Appendix DApplicability and Quality Tables

Publication Details

Table 1. Key Question 1—Applicability

Table 2. Key Question 2—Applicability

Table 3. Key Question 3—Applicability

Table 4. Key Question 4—Applicability

Table 5. The Cochrane Risk of Bias Tool for Randomized Controlled Trials

Table 6. Quality ratings for randomized control trials

Table 7. Quality ratings for cohort studies (including case series, cross-sectional, uncontrolled and nonrandomized trials)

Table 8. Quality ratings for case-control studies

Martin JA, Hamilton BE, Sutton PD, et al. Births: Final Data for 2008. National Vital Statistics Reports. 2010 December 8;59(1):1–72. Released. [PubMed: 22145497]
Abboud TK, Swart F, Zhu J, et al. Desflurane analgesia for vaginal delivery. Acta Anaesthesiol Scand. 1995 Feb;39(2):259–61. [PubMed: 7793195]
Abboud TK, Gangolly J, Mosaad P, et al. Isoflurane in obstetrics. Anesth Analg. 1989 Mar;68(3):388–91. [PubMed: 2919779]
Abboud TK, Shnider SM, Wright RG, et al. Enflurane analgesia in obstetrics. Anesth Analg. 1981 Mar;60(3):133–7. [PubMed: 7193989]
Arora S, Tunstall M, Ross J. Self-administered mixture of Entonox and isoflurane in labour. Int J Obstet Anesth. 1992 Sep;1(4):199–202. [PubMed: 15636826]
Bergsjo P, Lindbaek E. Comparison between nitrous oxide and methoxyflurane for obstetrical analgesia. Acta Obstet Gynecol Scand. 1971;50(3):285–90. [PubMed: 4942713]
Carstoniu J, Levytam S, Norman P, et al. Nitrous oxide in early labor. Safety and analgesic efficacy assessed by a double-blind, placebo-controlled study. Anesthesiology. 1994 Jan;80(1):30–5. [PubMed: 8291726]
Chia YT, Arulkumaran S, Chua S, et al. Effectiveness of transcutaneous electric nerve stimulator for pain relief in labour. Asia Oceania J Obstet Gynaecol. 1990 Jun;16(2):145–51. [PubMed: 2378593]
Constantine G, Luesley DM, O'Connor A, et al. The use of Entonox in conjunction with a rebreathing humidifier. J Obstet Gynaecol. 1989;10(1):23–25.
Einarsson S, Stenqvist O, Bengtsson A, et al. Gas kinetics during nitrous oxide analgesia for labour. Anaesthesia. 1996 May;51(5):449–52. [PubMed: 8694158]
Jones PL, Rosen M, Mushin WW, et al. Methoxyflurane and nitrous oxide as obstetric analgesics. I. A comparison by continuous administration. Br Med J. 1969 Aug 2;3(5665):255–9. [PMC free article: PMC1984038] [PubMed: 4895338]
Jones PL, Rosen M, Mushin WW, et al. Methoxyflurane and nitrous oxide as obstetric analgesics. II. A comparison by self-administered intermittent inhalation. Br Med J. 1969 Aug 2;3(5665):259–62. [PMC free article: PMC1984080] [PubMed: 4895339]
McGuinness C, Rosen M. Enflurane as an analgesic in labour. Anaesthesia. 1984 Jan;39(1):24–6. [PubMed: 6696214]
McLeod DD, Ramayya GP, Tunstall ME. Self-administered isoflurane in labour. A comparative study with Entonox. Anaesthesia. 1985 May;40(5):424–6. [PubMed: 4014617]
Clinical trials of different concentrations of oxygen and nitrous oxide for obstetric analgesia. Report to the Medical Research Council of the Committee on Nitrous Oxide and Oxygen Analgesia in Midwifery. Br Med J. 1970 Mar 21;1(5698):709–13. [PMC free article: PMC1699836] [PubMed: 5440545]
Phillips TJ, Macdonald RR. Comparative effect of pethidine, trichloroethylene, and Entonox on fetal and neonatal acid-base and PO2. Br Med J. 1971 Sep 4;3(5774):558–60. [PMC free article: PMC1798856] [PubMed: 5571451]
Rosen M, Latto P, Asscher AW. Kidney function after methoxyflurane analgesia during labour. Br Med J. 1972 Jan 8;1(5792):81–3. [PMC free article: PMC1789263] [PubMed: 5007074]
Talebi H, Nourozi A, Jamilian M, et al. Entonox for labor pain: a randomized placebo controlled trial. Pak J Biol Sci. 2009 Sep 1;12(17):1217–21. [PubMed: 19943458]
