Table 2

Adverse events analysis at patient level, mood: Antiepileptic drug compared with placebo

PlaceboIntervention Groups
Adverse EventsDrugNo. of studiesNo. of patients with eventSample sizeNo. of patients with eventSample sizePooled OR95% CI
DiarrheaCarbamazepine0NRNRNRNRNCNC
DiarrheaDivalproex2512894651871.25(0.71 to 2.24)
DiarrheaGabapentin13117599581.36(0.41 to 4.66)
DiarrheaLamotrigine32, 47, 118326255213570.53(0.28 to 1.02)
HeadacheCarbamazepine116125103231010.92(0.46 to 1.85)
HeadacheDivalproex0NRNRNRNRNCNC
HeadacheGabapentin4617596580.86(0.22 to 3.21)
HeadacheLamotrigine32, 42, 47, 1184623432207731.59(1.14 to 2.25)
NauseaCarbamazepine116, 117215220582235.16(2.73 to 10.30)
NauseaDivalproex2512994791871.64(0.94 to 2.89)
NauseaGabapentin0NRNRNRNRNCNC
NauseaLamotrigine32, 118221190322281.23(0.66 to 2.35)
RashCarbamazepine1171311761221.96(0.41 to 12.40)
RashDivalproex0NRNRNRNRNCNC
RashGabapentin0NRNRNRNRNCNC
RashLamotrigine42, 11829153635452.23(1.06 to 5.28)
SomnolenceCarbamazepine116, 117219220432232.77(1.48 to 5.36)
SomnolenceDivalproex0NRNRNRNRNCNC
SomnolenceGabapentin46175914582.35(0.80 to 7.51)
SomnolenceLamotrigine32, 118, 132321255273570.93(0.49 to 1.79)
TremorCarbamazepine0NRNRNRNRNCNC
TremorDivalproex2511294771874.76(2.38 to 10.26)
TremorGabapentin0NRNRNRNRNCNC
TremorLamotrigine471612191691.08(0.33 to 3.79)
Weight gainCarbamazepine0NRNRNRNRNCNC
Weight gainDivalproex251794391873.26(1.36 to 9.03)
Weight gainGabapentin0NRNRNRNRNCNC
Weight gainLamotrigine0NRNRNRNRNCNC

Abbreviations: CI, confidence interval; NC, not calculable; NR, not reported; OR, odds ratio (odds of antiepileptic drug / odds of placebo)

From: Appendix E, Meta-analysis of specific adverse events associated with antiepileptic drugs in the treatment of bipolar disorder

Cover of Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy
Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet].
McDonagh M, Peterson K, Lee N, et al.
Portland (OR): Oregon Health & Science University; 2008 Oct.
Copyright © 2008, Oregon Health & Science University, Portland, Oregon.

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