Table 5Mean incidence of specific adverse events in placebo-controlled trials

DrugNumber of StudiesDiarrhea
Mean (95% CI)
Vomiting
Mean (95% CI)
Anorexia
Mean (95% CI)
Dizziness
Mean (95% CI)
Donepezil1010.5% (6.6 to 14.3)7.1% (3.4 to 10.9)5.2% (2.9 to 7.6)7.2% (5.4 to 8.9)
Galantamine59.4% (1.8 to 9.4)13.0% (2.5 to 23.5)10.8% (3.6 to 17.9)11.9% (4.2 to 19.6)
Rivastigmine2NR19% (0 to 44.4)*11.2% (0 to 46.2)*17.2% (0 to 45.8)*
Tacrine48.6% (0 to 19.3)*20.6% (0 to 43.7)*NR10.2% (0 to 22.6)*
Memantine27.3% (0 to 42.2)NRNRNR

*negative lower confidence interval

From: Results

Cover of Drug Class Review: Alzheimer's Drugs
Drug Class Review: Alzheimer's Drugs: Final Report [Internet].
Hansen RA, Gartlehner G, Kaufer DJ, et al.
Portland (OR): Oregon Health & Science University; 2006 Jun.
Copyright © 2006, Oregon Health & Science University, Portland, Oregon.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.