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McDonagh M, Peterson K, Lee N, et al. Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet]. Portland (OR): Oregon Health & Science University; 2008 Oct.

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Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet].

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Appendix CSearch strategy and update history

Search StrategyiOriginal Report

Cochrane Databases

First drug list

#1. (gabapentin or Neurontin or Depakote or (valproic next acid) or carbamazepine or Tegretol or lamotrigine or Lamictal or oxcarbazepine or Trileptal) 1880

#2. (zonisamide or Zonegran) 37

#3. (#1 or #2) 1899

#4. (#3 or anticonvulsive* or anti-convulsive* or antiepileptic* or anti-epileptic* or anticonvulsant* or anti-convulsant*) 2807

#5. (#4 and (bipolar or mood or antimanic or manic or depressive or depression or pain or neuralgi* or migraine*)) 748

Second drug list

#1. (levetiracetam or Keppra or phenytoin or Dilantin or tiagabine or Gabitril or topiramate or Topamax) 1117

#2. (depression or depressive or mood or bipolar or manic or antimanic or anti-manic or mania or antimania or anti-mania) 21439

#3. (pain or neuralgi* or headache) 35985

#4. (#1 and (#2 or #3)) 207

PubMed

First and second drug lists

#1 Search gabapentin OR Neurontin OR Depakote OR "valproic acid" OR carbamazepine OR Tegretol OR lamotrigine OR Lamictal OR oxcarbazepine OR Trileptal OR zonisamide OR Zonegran OR anticonvulsive* OR anti-convulsive* OR antiepileptic* OR anti-epileptic* Limits: English 18449

#2 Search #1 OR anticonvulsants Limits: English 89165

#3 Search levetiracetam OR Keppra OR phenytoin OR Dilantin OR tiagabine OR Gabitril OR topiramate OR Topamax Limits: English 12654

#4 Search #2 OR #3 Limits: English 90068

#5 Search depressive disorders OR bipolar disorder OR mood disorders OR mood OR antimanic OR manic OR depressive OR depression OR pain OR neuralgi* OR migraine* Limits: English 380912

#6 Search #4 AND #5 Field: All Fields, Limits: English, Human 6863

#7 Search #6 AND (randomi* OR randomized clinical trials OR randomized controlled trial[pt] OR meta analys* OR meta analysis OR meta analysis[pt] OR systematic review) Field: All Fields, Limits: English, Human 1472

Adverse events

#1 Search epidemiol* OR pharmacoepidemiolog* Limits: English, Human 479331

#2 Search observational OR prescription database evaluation* OR patient database evaluation* OR prescription event monitor* Limits: English, Human 13177

#3 Search spontaneous adverse drug reaction report OR Phase iv OR postmarketing surveillance OR cohort studies OR long-term OR odds ratio OR relative risk OR case-control Limits: English, Human 785214

#4 Search antiepileptic drug*/adverse effects Limits: English, Human 1423

#5 Search #1 AND (#2 OR #3) AND #4 Limits: English, Human 87

#6 Search anticonvulsants/adverse effects Limits: English, Human 4379

#7 Search #1 AND (#2 OR #3) AND #6 Limits: English, Human 179

#8 Search #7 NOT #6 Limits: English, Human 106 TOTAL NUMBER OF HITS: 193

Embase

First drug list

1 47396 gabapentin or Neurontin or Depakote or carbamazepine or Tegretol or lamotrigine

2 48119 s1 or Lamictal or oxcarbazepine or Trileptal or zonisamide or Zonegran

3 197580 anticonvulsive agent!

4 43131 anticonvulsive? or anti(2w)convulsive? or antiepileptic? or anti(2w)epileptic?

5 200384 1−4/+

6 265510 depression! or depression/ti,ab or depressive or mood disorder! or mood?(2n)disorder? or bipolar disorder! or bipolar/ti,ab

7 265610 s6 or manic depressive psychosis or antimanic or anti(2w)manic or antimania or anti(2w)mania

8 376100 pain! or neuralgia! or migraine or headache(2w)facial()pain

9 265610 6+7

10 3906 4*9

11 4995 4*8

12 327396 randomi?/ti,ab or randomized controlled trial? or systematic()review? or metaanaly? or meta(2w)analy?

