Table 29Strength of evidence (GRADE): haloperidol versus aripiprazole

OutcomeSourceRoBConsistencyDirectnessPrecisionSoE
Positive Symptoms
PANSS2 RCTMediumConsistentDirectImpreciseLow (ND)
SAPS1 RCTMediumUnknownDirectImpreciseInsufficient
Negative Symptoms
PANSS3 RCTMediumConsistentDirectImpreciseModerate (favoring aripiprazole)
SANS1 RCTMediumUnknownDirectImpreciseInsufficient
General Psychopathology
ACES1 RCTMediumUnknownDirectImpreciseInsufficient
CABS1 RCTMediumUnknownDirectImpreciseInsufficient
PANSS1 RCTMediumUnknownDirectImpreciseInsufficient
Global Ratings and Total Scores
BPRS3 RCTMediumConsistentDirectImpreciseLow (ND)
CGI–I1 RCTMediumUnknownDirectImpreciseInsufficient
CGI–S5 RCTMediumConsistentDirectImpreciseLow (ND)

ACES = Agitation-Calmness Evaluation Scale; BPRS = Brief Psychiatric Rating Scale; CABS = Corrigan Agitated Behavior Scale; CGI–S = Clinical Global Impression–Severity; PANSS = Positive and Negative Symptom Scale; RCT = randomized controlled trial; RoB = risk of bias; SANS = Scale for the Assessment of Negative Symptoms; SAPS = Scale for the Assessment of Positive Symptoms; SoE = Strength of Evidence; ND = no difference

From: Results

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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