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Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001.

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Immunobiology: The Immune System in Health and Disease. 5th edition.

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Appendix II. CD Antigens

Appendix II. CD antigens

CD antigenCellular expressionMolecular weight (kDa) FunctionsOther namesFamily relationships
CD1a,b,c,dCortical thymocytes, Langerhans' cells, dendritic cells, B cells (CD1c), intestinal epithelium, smooth muscle, blood vessels (CD1d) 43–49MHC class I-like molecule, associated with β 2 -microglobulin. Has specialized role in presentation of lipid antigens Immunoglobulin
CD2T cells, thymocytes, NK cells 45–58Adhesion molecule, binding CD58 (LFA-3). Binds Lck intracellularly and activates T cellsT11, LFA-2 Immunoglobulin
CD3Thymocytes, T cells γ:25–28, δ:20, ε:20Associated with the T-cell antigen receptor (TCR). Required for cellsurface expression of and signal transduction by the TCRT3 Immunoglobulin
CD4Thymocyte subsets, T H 1 and T H 2 T cells (about two thirds of peripheral T cells), monocytes, macrophages55Co-receptor for MHC class II molecules. Binds Lck on cytoplasmic face of membrane. Receptor for HIV-1 and HIV-2 gp120T4, L3T4 Immunoglobulin
CD5Thymocytes, T cells, subset of B cells67T1, Ly1Scavenger receptor
CD6Thymocytes, T cells, B cells in chronic lymphatic leukemia 100–130Binds CD166T12Scavenger receptor
CD7 Pluripotential hematopoietic cells, thymocytes, T cells40Unknown, cytoplasmic domain binds PI 3-kinase on cross-linking. Marker for T cell acute lymphatic leukemia and pluripotential stem cell leukemias Immunoglobulin
CD8Thymocytes subsets, cytotoxic T cells (about one third of peripheral T cells)α: 32–34, β:32–34Co-receptor for MHC class I molecules. Binds Lck on cytoplasmic face of membraneT8, Lyt2,3 Immunoglobulin
CD9Pre-B cells, monocytes, eosinophils, basophils, platelets, activated T cells, brain and peripheral nerves, vascular smooth muscle24Mediates platelet aggregation and activation via FcγRIIa, may play a role in cell migration Tetraspanning membrane protein, also called transmembrane 4 (TM4)
CD10B- and T-cell precursors, bone marrow stromal cells100Zinc metalloproteinase, marker for pre-B acute lymphatic leukemia (ALL)Neutral endopeptidase, common acute lymphocytic leukemia antigen (CALLA)
CD11aLymphocytes, granulocytes, monocytes and macrophages180αL subunit of integrin LFA-1 (associated with CD18); binds to CD54 (ICAM-1), CD102 (ICAM-2), and CD50 (ICAM-3) LFA-1Integrin α
CD11bMyeloid and NK cells170αM subunit of integrin CR3 (associated with CD18): binds CD54, complement component iC3b, and extracellular matrix proteins Mac-1Integrin α
CD11cMyeloid cells150αX subunit of integrin CR4 (associated with CD18); binds fibrinogenCR4, p150, 95Integrin α
CD11d Leukocytes125αD subunits of integrin; associated with CD18; binds to CD50Integrin α
CDw12Monocytes, granulocytes, platelets 90–120 Unknown
CD13 Myelomonocytic cells 150–170Zinc metalloproteinase Aminopeptidase N
CD14 Myelomonocytic cells 53–55Receptor for complex of lipopolysaccharide and lipopolysaccharide binding protein (LBP)
CD15Neutrophils, eosinophils, monocytesTerminal trisaccharide expressed on glycolipids and many cell-surface glycoproteinsLewisx (Lex)
CD15sLeukocytes, endotheliumLigand for CD62E, PSialyl-Lewisx (sLex) poly-N-acetyllactosamine
CD15uSulphated CD15Carbohydrate structures
CD16Neutrophils, NK cells, macrophages 50–80Component of low affinity Fc receptor, FcγRIII, mediates phagocytosis and antibody-dependent cell-mediated cytotoxicity FcγRIII Immunoglobulin
CDw17Neutrophils, monocytes, plateletsLactosyl ceramide, a cell-surface glycosphingolipid
CD18 Leukocytes95Intergrin β2 subunit, associates with CD11a, b, c, and dIntegrin β
CD19B cells95Forms complex with CD21 (CR2) and CD81 (TAPA-1); co-receptor for B cells—cytoplasmic domain binds cytoplasmic tyrosine kinases and PI 3-kinase Immunoglobulin
CD20B cells 33–37Oligomers of CD20 may form a Ca 2+ channel; possible role in regulating B-cell activationContains 4 transmembrane segments
CD21Mature B cells, follicular dendritic cells145Receptor for complement component C3d, Epstein-Barr virus. With CD19 and CD81, CD21 forms co-receptor for B cellsCR2Complement control protein (CCP)
CD22Mature B cellsα: 130, β:140Binds sialoconjugates BL-CAM Immunoglobulin
CD23Mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets45Low-affinity receptor for lgE, regulates lgE synthesis; ligand for CD19:CD21:CD81 co-receptor FcεRIIC-type lectin
CD24B cells, granulocytes 35–45 UnknownPossible human homologue of mouse heat stable antigen (HSA)
CD25Activated T cells, B cells, and monocytes55IL-2 receptor α chainTacCCP
CD26Activated B and T cells, macrophages110 Exopeptidase, cleaves N terminal X-Pro or X-Ala dipeptides from polypeptidesDipeptidyl peptidase IVType II transmembrane glycoprotein
CD27Medullary thymocytes, T cells, NK cells, some B cells55Binds CD70; can function as a co-stimulator for T and B cellsTNF receptor
CD28T-cell subsets, activated B cells44Activation of naive T cells, receptor for co-stimulatory signal (signal 2) binds CD80 (B7.1) and CD86 (B7.2)Tp44 Immunoglobulin and CD86 (B7.2)
CD29 Leukocytes130Integrin β1 subunit, associates with CD49a in VLA-1 integrinIntegrin β