13 373 10*12

14 531 11*12

15 775 13+14

16 392 rd (unique items)

Second drug list

s1 35686 levetiracetam or Keppra or phenytoin or Dilantin or tiagabine or Gabitril or topiramate or Topamax

s2 172309 depression! or depression/ti,ab or depressive or mood disorder! or mood?(2n)disorder? or bipolar disorder! or bipolar/ti,ab

s3 172388 s2 or manic depressive psychosis or antimanic or anti(2w)manic or antimania or anti(2w)mania

s4 227193 pain! or neuralgia! or migraine or headache(2w)facial()pain

s5 4086 1*(3+4)

s6 321 s5 and (randomi?/ti,ab or randomized controlled trial? or systematic()review? or metaanaly? or meta(2w)analy?)

s7 307 s6/eng

s8 307 s7/human

s9 15950 anticonvulsant? or anti(2w)convulsant?

s10 1853 9*(3+4)

s11 154 s10 and (randomi?/ti,ab or randomized controlled trial? or systematic()review? or metaanaly? or meta(2w)analy?)

s12 143 s11/eng

s13 70 12-7

Adverse events

s1 146691 anticonvulsive agent! or anticonvulsive therapy or anticonvuls?/ti,ab or anti(2w)convuls?/ti,ab or antiepileptic?/ti,ab or anti(2w)epileptic?/ti,ab

s2 56365 s1 and (adverse drug reaction! or side(2w)effect? or toxic? or drug response or adverse(2w)effect? or adverse(2w)event?)

s3 2518 anticonvulsant therapy/ae

s4 1169 s3 and (adverse drug reaction! or side(2w)effect? or toxic? or drug response or adverse(2w)effect? or adverse(2w)event?)

s5 56386 2+4

s6 4068 s5 and (epidemiol? or pharmacoepidemiolog?)

s7 43 s6 and (observational or prescription()database()evaluation? or patient()database()evaluation? or prescription()event() monitor? or spontaneous()adverse()drug()reaction()report?)

s8 467 s6 and (phase()iv or phase()4 or phase()four or postmarketing()surveillance or cohort? or long(2w)term or odds()ratio or relative()risk or case(2w)control)

s9 498 7+8

s10 452 s9/eng

s11 449 s10/human

Search Strategy: Update 1

Search #1 (Original drugs + original diagnoses)

PubMed (2004–2005)

Other limiters

English

Human

Search strategy

gabapentin OR Neurontin OR Depakote OR "valproic acid" OR carbamazepine OR Tegretol OR lamotrigine OR Lamictal OR oxcarbazepine OR Trileptal OR zonisamide OR Zonegran OR anticonvulsive* OR anticonvulsants OR anti-convulsive* OR antiepileptic* OR anti-epileptic* OR levetiracetam OR Keppra OR phenytoin OR Dilantin OR tiagabine OR Gabitril OR topiramate OR Topamax

AND

depressive disorders OR bipolar disorder OR mood disorders OR mood OR antimanic OR manic OR depressive OR depression OR pain OR neuralgi* OR migraine*

AND

randomi* OR randomized clinical trials OR randomized controlled trial[pt] OR meta analys* OR meta analysis OR meta analysis[pt] OR systematic review)

Number of items retrieved: 356

SEARCH #2 (Fibromyalgia + original and new drugs)

PubMed (1966–2005)

Other limiters

English

Human

Search strategy

fibromyalgia OR fibrositis

AND

gabapentin OR Neurontin OR Depakote OR "valproic acid" OR carbamazepine OR Tegretol OR lamotrigine OR Lamictal OR oxcarbazepine OR Trileptal OR zonisamide OR Zonegran OR anticonvulsive* OR anticonvulsants OR anti-convulsive* OR antiepileptic* OR anti-epileptic* OR levetiracetam OR Keppra OR phenytoin OR Dilantin OR tiagabine OR Gabitril OR topiramate OR Topamax OR pregabalin OR 3-isobutyl gaba OR Lyrica OR ethotoin OR Peganone

Number of items retrieved: 29

SEARCH #3 (New drugs + original diagnoses)

PubMed (1966–2005)

Other limiters

English

Human

Search strategy

pregabalin OR 3-isobutyl gaba OR Lyrica OR ethotoin OR Peganone

AND

depressive disorders OR bipolar disorder OR mood disorders OR mood OR antimanic OR manic OR depressive OR depression OR pain OR neuralgi* OR migraine*

Number of items retrieved: 17

SEARCH #4 (Original drugs + original diagnoses)

Embase (2004–2005)

Other limiters

English

Human

Search strategy:

levetiracetam or Keppra or phenytoin or Dilantin or tiagabine or Gabitril or topiramate or Topamax or gabapentin or Neurontin or Depakote or valproic acid or carbamazepine or Tegretol or lamotrigine or Lamictal or oxcarbazepine or Trileptal or zonisamide or Zonegran or anticonvulsive? or anticonvulsant? or anti(2w)convulsive? or anti(2w)convulsant? or antiepileptic? or anti(2w)epileptic?

