Mls antigens

Mls antigens are non-MHC antigens that provoke strong primary mixed lymphocyte responses. They are encoded by minor lymphocyte stimulatory (Mls) loci, which are endogenous mammary tumor viruses integrated in the mouse genome. Mls antigens are encoded in the 3′ long terminal repeat of the integrated virus and act as superantigens. They stimulate a large number of T lymphocytes by binding to the Vb domain of all T-cell receptors bearing the Vb for which the superantigen is specific.