CD30Activated T, B, and NK cells, monocytes120Binds CD30L (CD153); cross-linking CD30 enhances proliferation of B and T cellsKi-1TNF receptor
CD31Monocytes, platelets, granulocytes, T-cell subsets, endothelial cells 130–140Adhesion molecule, mediating both leukocyte-endothelial and endothelial-endothelial interactions PECAM-1 Immunoglobulin
CD32Monocytes, granulocytes, B cells, eosinophils40Low affinity Fc receptor for aggregated immunoglobulin:immune complexes FcγRIII Immunoglobulin
CD33Myeloid progenitor cells, monocytes67Binds sialoconjugates Immunoglobulin
CD34 Hematopoietic precursors, capillary endothelium 105–120Ligand for CD62L (L-selectin) Mucin
CD35 Erythrocytes, B cells, monocytes, neutrophils, eosinophils, follicular dendritic cells250Complement receptor 1, binds C3b and C4b, mediates phagocytosisCR1CCP
CD36Platelets, monocytes, endothelial cells88Platelet adhesion molecule; involved in recognition and phagocytosis of apoptosed cellsPlatelet GPIV, GPIIIb
CD37Mature B cells, mature T cells, myeloid cells 40–52Unknown, may be involved in signal transduction; forms complexes with CD53, CD81, CD82, and MHC class II Transmembrane 4
CD38Early B and T cells, activated T cells, germinal center B cells, plasma cells45NAD glycohydrolase, augments B cell proliferationT10
CD39Activated B cells, activated NK cells, macrophages, dendritic cells78Unknown, may mediate adhesion of B cells
CD40B cells, macrophages, dendritic cells, basal epithelial cells48Binds CD154 (CD40L); receptor for co-stimulatory signal for B cells, promotes growth, differentiation, and isotype switching of B cells, and cytokine production by macrophages and dendritic cellsTNF receptor
CD41Platelets, megakaryocytes Dimer: GPIIba:125, GPIIbb:22αIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor, and thrombospondin GPIIbIntegrin α
CD42a,b,c,dPlatelets, megakaryocytesa: 23; b: 135, 23; c: 22; d: 85Binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injurya: GPIX; b: GPIbα; c: GPIbβ; d: GPVLeucine-rich repeat
CD43Leukocytes, except resting B cells 115–135; 95–115 (T cells) (neutrophils)Has extended structure, approx. 45 nm long and may be anti-adhesiveLeukosialin, sialophorin Mucin
CD44Leukocytes, erythrocytes 80–95Binds hyaluronic acid, mediates adhesion of leukocytesHermes antigen, Pgp-1Link protein
CD45All hematopoietic cells 180–240 (multiple isoforms)Tyrosine phosphatase, augments signaling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below)Leukocyte common antigen (LCA), T200, B220Fibronectin type III
CD45ROT-cell subsets, B-cell subsets, monocytes, macrophages180Isoform of CD45 containing none of the A, B, and C exonsFibronectin type II
CD45RAB cells, T-cell subsets (naive T cells), monocytes 205–220Isoforms of CD45 containing the A exonFibronectin type II
CD45RBT-cell subsets, B cells, monocytes, macrophages, granulocytes 190–220Isoforms of CD45 containing the B exonT200Fibronectin type II
CD46 Hematopoietic and nonhematopoietic nucleated cells56/66 (splice variants)Membrane co-factor protein, binds to C3b and C4b to permit their degradation by Factor IMCPCCP
CD47All cells 47–52Adhesion molecule, thrombospondin receptorIAP, MER6, OA3 Immunoglobulin superfamily
CD48 Leukocytes 40–47Putative ligand for CD244 Blast-1 Immunoglobulin
CD49aActivated T cells, monocytes, neuronal cells, smooth muscle200α1 integrin, associates with CD29, binds collagen, laminin-1 VLA-1Integrin α
CD49bB cells, monocytes, platelets, megakaryocytes, neuronal, epithelial and endothelial cells, osteoclasts160α2 integrin, associates with CD29, binds collagen, lamininVLA-2, platelet GPIaIntegrin α
CD49cB cells, many adherent cells125, 30α3 integrin, associates with CD29, binds laminin-5, fibronectin, collagen, entactin, invasin VLA-3Integrin α
CD49dBroad distribution includes B cells, thymocytes, monocytes, granulocytes, dendritic cells150α4 integrin, associates with CD29, binds fibronectin, MAdCAM-1, VCAM-1 VLA-4Integrin α
CD49eBroad distribution includes memory T cells, monocytes, platelets135, 25α5 integrin, associates with CD29, binds fibronectin, invasin VLA-5Integrin α
CD49fT lymphocytes, monocytes, platelets, megakaryocytes, trophoblasts125, 25α6 integrin, associates with CD29, binds laminin, invasin, merosine VLA-6Integrin α
CD50Thymocytes, T cells, B cells, monocytes, granulocytes130Binds integrin CD11a/CD18 ICAM-3 Immunoglobulin
CD51Platelets, megakaryocytes125, 24αV integrin, associates with CD61, binds vitronectin, von Willebrand factor, fibrinogen, and thrombospondin; may be receptor for apoptotic cellsVitronectin receptorIntegrin α
CD52Thymocytes, T cells, B cells (not plasma cells), monocytes, granulocytes, spermatozoa25Unknown, target for antibodies used therapeutically to deplete T cells from bone marrowCAMPATH-1, HE5
CD53 Leukocytes 35–42 UnknownMRC OX44 Transmembrane 4
CD54 Hematopoietic and nonhematopoietic cells 75–115 Intercellular adhesion molecule (ICAM)-1 binds CD11a/CD18 integrin (LFA-1) and CD11b/CD18 integrin (Mac-1), receptor for rhinovirus ICAM-1 Immunoglobulin
CD55 Hematopoietic and nonhematopoietic cells 60–70Decay accelerating factor (DAF), binds C3b, disassembles C3/C5 convertaseDAFCCP
CD56NK cells 135–220Isoform of neural cell-adhesion molecule (NCAM), adhesion molecule NKH-1 Immunoglobulin
CD57NK cells, subsets of T cells, B cells, and monocytes Oligosaccharide, found on many cell-surface glycoproteinsHNK-1, Leu-7