AND

depression! or depression/ti,ab or depressive or mood disorder! or mood?(2n)disorder? or bipolar disorder! or bipolar/ti,ab or manic depressive psychosis or antimanic or anti(2w)manic or antimania or anti(2w)mania or pain! or neuralgia! or migraine or headache(2w)facial()pain

AND

(randomi?/ti,ab or randomized controlled trial? or systematic()review? or metaanaly? or meta(2w)analy?)

Number of items retrieved: 640

SEARCH #5 (Original and new drugs + fibromyalgia)

Embase (1974–2005)

Other limiters:

English

Human

Search strategy:

levetiracetam or Keppra or phenytoin or Dilantin or tiagabine or Gabitril or topiramate or Topamax or gabapentin or Neurontin or Depakote or valproic acid or carbamazepine or Tegretol or lamotrigine or Lamictal or oxcarbazepine or Trileptal or zonisamide or Zonegran or anticonvulsive? or anticonvulsant? or anti(2w)convulsive? or anti(2w)convulsant? or antiepileptic? or anti(2w)epileptic? OR pregabalin OR 3-isobutyl gaba OR Lyrica OR ethotoin OR Peganone

AND

fibromyalgia or fibrositis

NOT

results of Search #4

Number of items retrieved: 175

SEARCH #6 (New drugs + original diagnoses)

Embase (1974–2005)

Other limiters

English

Human

Search strategy

pregabalin OR 3-isobutyl gaba OR Lyrica OR ethotoin OR Peganone

AND

depression! or depression/ti,ab or depressive or mood disorder! or mood?(2n)disorder? or bipolar disorder! or bipolar/ti,ab or manic depressive psychosis or antimanic or anti(2w)manic or antimania or anti(2w)mania or pain! or neuralgia! or migraine or headache(2w)facial()pain

NOT

results of Searches #4 OR #5

Number of items retrieved: 269

SEARCH #7 (Original drugs + original diagnoses)

Cochrane (2004–2005)

Search strategy

gabapentin OR Neurontin OR Depakote OR "valproic acid" OR carbamazepine OR Tegretol OR lamotrigine OR Lamictal OR oxcarbazepine OR Trileptal OR zonisamide OR Zonegran OR anticonvulsive* OR anticonvulsants OR anti-convulsive* OR antiepileptic* OR anti-epileptic* in All Fields or levetiracetam OR Keppra OR phenytoin OR Dilantin OR tiagabine OR Gabitril OR topiramate OR Topamax

AND

depressive disorders OR bipolar disorder OR mood disorders OR mood OR antimanic OR manic OR depressive OR depression OR pain OR neuralgi* OR migraine*

Number of items retrieved: 136

SEARCH #8 (New drugs + original diagnoses)

Cochrane (1966–2005)

Search strategy

pregabalin OR 3-isobutyl gaba OR Lyrica OR ethotoin OR Peganone

AND

depressive disorders OR bipolar disorder OR mood disorders OR mood OR antimanic OR manic OR depressive OR depression OR pain OR neuralgi* OR migraine*

Number of items retrieved: 2

SEARCH #9 (New drugs + new diagnosis)

Cochrane (1966–2005)

Search strategy:

pregabalin OR 3-isobutyl gaba OR Lyrica OR ethotoin OR Peganone

AND

fibromyalgia OR fibrositis

Number of items retrieved: 4

ADVERSE EVENTS SEARCH

PubMed (April 2004–2005)

Other limiters

English

Human

Search strategy

epidemiol* OR pharmacoepidemiolog*

AND

observational OR prescription database evaluation* OR patient database evaluation* OR prescription event monitor* OR spontaneous adverse drug reaction report* OR Phase iv OR postmarketing surveillance OR cohort studies OR long-term OR odds ratio OR relative risk OR case-control

AND

antiepileptic drug*/adverse effects OR anticonvulsants/adverse effects

Number of items retrieved: 26

Cochrane Database of Systematic Reviews, DARE, Controlled Trials Register via OVID (2004–2005)

Search strategy

(antiepileptic$ OR anti epileptic$ OR anticonvuls$ OR anti convuls$).mp.

