TABLE 5-1Elements of the OECD SIDS

Data Elements Comments
Physical-chemical properties
       Melting point
       Boiling point
       Relative density Required for inorganic chemicals and should be provided if readily available for organic chemicals.
       Vapor pressure
       Partition coefficient: n-octanol/water
       Water solubility
       Dissociation constant For substances normally capable of dissociation.
       Oxidation-reduction potential Required for inorganic chemicals; may be required for certain organic chemicals.
Environmental fate
       Stability in water Not required for classes of chemicals whose molecular structure does not possess functional groups subject to hydrolysis or that are generally recognized to be resistant to hydrolysis. In these cases, a qualitative statement can be provided.
       Transport and distribution between environmental compartments including distribution pathways Including Henry’s law constant, aerosolization, volatilization, soil adsorption, and desorption, based on experimental data or, if not available or appropriate, calculated using structure-activity relationships.
       Aerobic biodegradability
Environmental toxicology
       Acute toxicity to fish
       Acute toxicity to daphnia
       Toxicity to algae
       Chronic toxicity Necessity determined based on physical-chemical properties of the chemical. Any new data required should be collected using the most sensitive species (fish, daphnia, or algae) within limitations of the chemical properties.
       Terrestrial toxicity The need for testing will normally be addressed at the post-SIDS stage. However, if significant exposure is expected or identified in the terrestrial environment (soil), appropriate terrestrial toxicity tests should be considered at the SIDS level. Taking into account animal
welfare considerations, the need for avian toxicity testing should be considered only at the post-SIDS stage.
Mammalian toxicology
       Acute toxicity By oral route, dermal route, or inhalation; required only on the most relevant route of exposure
       Repeated dose toxicity The protocol for new studies should specify the use of the most relevant route of exposure.
       Genetic toxicity Two end points required, generally point mutation and chromosomal aberrations.
       Reproductive toxicity Requires data to assess fertility and developmental toxicity.
       Experience with human exposure If available.

Source: Adapted from OECD 2006. Reprinted with permission; 2006, Organisation for Economic Co-operation and Development.

From: 5, Application to Hazard Screening

Cover of Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment
Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment.
National Research Council (US) Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology.
Washington (DC): National Academies Press (US); 2007.
Copyright © 2007, National Academy of Sciences.

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