CD58 Hematopoietic and nonhematopoietic cells 55–70Leukocyte function-associated antigen-3 (LFA-3), binds CD2, adhesion molecule LFA-3 Immunoglobulin
CD59 Hematopoietic and nonhematopoietic cells19Binds complement components C8 and C9, blocks assembly of membrane attack complexProtectin, Mac inhibitorLy-6
CD60aDisialyl ganglioside D3 (GD3)Carbohydrate structures
CD60b9- O -acetyl-GD3Carbohydrate structures
CD60c7- O -acetyl-GD3Carbohydrate structures
CD61Platelets, megakaryocytes, macrophages110Intergrin β3 subunit, associates with CD41 (GPIIb/IIIa) or CD51 (vitronectin receptor)Integrin β
CD62E Endothelium140Endothelium leukocyte adhesion molecule (ELAM), binds sialyl-Lewis x , mediates rolling interaction of neutrophils on endotheliumELAM-1, E-selectinC-type lectin, EGF, and CCP
CD62LB cells, T cells, monocytes, NK cells150Leukocyte adhesion molecule (LAM), binds CD34, GlyCAM, mediates rolling interactions with endotheliumLAM-1, L-selectin, LECAM-1C-type lectin, EGF, and CCP
CD62PPlatelets, megakaryocytes, endothelium140Adhesion molecule, binds CD162 (PSGL-1), mediates interaction of platelets with endothelial cells, monocytes and rolling leukocytes on endotheliumP-selectin, PADGEMC-type lectin, EGF, and CCP
CD63Activated platelets, monocytes, macrophages53Unknown, is lysosomal membrane protein translocated to cell surface after activationPlatelet activation antigen Transmembrane 4
CD64Monocytes, macrophages72 High-affinity receptor for lgG, binds IgG3>IgG1>IgG4>>>IgG2, mediates phagocytosis, antigen capture, ADCC FcγRI Immunoglobulin
CD65Myeloid cells Oligosaccharide component of a ceramide dodecasaccharide
CD66a Neutrophils 160–180Unknown, member of carcino-embryonic antigen (CEA) family (see below)Biliary glycoprotein-1 (BGP-1) Immunoglobulin
CD66b Granulocytes 95–100Unknown, member of carcinoembryonic antigen (CEA) familyPreviously CD67 Immunoglobulin
CD66cNeutrophils, colon carcinoma90Unknown, member of carcinoembryonic antigen (CEA) familyNonspecific cross-reacting antigen (NCA) Immunoglobulin
CD66d Neutrophils30Unknown, member of carcinoembryonic antigen (CEA) family Immunoglobulin
CD66eAdult colon epithelium, colon carcinoma 180–200Unknown, member of carcinoembryonic antigen (CEA) family Carcinoembryonic antigen (CEA) Immunoglobulin
CD66f UnknownUnknown, member of carcinoembryonic antigen (CEA) familyPregnancy specific glycoprotein Immunoglobulin
CD68Monocytes, macrophages, neutrophils, basophils, large lymphocytes110 Unknown Macrosialin Mucin
CD69Activated T and B cells, activated macrophages and NK cells28, 32 homodimerUnknown, early activation antigenActivation inducer molecule (AIM)C-type lectin
CD70Activated T and B cells, and macrophages75, 95, 170Ligand for CD27, may function in co-stimulation of B and T cells Ki-24TNF
CD71All proliferating cells, hence activated leukocytes95 homodimerTransferrin receptorT9
CD72B cells (not plasma cells)42 homodimer Unknown Lyb-2C-type lectin
CD73B-cell subsets, T-cell subsets69 Ecto-5′-nucleotidase, dephosphorylates nucleotides to allow nucleoside uptake
CD74B cells, macrophages, monocytes, MHC class II positive cells33, 35, 41, 43 (alternative initiation and splicing)MHC class II-associated invariant chainIi, Iγ
CD75Mature B cells, T-cells subsets Lactosamines, ligand for CD22, mediates B-cell-B-cell adhesion
CD75s α-2,6-sialylated lactosaminesCarbohydrate structures
CD77Germinal center B cellsNeutral glycosphingolipid (Galα1→4Galβ1→4Galcβ1 →ceramide), binds Shiga toxin, cross-linking induces apoptosis Globotriaocyl-ceramide (Gb3) Pk blood group
CD79α,βB cellsα: 40–45, β:37Components of B-cell antigen receptor analogous to CD3, required for cell-surface expression and signal transductionIgα, Igβ Immunoglobulin
CD80B-cell subset60 Co-stimulator, ligand for CD28 and CTLA-4B7 (now B7.1), BB1 Immunoglobulin
CD81 Lymphocytes26Associates with CD19, CD21 to form B cell co-receptorTarget of antiproliferative antibody (TAPA-1) Transmembrane 4
CD82 Leukocytes 50–53 UnknownR2 Transmembrane 4
CD83Dendritic cells, B cells, Langerhans' cells43 UnknownHB15 Immunoglobulin
CDw84Monocytes, platelets, circulating B cells73 UnknownGR6 Immunoglobulin
CD85Dendritic cellsILT/LIR familyGR4 Immunoglobulin superfamily
CD86Monocytes, activated B cells, dendritic cells80Ligand for CD28 and CTLA4B7.2 Immunoglobulin
CD87 Granulocytes, monocytes, macrophages, T cells, NK cells, wide variety of nonhematopoietic cell types 35–59Receptor for urokinase plasminogen activatoruPARLy-6
CD88 Polymorphonuclear leukocytes, macrophages, mast cells43Receptor for complement component C5aC5aRG protein-coupled receptor
CD89Monocytes, macrophages, granulocytes, neutrophils, B-cell subsets, T-cell subsets 50–70IgA receptor FcαR Immunoglobulin
CD90CD34 + prothymocytes (human), thymocytes, T cells (mouse)18 Unknown Thy-1 Immunoglobulin
CD91Monocytes, many nonhematopoietic cells515, 85 α2-macroglobulin receptorEGF, LDL receptor
CD92Neutrophils, monocytes,platelets,endothelium70 UnknownGR9
CD93Neutrophils, monocytes,endothelium120 UnknownGR11
CD94T-cell subsets, NK cells43 UnknownKP43C-type lectin
CD95Wide variety of cell lines, in vivo distribution uncertain45Binds TNF-like Fas ligand,induces apoptosisApo-1, FasTNF receptor
CD96Activated T cells, NK cells160 UnknownT-cell activation increased late expression (TACTILE) Immunoglobulin
CD97Activated B and T cells, monocytes, granulocytes 75–85Binds CD55GR1EGF, G proteincoupled receptor