AND

adverse.mp.

AND

epidemiol$.mp. OR pharmacoepidemiolog$.mp.

AND

(spontaneous adverse drug reaction OR Phase iv OR postmarketing surveillance OR cohort OR long-term OR odds ratio OR relative risk OR case-control OR observational OR prescription database evaluation$ OR patient database evaluation$ OR prescription event monitor$).mp.

Number of items retrieved: 26

Embase (2004–2005)

Other limiters

English

Human

Search strategy

[anticonvulsive agent! OR anticonvulsive therapy OR anticonvuls?/ti,ab OR anti(2w)convuls?/ti,ab OR antiepileptic?/ti,ab

AND

adverse drug reaction! OR side(2w)effect? OR toxic? OR drug response OR adverse(2w)effect? OR adverse(2w)event?] OR anticonvulsant therapy/ae

AND

epidemiol? OR pharmacoepidemiolog?

AND

observational OR prescription()database()evaluation? OR patient()database()evaluation?

OR prescription()event()monitor? OR spontaneous()adverse()drug()reaction()report?

OR phase()iv or phase()4 OR phase()four OR postmarketing()surveillance OR cohort?

OR long(2w)term OR odds()ratio OR relative()risk OR case(2w)control

Number of items retrieved: 125

Search Strategy: Update 2

Database: Ovid MEDLINE(R) <1950 to March Week 1 2008>
Search Strategy:
1exp Bipolar Disorder/dt [Drug Therapy] (8112)
2carbamazepine.mp. or exp Carbamazepine/(10771)
3tegretol.mp. (328)
4divalproex.mp. or exp Valproic Acid/(7679)
5valproic acid.mp. (8616)
6depakote.mp. (39)
7ethotoin.mp. (33)
8peganone.mp. (12)
9gabapentin.mp. (2513)
10neurontin.mp. (96)
11lamotrigine.mp. (2491)
12lamictal.mp. (51)
13levetiracetam.mp. (726)
14keppra.mp. (53)
15oxcarbazepine.mp. (833)
16trileptal.mp. (27)
17phenytoin.mp. or exp Phenytoin/(14459)
18dilantin.mp. (447)
19pregabalin.mp. (401)
20lyrica.mp. (19)
21tiagabine.mp. (655)
22gabitril.mp. (18)
23topiramate.mp. (1818)
24topamax.mp. (45)
25depakene.mp. (34)
26depacon.mp. (10)
27zonisamide.mp. (593)
28zonegran.mp. (11)
292 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 or 28 (34217)
301 and 29 (1616)
31limit 30 to (English language and humans and yr="1966 – 2008" and "all adult (19 plus years)" and (clinical trial, all or comparative study or controlled clinical trial or evaluation studies or meta analysis or multicenter study or randomized controlled trial)) (320)
32from 31 keep 1–320 (320)
Database: PsycINFO <1806 to March Week 2 2008>
Search Strategy:
1carbamazepine.mp. or exp Carbamazepine/(2272)
2tegretol.mp. (44)
3divalproex.mp. or exp Valproic Acid/(1247)
4valproic acid.mp. (1188)
5depakote.mp. (15)
6ethotoin.mp. (4)
7peganone.mp. (0)
8gabapentin.mp. (559)
9neurontin.mp. (13)
10lamotrigine.mp. (794)
11lamictal.mp. (7)
12levetiracetam.mp. (210)
13keppra.mp. (11)
14oxcarbazepine.mp. (231)
15trileptal.mp. (4)
16phenytoin.mp. or exp Phenytoin/(691)
17dilantin.mp. (79)
18pregabalin.mp. (88)
19lyrica.mp. (5)
20tiagabine.mp. (155)
21gabitril.mp. (2)
22topiramate.mp. (618)
23topamax.mp. (5)
24depakene.mp. (5)
25depacon.mp. (1)
26zonisamide.mp. (104)
27zonegran.mp. (3)
281 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 (5546)
29Bipolar Disorder.mp. or exp Bipolar Disorder/(14161)
3028 and 29 (1410)
