Table 4Drugs for constipation: product information and directions for administration

Generic NameDosage FormStrengthFrequencyOnset of ActionUsual Daily DoseDirections
Docusate calciumCapsules240 mg/capsuleOnce daily12–72 hours240 mgTake with water
Docusate sodiumTablets100mg/tab.One to three times a day12–72 hoursAdults: Up to 300 mgTake with a glass of water

Syrup/liquid may be mixed with milk or juice
Capsules50mg/capsuleChildren: Up to 100 mg
100mg/capsule
Soft gels50mg/gel
100mg/gel
250mg/gel
Syrup20mg/5ml
50mg/15ml
60mg/15ml
100mg/30ml
Liquid10mg/ml
150mg/ml
LactuloseSolution10g/15mlOnce daily (twice daily if needed)24–48 hoursAdults: 20–30 gDissolve in 120ml water
Crystals10g/packet
20g/packet
Children: 5g
LubiprostoneSoft gelatin capsules24mcg/capsuleTwice dailyWithin 24 hours48 mcgTake with food
Polyethylene glycol 3350Powder packets17g/packetOnce daily48–96 hours17 gDissolve in 8oz water
Powder17g/capful17 g
PsylliumCapsules0.52g/capsuleThree times a day12–72 hoursAdults: 10.2–18 gTake capsules with 8oz water

Dissolve powder in 8oz water

Mix granules with 8oz water or sprinkle on cereal or food
Powder3.4g/tspChildren: ½ adult dose
6g/tsp
Granules4.03g/tsp
2.5g/tsp
Wafers3.4g/wafer
Tegaserod*Tablets6mg/tabletTwice dailyWithin the first week12 mgTake 30 min. before meals
2mg/tablet

* Marketing suspended March, 2007 because of increased risk of serious cardiovascular events

From: Introduction

Cover of Drug Class Review: Constipation Drugs
Drug Class Review: Constipation Drugs: Final Report [Internet].
Gartlehner G, Jonas DE, Morgan LC, et al.
Portland (OR): Oregon Health & Science University; 2007 Sep.
Copyright © 2007, Oregon Health & Science University, Portland, Oregon.

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