage of the precursor generates α and β subunits. | IGF1R, JTK13 | Insulin receptor family of tyrosine-protein kinases, EGFR family |
| CD222 | Nonlineage molecules | 250 | Ubiquitously expressed multifunctional type I transmembrane protein. Its main functions include internalization of IGF-II, internalization or sorting of lysosomal enzymes and other M6P-containing proteins | IGF2R, CIMPR, CI-MPR, IGF2R, M6P-R (Mannose-6-phosphate receptor) | Mammalian lectins |
| CD223 | Activated T and NK cells | 70 | Involved in lymphocyte activation; binds to HLA class-II antigens; role in downregulating antigen specific response; close relationship of LAG3 to CD4 | Lymphocyteactivation gene 3 LAG-3 | Immunoglobulin superfamily |
| CD224 | Nonlineage molecules | 62 (unprocessed precursor) | Predominantly a membrane-bound enzyme; plays a key role in the γ-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide | γ-glutamyl transferase, GGT1, D22S672 D22S732 | γ-glutamyl transferase protein family |
| CD225 | Leukocytes and endothelial cells | 16–17 | Interferon-induced transmembrane protein 1 is implicated in the control of cell growth. It is a component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals | Leu 13, IFITM1, IFI17 | IFN-induced transmembrane proteins |
| CD226 | NK cells, platelets, monocytes, and a subset of T cells | 65 | Adhesion glycoprotein; mediates cellular adhesion to other cells bearing an unidentified ligand and cross-linking CD226 with antibodies causes cellular activation | DNAM-1 (PTA1), DNAX, TLiSA1 | Immunoglobulin superfamily |
| CD227 | Human epithelial tumors, such as breast cancer | 122 (nonglycosylated) | Epithelial mucin containing a variable number of repeats with a length of twenty amino acids, resulting in many different alleles. Direct or indirect interaction with actin cytoskeleton. | PUM (peanut-reactive urinary mucin), MUC.1, mucin 1 | Mucin |
| CD228 | Predominantly in human melanomas | 97 | Tumor-associated antigen (melanoma) identified by monoclonal antibodies 133.2 and 96.5,involved in cellular iron uptake. | Melanotransferrin, P97 | Transferrin superfamily |
| CD229 | Lymphocytes | 90–120 | May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction | Ly9 | Immunoglobulin superfamily (CD2 subfamily) |
| CD230 | Expressed both in normal and infected cells | 27–30 | The function of PRP is not known. It is encoded in the host genome found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) | CJD, PRIP, prion protein (p27–30) | Prion family |
| CD231 | T-cell acute lymphoblastic leukemia, neuroblastoma cells and normal brain neuron | 150 | The function of CD231 is currently unknown. It is cell-surface glycoprotein which is a specific marker for T-cell acute lymphoblastic leukemia. Also found on neuroblastomas | TALLA-1, TM4SF2, A15, MXS1, CCG-B7 | Transmembrane 4 superfamily (TM4SF also known as tetraspanins) |
| CD232 | Nonlineage molecules | 200 | Receptor for an immunologically active semaphorin (virus-encoded semaphorin protein receptor) | VESPR, PLXN, PLXN-C1 | Plexin family |
| CD233 | Erythroid cells | 93 | Band 3 is the major integral glycoprotein of the erythrocyte membrane. It has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Multifunctional transport protein | SLC4A1, Diego blood group, D1, AE1, EPB3 | Anion exchanger family |
| CD234 | Erythroid cells and nonerythroid cells | 35 | Fy-glycoprotein; Duffy blood group antigen; nonspecific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi plays a role in inflammation and in malaria infection | GPD, CCBP1, DARC (duffy antigen/receptor for chemokines) | Family 1 of G protein-coupled receptors, chemokine receptors superfamily |
| CD235a | Erythroid cells | 31 | Major carbohydrate rich sialoglycoprotein of human erythrocyte membrane which bears the antigenic determinants for the MN and Ss blood groups. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors and also binds influenza virus | Glycophorin A, GPA, MNS | Glycophorin A family |
| CD235b | Erythroid cells | GYPD is smaller than GYPC (24 kD vs 32 kD) | This protein is a minor sialoglycoprotein in human erythrocyte membranes. Along with GYPA, GYPB is responsible for the MNS blood group system. The Ss blood group antigens are located on glycophorin B | Glycophorin B, MNS, GPB | Glycophorin A family |
| CD236 | Erythroid cells | 24 | Glycophorin C (GPC) and glycophorin D (GPD) are closely related sialoglycoproteins in the human red blood cell (RBC) membrane. GPD is a ubiquitous shortened isoform of GPC, produced by alternative splicing of the same gene. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene | Glycophorin D, GPD, GYPD | Type III membrane proteins |
