Funnel plot 7 is a scatterplot that explores potential publication bias for studies comparing haloperidol versus risperidone for core symptoms and positive score on the PANSS scale. The mean difference is plotted along the X-axis and standard error is plotted along the Y-axis. The point estimate of the PANSS scale for each study is represented by a square dot. A broken line, which represents the point estimate of the meta-analysis is positioned at 0.64 on the mean difference scale. Tests for publication bias were not significant, although the funnel plot shows some asymmetry due to the two small studies that showed large effects for risperidone.

Funnel plot 7Haloperidol versus risperidone–Core symptoms (Sz)–positive score–PANSS (positive) scale

PANSS = Positive and Negative Syndrome Scale; MD = Mean Difference; SE = Standard Error; Sz = schizophrenia

Begg and Mazumdar rank correlation: p = 0.63; Egger’s regression intercept: p = 0.11

From: Appendix K, Funnel Plots

Cover of First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness
First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness [Internet].
Comparative Effectiveness Reviews, No. 63.
Abou-Setta AM, Mousavi SS, Spooner C, et al.

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