Table 65Patient flow through trials–haloperidol versus clozapine

Intervention #1Intervention #2Intervention #3Intervention #4Intervention #5Intervention #6
Breier et al. 199455ClassificationFGASGA
MedicationHaloperidolClozapine
Dosage10–30mg/d200–600mg/d
No screened:NR
No randomized:NRNR
No completed:2019
No analyzed (E):2019
No analyzed (S):2019
Citrome et al. 200162ClassificationFGASGASGASGA
MedicationHaloperidolClozapineOlanzapineRisperidone
Dosage10–30mg/d200–800mg/d10–40mg/d4–16mg/d
No screened:NR
No randomized:37403941
No completed:27323028
No analyzed (E):37403941
No analyzed (S):37403941
Covington et al. 200070ClassificationFGASGA
MedicationHaloperidolClozapine
DosageNRNR
Patient flow through trial
No screened:NR
No randomized:4240
No completed:NRNR
No analyzed (E):4240
No analyzed (S):4240
Itoh et al. 1977155ClassificationFGASGA
MedicationHaloperidolClozapine
Dosage2.25–15mg/d75–500mg/d
No screened:NR
No randomized:4147
No completed:NRNR
No analyzed (E):NRNR
No analyzed (S):NRNR
Kane et al. 200195ClassificationFGASGA
MedicationHaloperidolClozapine
Dosage5–16mg/d12.5–800mg/d
No screened:NR
No randomized:3437
No completed:1224
No analyzed (E):1123
No analyzed (S):3437
Kleiser et al. 1994103ClassificationFGASGA
MedicationHaloperidolClozapine
Dosage16mg/d350mg/d
No screened:NR
No randomized:1818
No completed:1717
No analyzed (E):1717
No analyzed (S):1717
Krakowski et al. 2006105ClassificationFGASGASGA
MedicationHaloperidolClozapineOlanzapine
Dosage10–30mg/d200–800mg/d10–35mg/d
No screened:134
No randomized:363737
No completed:202426
No analyzed (E):363737
No analyzed (S):363737
Rosenheck et al. 1997126ClassificationFGASGA
MedicationHaloperidolClozapine
Dosage5–30mg/d100–900mg/d
No screened:423
No randomized:218205
No completed:61117
No analyzed (E):218205
No analyzed (S):218205
Volakva et al. 2002145ClassificationFGASGASGASGA
MedicationHaloperidolClozapineOlanzapineRisperidone
Dosage10–30mg/d200–800mg/d10–40mg/d4–16mg/d
No screened:NR
No randomized:37403941
No completed:21222622
No analyzed (E):37403941
No analyzed (S):37403941

d = day; E = efficacy; FGA = first-generation antipsychotic; mg = milligram; No = number; NR = not reported; S = safety; SGA = second-generation antipsychotic

From: Appendix I, Patient Flow Through Trials

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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