31limit 30 to (human and English language and ("0400 empirical study" or "0430 followup study" or "0450 longitudinal study" or "0451 prospective study" or "0452 retrospective study" or "0800 literature review" or "0830 systematic review" or 1200 meta analysis or 1800 quantitative study or "2000treatment outcome/randomized clinical trial") and adulthood <18+ years> and yr="1966 – 2008") (649)
32from 31 keep 1–649 (649)
Database: EBM Reviews - Cochrane Central Register of Controlled Trials <1st Quarter 2008>
Search Strategy:
1carbamazepine.mp. or exp Carbamazepine/(1138)
2tegretol.mp. (74)
3divalproex.mp. or exp Valproic Acid/(549)
4valproic acid.mp. (629)
5depakote.mp. (26)
6ethotoin.mp. (2)
7peganone.mp. (0)
8gabapentin.mp. (365)
9neurontin.mp. (35)
10lamotrigine.mp. (447)
11lamictal.mp. (49)
12levetiracetam.mp. (106)
13keppra.mp. (10)
14oxcarbazepine.mp. (158)
15trileptal.mp. (11)
16phenytoin.mp. or exp Phenytoin/(798)
17dilantin.mp. (29)
18pregabalin.mp. (83)
19lyrica.mp. (0)
20tiagabine.mp. (118)
21gabitril.mp. (7)
22topiramate.mp. (322)
23topamax.mp. (1)
24depakene.mp. (6)
25depacon.mp. (4)
26zonisamide.mp. (48)
27zonegran.mp. (4)
281 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 (3470)
29Bipolar Disorder.mp. or exp Bipolar Disorder/(1646)
3028 and 29 (335)
31limit 30 to ((clinical trial or comparative study or controlled clinical trial or meta analysis or multicenter study or randomized controlled trial) and yr="1966 – 2007") (192)
32from 31 keep 1–192 (192)
Database: EBM Reviews - Cochrane Database of Systematic Reviews <1st Quarter 2008>
Search Strategy:
1carbamazepine.mp. or exp Carbamazepine/(90)
2tegretol.mp. (4)
3divalproex.mp. or exp Valproic Acid/(16)
4valproic acid.mp. (28)
5depakote.mp. (3)
6ethotoin.mp. (1)
7peganone.mp. (0)
8gabapentin.mp. (51)
9neurontin.mp. (0)
10lamotrigine.mp. (39)
11lamictal.mp. (2)
12levetiracetam.mp. (12)
13keppra.mp. (0)
14oxcarbazepine.mp. (21)
15trileptal.mp. (4)
16phenytoin.mp. or exp Phenytoin/(62)
17dilantin.mp. (1)
18pregabalin.mp. (12)
19lyrica.mp. (0)
20tiagabine.mp. (19)
21gabitril.mp. (2)
22topiramate.mp. (28)
23topamax.mp. (1)
24depakene.mp. (4)
25depacon.mp. (2)
26zonisamide.mp. (16)
27zonegran.mp. (0)
281 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 (146)
29Bipolar Disorder.mp. or exp Bipolar Disorder/(69)
3028 and 29 (21)
31from 30 keep 1–21 (21)
Database: Ovid MEDLINE(R) <1996 to May Week 4 2008>
Search Strategy:
1exp Anticonvulsants/ae, po, to [Adverse Effects, Poisoning, Toxicity] (7185)
2exp Clinical Trials, Phase IV as Topic/or phase iv.mp. (758)
3exp Case-Control Studies/or case control.mp. (289134)
4exp Cohort Studies/or cohort.mp. (434363)
5long term.mp. (202223)
6exp Product Surveillance, Postmarketing/(5332)
7((postmarket$ or post-market$) adj5 (surveill$ or monitor$)).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (2964)
8((prescri$ or patient$) adj5 (database$ adj3 evaluat$)).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (50)
9exp Drug Monitoring/(7153)
10observational.mp. (25729)
11(prescri$ adj5 monitor$).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (658)
12(adverse drug reaction$ adj5 report$).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (3256)
132 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 (818199)
141 and 13 (1616)
15(epidemiol$ or pharmacoepidem$ or pharmacovigil$).mp. [mp=title, original title, abstract, name of substance word, subject heading word] (115772)