CD98T cells, B cells, natural killer cells, granulocytes, all human cell lines80, 45 heterodimerMay be amino acid transporter4F2, FRP-1
CD99Peripheral blood lymphocytes, thymocytes32 UnknownMIC2, E2
CD100 Hematopoietic cells150 homodimer UnknownGR3 Semaphorin
CD101Monocytes, granulocytes, dendritic cells, activated T cells120 homodimer Unknown BPC#4 Immunoglobulin
CD102Resting lymphocytes, monocytes, vascular endothelium cells (strongest) 55–65Binds CD11a/CD18 (LFA-1) but not CD11b/CD18(Mac-1) ICAM-2 Immunoglobulin
CD103 Intraepithelial lymphocytes, 2–6% peripheral blood lymphocytes150, 25αE integrinHML-1, α6,αE, integrinIntegrin α
CD104CD4 - CD8 - thymocytes, neuronal, epithelial, and some endothelial cells, Schwann cells, trophoblasts220Integrin β4 associates with CD49f, binds lamininsβ4 integrinIntegrin β
CD105Endothelial cells, activated monocytes and macrophages, bone marrow cell subsets90 homodimerBinds TGF-β Endoglin
CD106Endothelial cells 100–110Adhesion molecule, ligand for VLA-4 (α 4 β 1 integrin) VCAM-1 Immunoglobulin
CD107aActivated platelets, activated T cells, activated neutrophils, activated endothelium110Unknown, is lysosomal membrane protein translocated to the cell surface after activationLysosomal associated membrane protein-1 (LAMP-1)
CD107bActivated platelets, activated T cells, activated neutrophils, activated endothelium120Unknown, is lysosomal membrane protein translocated to the cell surface after activation LAMP-2
CD108 Erythrocytes, circulating lymphocytes, lymphoblasts80 UnknownGR2, John Milton-Hagen blood group antigen
CD109Activated T cells, activated platelets, vascular endothelium170 UnknownPlatelet activation factor, GR56
CD110 PlateletsMPL, TPO R
CD111Myeloid cells PPR1/Nectin1
CD112Myeloid cellsPRR2
CD114 Granulocytes, monocytes150Granulocytes colony-stimulating factor (G-CSF) receptor Immunoglobulin,fibronectin type III
CD115Monocytes, macrophages150Macrophage colony-stimulating factor (M-CSF) receptorM-CSFR, c-fms Immunoglobulin, tyrosine kinase
CD116Monocytes, neutrophils, eosinophils, endothelium 70–85 Granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor α chain GM-CSFRαCytokine receptor, fibronectin type III
CD117 Hematopoietic progenitors145Stem-cell factor (SCF) receptor c-kit Immunoglobulin, tyrosine kinase
CD118Broad cellular expression Interferon-α, β receptorIFN-α, βR
CD119Macrophages, monocytes, B cells, endothelium 90–100 Interferon-γ receptor IFN-γRFibronectin type III
CD120a Hematopoietic and nonhematopoietic cells, highest on epithelial cells 50–60TNF receptor, binds both TNF-α and TNF TNFR-ITNF receptor
CD120b Hematopoietic and nonhematopoietic cells, highest on myeloid cells 75–85TNF receptor, binds both TNF-α and TNF TNFR-IITNF receptor
CD121aThymocytes, T cells80Type I interleukin-1 receptor, binds IL-1α and ILIL-1R type I Immunoglobulin
CDw121bB cells, macrophages, monocytes 60–70Type II interleukin-1 receptor, binds IL-1α and IL-1βIL-1R type II Immunoglobulin
CD122NK cells, resting T-cell subsets, some B-cell lines75IL-2 receptor β chain IL-2RβCytokine receptor, Fibronectin type III
CD123Bone marrow stem cells, granulocytes, monocytes, megakaryocytes70IL-3 receptor α chain IL-3RαCytokine receptor, Fibronectin type III
CD124Mature B and T cells, hematopoietic precursor cells 130–150IL-4 receptor IL-4RCytokine receptor, Fibronectin type III
CD125Eosinophils, basophils, activated B cells 55–60IL-5 receptor IL-5RCytokine receptor, Fibronectin type III
CD126Activated B cells and plasma cells (strong), most leukocytes (weak)80IL-6 receptor α subunit IL-6Rα Immunoglobulin, Cytokine receptor, Fibronectin type III
CD127Bone marrow lymphoid precursors, pro-B cells, mature T cells, monocytes68–79, possibly forms homodimersIL-7 receptor IL-7RFibronectin type III
CDw128Neutrophils, basophils, T-cell subsets 58–67IL-8 receptor IL-8RG protein-coupled receptor
CD129Not yet assigned
CD130Most cell types, strong on activated B cells and plasma cells130Common subunit of IL-6, IL-11, oncostain-M (OSM) and leukemia inhibitory factor (LIF) receptorsIL-6Rβ, IL-11Rβ,OSMRβ, LIFRβ, IFRβ Immunoglobulin, Cytokine receptor, Fibronectin type III
CDw131Myeloid progenitors, granulocytes140Common β subunit of IL-3, IL-5, and GM-CSF receptorsIL-3Rβ, IL-5Rβ,GM-CSFRβCytokine receptor, Fibronectin type III
CD132B cells, T cells, NK cells, mast cells, neutrophils64IL-2 receptor γ chain, common subunit of IL-2, IL-4, IL-7, IL-9 and IL-15 receptorsCytokine receptor
CD133 Stem/progenitor cells AC133
CD134Activated T cells50May acts as adhesion molecule costimulatorOX40TNF receptor
CD135 Multipotential precursors, myelomonocytic and B-cell progenitors130, 155Growth factor receptorFLK2, STK-1 Immunoglobulin, Tyrosine kinase
CDw136Monocytes, epithelial cells, central and peripheral nervous system180Chemotaxis, phagocytosis, cell growth, and differentiationMSP-R, RONTyrosine kinase
CDw137T and B lymphocytes, monocytes, some epithelial cells Co-stimulator of T-cell proliferationILA (induced by lymphocyte activation), 4–1BBTNF receptor
CD138B cellsHeparan sulphate proteoglycan binds collagen type I Syndecan-1
CD139B cells209, 228 Unknown
CD140a,bStromal cells, some endothelial cellsa: 180, b: 180Platelet derived growth factor (PDGF) receptor α and β chains