| CD236R | Erythroid cells | 32 | Glycophorin C (GPC) is associated with the Gerbich (Ge) blood group deficiency. It is a minor red cell-membrane component, representing about 4% of the membrane sialoglycoproteins, but shows very little homology with the major red cell-membrane glycophorins A and B. It plays an important role in regulating the mechanical stability of red cells and is a putative receptor for the merozoites of Plasmodium falciparum | Glycophorin C, GYPC, GPC | Type III membrane proteins |
| CD238 | Erythroid cells | 93 | KELL blood group antigen; homology to a family of zinc metalloglycoproteins with neutral endopeptidase activity, type II transmembrane glycoprotein | KELL | Belongs to peptidase family m13 (zinc metalloprotease); also known as the neprilysin subfamily |
| CD239 | Erythroid cells | 78 | A type I membrane protein.The human F8/G253 antigen, B-CAM, is a cell surface glycoprotein that is expressed with restricted distribution pattern in normal fetal and adult tissues, and is upregulated following malignant transformation in some cell types. Its overall structure is similar to that of the human tumor marker MUC 18 and the chicken neural adhesion molecule SC1 | B-CAM (B-cell adhesion molecule), LU, Lutheran blood group | Immunoglobulin superfamily |
| CD240CE | Erythroid cells | 45.5 | Rhesus blood group, CcEe antigens. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. It is highly hydrophobic and deeply buried within the phospholipid bilayer | RHCE, RH30A, RHPI, Rh4 | Rh family |
| CD240D | Erythroid cells | 45.5 (product—30) | Rhesus blood group, D antigen. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Absent in the Caucasian RHD-negative phenotype | RhD, Rh4, RhPI, RhII, Rh30D | Rh family |
| CD241 | Erythroid cells | 50 | Rhesus blood group-associated glycoprotein RH50, component of the RH antigen multisubunit complex; required for transport and assembly of the Rh membrane complex to the red blood cell surface. highly homologous to RH, 30kD components. Defects in RhAg are a cause of a form of chronic hemolytic anemia associated with stomatocytosis, and spherocytosis, reduced osmotic fragility, and increased cation permeability | RhAg, RH50A | Rh family |
| CD242 | Erythroid cells | 42 | Intercellular adhesion molecule 4, Landsteiner-Wiener blood group. LW molecules may contribute to the vasoocclusive events associated with episodes of acute pain in sickle cell disease | ICAM-4, LW | Immunoglobulin superfamily, intercellular adhesion molecules (ICAMs) |
| CD243 | Stem/progenitor cells | 170 | Multidrug resistance protein 1 (P-glycoprotein). P-gp has been shown to utilise ATP to pump hydrophobic drugs out of cells, thus increasing their intracellular concentration and hence their toxicity. The MDR 1 gene is amplified in multidrug resistant cell lines | MDR-1, p-170 | ABC superfamily of ATP-binding transport proteins |
| CD244 | NK cells | 66 | 2B4 is a cell-surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T-lymphocyte function. It appears that the primary function of 2B4 is to modulate other receptorligand interactions to enhance leukocyte activation | 2B4, NK cell activation inducing ligand (NAIL) | Immunoglobulin superfamily |
| CD245 | T cells | 220–240 | Cyclin E/Cdk2 interacting protein p220. NPAT is involved in a key S phase event and links cyclical cyclin E/Cdk2 kinase activity to replication-dependent histone gene transcription.NPAT gene may be essential for cell maintenance and may be a member of the housekeeping genes | NPAT | |
| CD246 | Expressed in the small intestine, testis, and brain but not in normal lymphoid cells | 177 kDa; after glycosylation, produces a 200 kDa mature glycoprotein | Anaplastic (CD30+ large cell) lymphoma kinase; plays an important role in brain development, involved in anaplastic nodal non Hodgkin lymphoma or Hodgkin's disease with translocation t(2;5)(p23;q35) or inv2(23;q35). Oncogenesis via the kinase function is activated by oligomerization of NPM1-ALK mediated by the NPM1 part | ALK | Insulin receptor family of tyrosine-protein kinases |
| CD247 | T cells, NK cells | 16 | T-cell receptor ζ; has a probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. TCRζ together with TCRα:β and γ:δ heterodimers and CD3-γ, -δ, and -ε, forms the TCR-CD3 complex. The ζ chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response | ζ chain, CD3Z | Immunoglobulin superfamily |
Complied by Laura Herbert, Royal Free Hospital, London. Data based on CD designations made at the 7th Workshop on Human Leucocyte Differentiation Antigens, provided by Protein Reviews on the Web (http://www
.ncbi.nlm.nih.gov/prow/).
- Appendix II. CD Antigens - ImmunobiologyAppendix II. CD Antigens - Immunobiology
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