NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

Cover of Drug Class Review: Hormone Therapy for Postmenopausal Women or Women in the Menopausal Transition Stage

Drug Class Review: Hormone Therapy for Postmenopausal Women or Women in the Menopausal Transition Stage

Final Report Update # 3

Drug Class Reviews

, MD, MPH, , MA, , MPH, and , MS.

Oregon Evidence-based Practice Center, Oregon Health & Science University, Mark Helfand, MD, MPH, Director
Portland, (OR): Oregon Health & Science University; .

Estrogen was approved as a hormone supplement in the 1940's to treat estrogen withdrawal symptoms in menopausal women. Estrogen production declines in women when ovarian function changes with aging or after surgical removal of the ovaries. This drop in estrogen levels can trigger a vasomotor response resulting in a sensation of flushing and sweating that interferes with function and sleep (hot flashes or flushes). Studies conducted in recent years have identified additional health benefits of postmenopausal estrogen besides symptom management (osteoporosis) as well as potential harms (cardiovascular disease, breast cancer, and cholecystitis). The purpose of this review was to compare the efficacy and adverse effects of different estrogens.

Contents

Update #3 Conducted by Susan L. Norris, MD, MPH, Susan Carson, MPH

The funding source, the Center for Evidence-based Policy, is supported by 17 organizations, including 15 state Medicaid programs. These organizations selected the topic and had input into the Key Questions for this review. The content and conclusions of the review are entirely determined by the Evidence-based Practice Center researchers. The authors of this report have no financial interest in any company that makes or distributes the products reviewed in this report.

Suggested citation:

Nelson HD, Nygren P, Freeman M, Chan BKS. Drug Class Review on Hormone Therapy. 2007. http://www.ohsu.edu/drugeffectiveness/reports/final.cfm

The purpose of this report is to make available information regarding the comparative effectiveness and safety profiles of different drugs within pharmaceutical classes. Reports are not usage guidelines, nor should they be read as an endorsement of, or recommendation for, any particular drug, use or approach. Oregon Health & Science University does not recommend or endorse any guideline or recommendation developed by users of these reports.

Copyright © 2007, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK10537PMID: 20496442

Views

  • PubReader
  • Print View
  • Cite this Page
  • PDF version of this title (984K)

Other titles in this collection

Related information

Similar articles in PubMed

See reviews...See all...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...