CD141Vascular endothelial cells105 Anticoagulant, binds thrombin, the complex then activates protein C Thrombomodulin fetomodulinC-type lectin, EGF
CD142Epidermal keratinocytes, various epithelial cells, astrocytes, Schwann cells. Absent from cells in direct contact with plasma unless induced by inflammatory mediators 45–47Major initiating factor of clotting. Binds Factor VIIa; this complex activates Factors VII, IX, and XTissue factor, thromboplastinFibronectin type III
CD143Endothelial cells, except large blood vessels and kidney, epithelial cells of brush borders of kidney and small intestine, neuronal cells, activated macrophages and some T cells. Soluble form in plasma 170–180Zn 2+ metallopeptidase dipeptidyl peptidase, cleaves angiotensin I and bradykinin from precursor formsAngiotensin converting enzyme (ACE)
CD144Endothelial cells130Organizes adherens junction in endothelial cellsCadherin-5, VE-cadherin Cadherin
CD145Endothelial cells, some stromal cells25, 90, 110 Unknown
CD146 Endothelium130Potential adhesion molecule, localized at cell-cell junctionsMCAM, MUC18, S-ENDO Immunoglobulin
CD147Leukocytes, red blood cells, platelets, endothelial cells 55–65Potential adhesion moleculeM6, neurothelin, EMMPRIN, basigin, OX-47 Immunoglobulin
CD148 Granulocytes, monocytes, dendritic cells, T cells, fibroblasts, nerve cells 240–260Contact inhibition of cell growth HPTPηFibronectin type III, protein tyrosine phosphatase
CD150Thymocytes, activated lymphocytes 75–95 UnknownSLAM Immunoglobulin
CD151Platelets, megakaryocytes, epithelial cells, endothelial cells32Associates with β1 integrinsPETA-3, SFA-1 Transmembrane 4
CD152Activated T cells33Receptor for B7.1 (CD80), B7.2 (CD86); negative regulator of T-cell activation CTLA-4 Immunoglobulin
CD153Activated T cells, activated macrophages, neutrophils, B cells 38–40Ligand for CD30, may co-stimulate T cells CD30LTNF
CD154Activated CD4 T cells30 trimerLigand for CD40, inducer of B cell proliferation and activationCD40L, TRAP, T-BAM, gp39TNF receptor
CD155Monocytes, macrophages, thymocytes, CNS neurons 80–90Normal function unknown; receptor for poliovirusPoliovirus receptor Immunoglobulin
CD156aNeutrophils, monocytes69Unknown, may be involved in integrin leukocyte extravasationMS2, ADAM 8 (A disintegrin and metallo-protease)
CD156bTACE/ADAM17. Adhesion structures
CD157 Granulocytes, monocytes, bone marrow stromal cells, vascular endothelial cells, follicular dendritic cells42–45 (50 on monocytes)ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase BST-1
CD158NK cellsKIR family
CD158aNK-cell subsets50 or 58Inhibits NK cell cytotoxicity on binding MHC class I moleculesp50.1, p58.1 Immunoglobulin
CD158bNK-cell subsets50 or 58Inhibits NK cell cytotoxicity on binding HLA-Cw3 and related allelesp50.2, p58.2 Immunoglobulin
CD159aNK cellsBinds CD94 to form NK receptor; inhibits NK cell cytotoxicity on binding MHC class I moolecules NKG2A
CD160T cellsBY55
CD161NK cells, T cells44Regulates NK cytotoxicity NKRP1C-type lectin
CD162Neutrophils, lymphocytes, monocytes120 homodimerLigand for CD62P PSGL-1 Mucin
CD162RNK cellsPEN5
CD163Monocytes, macrophages130 UnknownM130
CD164Epithelial cells, monocytes, bone marrow stromal cells80 UnknownMUC-24 (multi-glycosylated protein 24) Mucin
CD165Thymocytes, thymic epithelial cells, CNS neurons, pancreatic islets, Bowman's capsule37Adhesion between thymocytes and thymic epitheliumGp37, AD2
CD166Activated T cells, thymic epithelium, fibroblasts, neurons 100–105Ligand for CD6, involved integrin neurite extensionALCAM, BEN, DM-GRASP, SC-1 Immunoglobulin
CD167aNormal and transformed epithelial cells63, 64 dimerBinds collagenDDR1, trkE, cak, eddr1Receptor tyrosine kinase, discoidin-related
CD168Breast cancer cellsFive isoforms: 58, 60, 64, 70, 84Adhesion molecule. Receptor for hyaluronic acid-mediated motility—mediated cell migration RHAMM
CD169Subsets of macrophages185Adhesion molecule. Binds sialylated carbohydrates. May mediate macrophage binding to granulocytes and lymphocytes Sialoadhesin Immunoglobulin superfamily, sialoadhesin family
CD170 Neutrophils67 homodimerAdhesion molecule. S ialic acid-binding I g-like lec tin (Siglec). Cytoplasmic tail contains ITIM motifsSiglec-5, OBBP2, CD33L2 Immunoglobulin superfamily, sialoadhesin family
CD171Neurons, Schwann cells, lymphoid and myelomonocytic cells, B cells, CD4 T cells (not CD8 T cells) 200–220, exact MW varies with cell typeAdhesion molecule, binds CD9, CD24, CD56, also homophilic bindingL1, NCAM-L1 Immunoglobulin superfamily
CD172a 115–120Adhesion molecule; the transmembrane protein is a substrate of activated receptor tyrosine kinases (RTKs) and binds to SH2 domainsSIRP, SHPS1, MYD-1, SIRP-α-1, protein tyrosine phosphatase, nonreceptor type substrate 1 (PTPNS1) Immunoglobulin superfamily
CD173All cellsBlood group H type 2. Carbohydrate moiety
CD174All cellsLewis y Blood group. Carbohydrate moiety
CD175All cellsTn Blood group. Carbohydrate moiety
CD175sAll cellsSialyl-Tn Blood group. Carbohydrate moiety
CD176All cellsTF Blood group. Carbohydrate moiety
CD177Myeloid cells 56-64NB1 is a GPI-linked neutrophil-specific antigen, found on only a subpopulation of neutrophils present in NB1-positive adults (97% of healthy donors) NB1 is first expressed at the myelocyte stage of myeloid differentiationNB1
CD178Activated T cells 38-42Fas ligand; binds to Fas to induce apoptosisFasLTNF superfamily