16(ep or eh or mo).fs. (582353)
1715 or 16 (633513)
1814 and 17 (299)
19(2005$ or 2006$ or 2007$ or 2008$).ed. (2190369)
2018 and 19 (129)
21from 20 keep 1–129 (129)
Database: Ovid MEDLINE(R) <1996 to June Week 1 2008>
Search Strategy:
1"147".fc_vol. and "Chou$".fc_auts. and "2007".fc_pubyr. and "505".fc_pg. (1)
2*"Low Back Pain"/(5566)
3"22".fc_vol. and "Muehlbacher$".fc_auts. and "2006".fc_pubyr. and "526".fc_pg. (1)
4"Chronic Disease"/(72695)
5low back pain {No Related Terms} (870)
6pain {No Related Terms} (565)
7chronic pain {No Related Terms} (517)
8pain.sh. (41969)
9pain/or back pain/or facial pain/or neck pain/or pain, intractable/or pain, referred/(51006)
10carbamazepine.mp. or exp Carbamazepine/(5064)
11divalproex.mp. or exp Valproic Acid/(3954)
12ethotoin.mp. (2)
13gabapentin.mp. (2394)
14lamotrigine.mp. (2242)
15levetiracetam.mp. (739)
16oxcarbazepine.mp. (704)
17phenytoin.mp. or exp Phenytoin/(3439)
18pregabalin.mp. (414)
19tiagabine.mp. (590)
20topiramate.mp. (1801)
21valproic acid.mp. or exp Valproic Acid/(4537)
22zonisamide.mp. (496)
2310 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 (15804)
249 and 23 (589)
25limit 24 to (English language and humans) (400)
26from 25 keep 11–20 (10)
27from 25 keep 1–400 (400)
Database: EBM Reviews - Cochrane Central Register of Controlled Trials <2nd Quarter 2008>
Search Strategy:
1carbamazepine.mp. or exp Carbamazepine/(1145)
2tegretol.mp. (74)
3divalproex.mp. or exp Valproic acid/(560)
4valproic acid.mp. (638)
5depakote.mp. (28)
6ethotoin.mp. (2)
7peganone.mp. (0)
8gabapentin.mp. (380)
9neurontin.mp. (43)
10lamotrigine.mp. (458)
11lamictal.mp. (51)
12levetiracetam.mp. (123)
13keppra.mp. (10)
14oxcarbazepine.mp. (159)
15trileptal.mp. (14)
16phenytoin.mp. or exp Phenytoin/(802)
17dilantin.mp. (29)
18pregabalin.mp. (92)
19lyrica.mp. (2)
20tiagabine.mp. (118)
21gabitril.mp. (7)
22topiramate.mp. (336)
23depakene.mp. (7)
24depacon.mp. (4)
25zonisamide.mp. (50)
26zonegran.mp. (4)
271 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 (3540)
28fibromyalgia.mp. or exp Fibromyalgia/(449)
29fibrositis.mp. (29)
3028 or 29 (460)
3127 and 30 (6)
32limit 31 to yr="2005 – 2008" (5)
33from 32 keep 1–5 (5)
Database: EBM Reviews - Cochrane Database of Systematic Reviews <2nd Quarter 2008>
Search Strategy:
1carbamazepine.mp. or exp Carbamazepine/(95)
2tegretol.mp. (4)
3divalproex.mp. or exp Valproic acid/(17)
4valproic acid.mp. (29)
5depakote.mp. (3)
6ethotoin.mp. (1)
7peganone.mp. (0)
8gabapentin.mp. (54)
9neurontin.mp. (0)
10lamotrigine.mp. (42)
11lamictal.mp. (2)
12levetiracetam.mp. (12)
13keppra.mp. (0)
14oxcarbazepine.mp. (22)
15trileptal.mp. (4)
16phenytoin.mp. or exp Phenytoin/(66)
17dilantin.mp. (1)
18pregabalin.mp. (16)
19lyrica.mp. (1)
20tiagabine.mp. (20)
21gabitril.mp. (2)
22topiramate.mp. (29)
23depakene.mp. (4)
24depacon.mp. (2)
25zonisamide.mp. (17)
26zonegran.mp. (0)
271 or 2 or 3 or 4 or 5 or 6 or 7 or 8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 (154)
28fibromyalgia.mp. or exp Fibromyalgia/(24)
29fibrositis.mp. (1)
3028 or 29 (24)
3127 and 30 (4)
32limit 31 to yr="2005 – 2008" (4)
33from 32 keep 1–4 (4)
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.
Bookshelf ID: NBK10374

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