Table 72Characteristics of RCTs comparing haloperidol versus olanzapine in the treatment of bipolar disorder

Study, Design (Followup)Interventions, Dosages; No. Randomized,
Washout Period
Main Inclusion criteriaRisk of Bias,
Financial Support
Moreno et al. 2007119
RCT (6 wks)
G1: HAL (3–15mg/d); (5)
G2: OLA (5–20mg/d); (7)
Washout period: 4 d
BP; switched between depression and mania phase ≤1 mo before or after PSG procedureUnclear,
Foundation
Tohen et al. 2003140
RCT (12 wks)
G1: HAL (3–15mg/d); (219)
G2: OLA (5–20mg/d); (234)
BP defined by DSM–IVHigh,
Industry

AP(s) = antipsychotic(s); BP = bipolar disorder; D = days; DSM-IV = diagnostic and statistical manual of mental disorders; G = group; HAL = haloperidol; Hr(s) = hour(s); Mg = milligrams; Mo = month; OLA = olanzapine; PSG = polysomnographic studies; RCT = randomized controlled trial; Wk(s) = week(s);

From: Results

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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