CD179aEarly B cells 16–18 Immunoglobulin iota chain associates noncovalently with CD179b to form a surrogate light chain which is a component of the pre-B-cell receptor that plays a critical role in early B-cell differentiationVpreB, IGVPB, IGτ Immunoglobulin superfamily
CD179bB cells22 Immunoglobulin λ-like polypeptide 1 associates noncovalently with CD179a to form a surrogate light chain that is selectively expressed at the early stages of B-cell development. Mutations in the CD179b gene have been shown to result in impairment of B-cell development and agammaglobulinemia in humansIGLL1, λ5 (IGL5), IGVPB, 14. Immunoglobulin superfamily
CD180B cells 95-105Type 1 membrane protein consisting of extracellular leucine-rich repeats (LRR). Is associated with a molecule called MD-1 and forms the cell-surface receptor complex, RP105/MD-1, which by working in concert with TLR4, controls B-cell recognition and signaling of lipopolysaccharide (LPS)LY64, RP105Toll-like receptors (TLR)
CD183Particularly on malignant B cells from chronic lymphoproliferative disorders 46-52CXC chemokine receptor involved in chemotaxis of malignant B lymphocytes. Binds INP10 and MIG3CXCR3, G protein-coupled receptor 9 (GPR 9)Chemokine receptors, G protein-coupled receptor superfamily
CD184 Preferentially expressed on the more immature CD34+ haematopoietic stem cells 46-52Binding to SDF-1 (LESTR/fusin); acts as a cofactor for fusion and entry of T-cell line; trophic strains of HIV-1CXCR4, NPY3R, LESTR, fusin, HM89Chemokine receptors, G protein-coupled receptor superfamily
CD195 Promyelocytic cells40Receptor for a CC type chemokine. Binds to MIP-1α, MIP-1β and RANTES. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as co-receptor with CD4 for primary macrophage-tropic isolates of HIV-1CMKBR5, CCR5, CKR-5, CC-CKR-5, CKR5Chemokine receptors, G protein-coupled receptor superfamily
CDw197Activated B and T lymphocytes, strongly upregulated in B cells infected with EBV and T cells infected with HHV6 or 7 46-52Receptor for the MIP-3β chemokine; probable mediator of EBV effects on B lymphocytes or of normal lymphocyte functionsCCR7. EBI1 (Epstein-Barr virus induced gene 1), CMKBR7, BLR2Chemokine receptors, G protein-coupled receptor superfamily
CD200Normal brain and B-cell lines41 (rat thymocytes) 47 (rat brain)Antigen identified by MoAb MRC OX-2. Nonlineage molecules. Function unknownMOX-2, MOX-1 Immunoglobulin superfamily
CD201Endothelial cells49Endothelial cell-surface receptor (EPCR) that is capable of high-affinity binding of protein C and activated protein C. It is downregulated by exposure of endothelium to tumor necrosis factorEPCRCD1major histocompatibility complex family
CD202bEndothelial cells140Receptor tyrosine kinase, binds angiopoietin-1; important in angiogenesis, particularly for vascular network formation in endothelial cells. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesisVMCM, TEK (tyrosine kinase, endothelial), TIE2 (tyrosine kinase with Ig and EGF homology domains), VMCM1 Immunoglobulin superfamily, tyrosine kinase
CD203cMyeloid cells (uterus, basophils, and mast cells)101Belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. They catalyze the cleavage of phosphodiester and phosphosulfate bonds of a variety of molecules, including deoxynucleotides, NAD, and nucleotide sugarsNPP3, B10, PDNP3, PD-Iβ, gp130RB13-6Type II transmembrane proteins, Ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP) family
CD204Myeloid cells220Mediate the binding, internalization, and processing of a wide range of negatively charged macromolecules. Implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesisMacrophage scavenger R (MSR1)Scavenger receptor family, collagen-like
CD205Dendritic cells205Lymphocyte antigen 75; putative antigen-uptake receptor on dendritic cellsLY75, DEC-205, GP200-MR6Type I transmembrane protein
CD206Macrophages, endothelial cells 175-190Type I membrane glycoprotein; only known example of a C-type lectin that contains multiple C-type CRDs (carbohydrate-recognition domains); it binds high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungiMacrophage mannose receptor (MMR), MRC1C-type lectin superfamily
CD207Langerhans' cells40Type II transmembrane protein; Langerhans' cell specific C-type lectin; potent inducer of membrane superimposition and zippering leading to BG (Birbeck granules) formation LangerinC-type lectin superfamily
CD208 Interdigitating dendritic cells in lymphoid organs 70-90Homologous to CD68, DC-LAMP is a lysosomal protein involved in remodeling of specialized antigen-processing compartments and in MHC class II-restricted antigen presentation. Upregulated in mature DCs induced by CD40L, TNF-α and LPS.D lysosome-associated membrane protein, DC-LAMPMajor histocompatibility complex family
CD209Dendritic cells44C-type lectin; binds ICAM3 and HIV-1 envelope glycoprotein gp120 enables T-cell receptor engagement by stabilization of the DC/T-cell contact zone, promotes efficient infection in trans cells that express CD4 and chemokine receptors; type II transmembrane proteinDC-SIGN (dendritic cellspecific ICAM3-grabbing nonintegrin)C-type lectin superfamily
CDw210B cells, T helper cells, and cells of the monocyte/macrophage lineage 90-110Interleukin 10 receptor α and β IL-10Rα, IL-10RA, HIL-10R, IL-10Rβ, IL-10RB, CRF2-4, CRFB4Class II cytokine receptor family
