Figure 20 is a metagraph depicting the effect of haloperidol versus quetiapine on global ratings and total scores in patients with Sz. Four trials (n=756) reported no difference on the BPRS (MD=1.23, 95 percent CI, −0.50, 2.96). Three trials (n=623) showed no significant difference using the CGI-I (MD=0.02, 95 percent CI −0.24, 0.27). Four trials (n=1,253) demonstrated a significant difference favoring haloperidol when the results were pooled for the CGI-S score (MD=−0.23, 95 percent CI, −0.42, −0.04). Six trials (n=1,048) used the PANSS scale to evaluate the total scores and reported no significant difference between groups (MD=1.18, 95 percent CI, −0.94, 3.31).

Figure 20Haloperidol versus quetiapine – Global ratings and total scores

BPRS = Brief Psychiatric Rating Scale; CGI–I = Clinical Global Impression–Improvement; CGI–S = Clinical Global Impression–Severity; CI = confidence intervals; df = degrees of freedom; I2 = I-squared; IV = inverse variance; PANSS = Positive and Negative Symptom Scale; SD = standard deviation

From: Results

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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