CD212Activated CD4, CD8, and NK cells130IL-12 receptor β chain; a type I transmembrane protein involved in IL-12 signal transduction.IL-12R IL-12RBHaemopoietin cytokine receptor superfamily
CD213a1B cells, monocytes, fibroblasts, endothelial cells 60-70Receptor which binds II-13 with a low affinity; together with IL-4Rα can form a functional receptor for IL-13, also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL-4 signaling IL-13Rα 1, NR4, IL-13RaHaemopoietic cytokine receptor superfamily
CD213a2B cells, monocytes, fibroblasts, endothelial cellsIL-13 receptor which binds as a monomer with high affinity to interleukin-13 (IL-13), but not to IL-4; human cells expressing IL-13RA2 show specific IL-13 binding with high affinity IL-13Rα 2, IL-13BPHaemopoietic cytokine receptor superfamily
CDw217Activated memory T cells120Interleukin 17 receptor homodimerIL-17R, CTLA-8Chemokine/ cytokine receptors
CD220Nonlineage moleculesα: 130, β:95Insulin receptor; integral transmembrane glycoprotein comprised of two α and two β subunits; this receptor binds insulin and has a tyrosine-protein kinase activity—autophosphorylation activates the kinase activityInsulin receptorInsulin receptor family of tyrosine-protein kinases, EGFR family
CD221Nonlineage moleculesα: 135, β:90Insulin-like growth factor I receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity and plays a critical role in transformation events. Cleavage of the precursor generates α and β subunits.IGF1R, JTK13Insulin receptor family of tyrosine-protein kinases, EGFR family
CD222Nonlineage molecules250Ubiquitously expressed multifunctional type I transmembrane protein. Its main functions include internalization of IGF-II, internalization or sorting of lysosomal enzymes and other M6P-containing proteinsIGF2R, CIMPR, CI-MPR, IGF2R, M6P-R (Mannose-6-phosphate receptor)Mammalian lectins
CD223Activated T and NK cells70Involved in lymphocyte activation; binds to HLA class-II antigens; role in downregulating antigen specific response; close relationship of LAG3 to CD4 Lymphocyteactivation gene 3 LAG-3 Immunoglobulin superfamily
CD224Nonlineage molecules62 (unprocessed precursor) Predominantly a membrane-bound enzyme; plays a key role in the γ-glutamyl cycle, a pathway for the synthesis and degradation of glutathione. This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide γ-glutamyl transferase, GGT1, D22S672 D22S732 γ-glutamyl transferase protein family
CD225Leukocytes and endothelial cells 16–17 Interferon-induced transmembrane protein 1 is implicated in the control of cell growth. It is a component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signalsLeu 13, IFITM1, IFI17IFN-induced transmembrane proteins
CD226NK cells, platelets, monocytes, and a subset of T cells65Adhesion glycoprotein; mediates cellular adhesion to other cells bearing an unidentified ligand and cross-linking CD226 with antibodies causes cellular activationDNAM-1 (PTA1), DNAX, TLiSA1 Immunoglobulin superfamily
CD227Human epithelial tumors, such as breast cancer122 (nonglycosylated)Epithelial mucin containing a variable number of repeats with a length of twenty amino acids, resulting in many different alleles. Direct or indirect interaction with actin cytoskeleton.PUM (peanut-reactive urinary mucin), MUC.1, mucin 1 Mucin
CD228 Predominantly in human melanomas97 Tumor-associated antigen (melanoma) identified by monoclonal antibodies 133.2 and 96.5,involved in cellular iron uptake. Melanotransferrin, P97Transferrin superfamily
CD229 Lymphocytes 90–120May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interactionLy9 Immunoglobulin superfamily (CD2 subfamily)
CD230Expressed both in normal and infected cells 27–30The function of PRP is not known. It is encoded in the host genome found in high quantity in the brain of humans and animals infected with neurodegenerative diseases known as transmissible spongiform encephalopathies or prion diseases (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)CJD, PRIP, prion protein (p27–30)Prion family
CD231T-cell acute lymphoblastic leukemia, neuroblastoma cells and normal brain neuron150The function of CD231 is currently unknown. It is cell-surface glycoprotein which is a specific marker for T-cell acute lymphoblastic leukemia. Also found on neuroblastomasTALLA-1, TM4SF2, A15, MXS1, CCG-B7 Transmembrane 4 superfamily (TM4SF also known as tetraspanins)
CD232Nonlineage molecules200Receptor for an immunologically active semaphorin (virus-encoded semaphorin protein receptor)VESPR, PLXN, PLXN-C1Plexin family
CD233Erythroid cells93Band 3 is the major integral glycoprotein of the erythrocyte membrane. It has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Multifunctional transport proteinSLC4A1, Diego blood group, D1, AE1, EPB3Anion exchanger family
CD234Erythroid cells and nonerythroid cells35 Fy-glycoprotein; Duffy blood group antigen; nonspecific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi plays a role in inflammation and in malaria infectionGPD, CCBP1, DARC (duffy antigen/receptor for chemokines)Family 1 of G protein-coupled receptors, chemokine receptors superfamily
CD235aErythroid cells31Major carbohydrate rich sialoglycoprotein of human erythrocyte membrane which bears the antigenic determinants for the MN and Ss blood groups. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors and also binds influenza virusGlycophorin A, GPA, MNSGlycophorin A family
CD235bErythroid cellsGYPD is smaller than GYPC (24 kD vs 32 kD)This protein is a minor sialoglycoprotein in human erythrocyte membranes. Along with GYPA, GYPB is responsible for the MNS blood group system. The Ss blood group antigens are located on glycophorin BGlycophorin B, MNS, GPBGlycophorin A family
CD236Erythroid cells24Glycophorin C (GPC) and glycophorin D (GPD) are closely related sialoglycoproteins in the human red blood cell (RBC) membrane. GPD is a ubiquitous shortened isoform of GPC, produced by alternative splicing of the same gene. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C geneGlycophorin D, GPD, GYPDType III membrane proteins
CD236RErythroid cells32Glycophorin C (GPC) is associated with the Gerbich (Ge) blood group deficiency. It is a minor red cell-membrane component, representing about 4% of the membrane sialoglycoproteins, but shows very little homology with the major red cell-membrane glycophorins A and B. It plays an important role in regulating the mechanical stability of red cells and is a putative receptor for the merozoites of Plasmodium falciparumGlycophorin C, GYPC, GPCType III membrane proteins
CD238Erythroid cells93KELL blood group antigen; homology to a family of zinc metalloglycoproteins with neutral endopeptidase activity, type II transmembrane glycoproteinKELLBelongs to peptidase family m13 (zinc metalloprotease); also known as the neprilysin subfamily
CD239Erythroid cells78A type I membrane protein.The human F8/G253 antigen, B-CAM, is a cell surface glycoprotein that is expressed with restricted distribution pattern in normal fetal and adult tissues, and is upregulated following malignant transformation in some cell types. Its overall structure is similar to that of the human tumor marker MUC 18 and the chicken neural adhesion molecule SC1B-CAM (B-cell adhesion molecule), LU, Lutheran blood group Immunoglobulin superfamily
CD240CEErythroid cells45.5Rhesus blood group, CcEe antigens. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. It is highly hydrophobic and deeply buried within the phospholipid bilayerRHCE, RH30A, RHPI, Rh4Rh family
CD240DErythroid cells45.5 (product—30)Rhesus blood group, D antigen. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Absent in the Caucasian RHD-negative phenotypeRhD, Rh4, RhPI, RhII, Rh30DRh family
CD241Erythroid cells50Rhesus blood group-associated glycoprotein RH50, component of the RH antigen multisubunit complex; required for transport and assembly of the Rh membrane complex to the red blood cell surface. highly homologous to RH, 30kD components. Defects in RhAg are a cause of a form of chronic hemolytic anemia associated with stomatocytosis, and spherocytosis, reduced osmotic fragility, and increased cation permeabilityRhAg, RH50ARh family
CD242Erythroid cells42 Intercellular adhesion molecule 4, Landsteiner-Wiener blood group. LW molecules may contribute to the vasoocclusive events associated with episodes of acute pain in sickle cell diseaseICAM-4, LW Immunoglobulin superfamily, intercellular adhesion molecules (ICAMs)
CD243 Stem/progenitor cells170Multidrug resistance protein 1 (P-glycoprotein). P-gp has been shown to utilise ATP to pump hydrophobic drugs out of cells, thus increasing their intracellular concentration and hence their toxicity. The MDR 1 gene is amplified in multidrug resistant cell linesMDR-1, p-170ABC superfamily of ATP-binding transport proteins
CD244NK cells662B4 is a cell-surface glycoprotein related to CD2 and implicated in the regulation of natural killer and T-lymphocyte function. It appears that the primary function of 2B4 is to modulate other receptorligand interactions to enhance leukocyte activation2B4, NK cell activation inducing ligand (NAIL) Immunoglobulin superfamily
CD245T cells 220–240Cyclin E/Cdk2 interacting protein p220. NPAT is involved in a key S phase event and links cyclical cyclin E/Cdk2 kinase activity to replication-dependent histone gene transcription.NPAT gene may be essential for cell maintenance and may be a member of the housekeeping genesNPAT
CD246Expressed in the small intestine, testis, and brain but not in normal lymphoid cells177 kDa; after glycosylation, produces a 200 kDa mature glycoproteinAnaplastic (CD30+ large cell) lymphoma kinase; plays an important role in brain development, involved in anaplastic nodal non Hodgkin lymphoma or Hodgkin's disease with translocation t(2;5)(p23;q35) or inv2(23;q35). Oncogenesis via the kinase function is activated by oligomerization of NPM1-ALK mediated by the NPM1 partALKInsulin receptor family of tyrosine-protein kinases
CD247T cells, NK cells16T-cell receptor ζ; has a probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. TCRζ together with TCRα:β and γ:δ heterodimers and CD3-γ, -δ, and -ε, forms the TCR-CD3 complex. The ζ chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune responseζ chain, CD3Z Immunoglobulin superfamily

Complied by Laura Herbert, Royal Free Hospital, London. Data based on CD designations made at the 7th Workshop on Human Leucocyte Differentiation Antigens, provided by Protein Reviews on the Web (http://www​.ncbi.nlm.nih.gov/prow/).

By agreement with the publisher, this book is accessible by the search feature, but cannot be browsed.

Copyright © 2001, Garland Science.
Bookshelf ID: NBK10772

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