Westling F, Milsom I, Zetterstrom H, et al. Effects of nitrous oxide/oxygen inhalation on the maternal circulation during vaginal delivery. Acta Anaesthesiol Scand. 1992 Feb;36(2):175–81. [PubMed: 1549939]
Yeo ST, Holdcroft A, Yentis SM, et al. Analgesia with sevoflurane during labour: ii. Sevoflurane compared with Entonox for labour analgesia. Br J Anaesth. 2007 Jan;98(1):110–5. [PubMed: 17158129]
Ahlborg G Jr., Axelsson G, Bodin L. Shift work, nitrous oxide exposure and subfertility among Swedish midwives. Int J Epidemiol. 1996 Aug;25(4):783–90. [PubMed: 8921457]
Arfeen Z, Armstrong PJ, Whitfield A. The effects of Entonox and epidural analgesia on arterial oxygen saturation of women in labour. Anaesthesia. 1994 Jan;49(1):32–4. [PubMed: 8311209]
Arthurs GJ, Rosen M. Self-administered intermittent nitrous oxide analgesia for labour. Enhancement of effect with continuous nasal inhalation of 50 per cent nitrous oxide (Entonox) Anaesthesia. 1979 Apr;34(4):301–9. [PubMed: 378022]
Axelsson G, Ahlborg G Jr., Bodin L. Shift work, nitrous oxide exposure, and spontaneous abortion among Swedish midwives. Occup Environ Med. 1996 Jun;53(6):374–8. [PMC free article: PMC1128492] [PubMed: 8758031]
Beppu K. Transmission of the anesthetic agents through the placenta in painless delivery and their effects on newborn infants. Keio J Med. 1968 Jun;17(2):81–107. [PubMed: 5727834]
Bodin L, Axelsson G, Ahlborg G Jr. The association of shift work and nitrous oxide exposure in pregnancy with birth weight and gestational age. Epidemiology. 1999 Jul;10(4):429–36. [PubMed: 10401879]
Clark RB, Cooper JO, Brown WE, et al. An evaluation of methoxyflurane analgesia and anesthesia for obstetrics. South Med J. 1968 Jul;61(7):687–91. [PubMed: 5664516]
Deckardt R, Fembacher PM, Schneider KT, et al. Maternal arterial oxygen saturation during labor and delivery: pain-dependent alterations and effects on the newborn. Obstet Gynecol. 1987 Jul;70(1):21–5. [PubMed: 3601266]
Harrison RF, Shore M, Woods T, et al. A comparative study of transcutaneous electrical nerve stimulation (TENS), entonox, pethidine + promazine and lumbar epidural for pain relief in labor. Acta Obstet Gynecol Scand. 1987;66(1):9–14. [PubMed: 3300138]
Harrison RF, Cullen R. A comparative study of the behaviour of the neonate following various forms of maternal intrapartum analgesia and anaesthesia. Ir J Med Sci. 1986;155(1):12–18. [PubMed: 3700061]
Henderson KA, Matthews IP, Adisesh A, et al. Occupational exposure of midwives to nitrous oxide on delivery suites. Occup Environ Med. 2003 Dec;60(12):958–61. [PMC free article: PMC1740444] [PubMed: 14634189]
Henry A, Nand SL. Intrapartum pain management at the Royal Hospital for Women. Aust N Z J Obstet Gynaecol. 2004 Aug;44(4):307–13. [PubMed: 15282001]
Holdcroft A, Morgan M. An assessment of the analgesic effect in labour of pethidine and 50 per cent nitrous oxide in oxygen (Entonox) J Obstet Gynaecol Br Commonw. 1974 Aug;81(8):603–7. [PubMed: 4424256]
Landon MJ, Creagh-Barry P, McArthur S, et al. Influence of vitamin B12 status on the inactivation of methionine synthase by nitrous oxide. Br J Anaesth. 1992 Jul;69(1):81–6. [PubMed: 1637609]
Leong EW, Sivanesaratnam V, Oh LL, et al. Epidural analgesia in primigravidae in spontaneous labour at term: a prospective study. J Obstet Gynaecol Res. 2000 Aug;26(4):271–5. [PubMed: 11049237]
Marx GF, Joshi CW, Orkin LR. Placental transmission of nitrous oxide. Anesthesiology. 1970 May;32(5):429–32. [PubMed: 5445031]
McAneny T, Doughty A. Self-administered nitrous-oxide/oxygen analgesia in obstetrics. Anaesthesia. 1963;18(4):488–497. 1963. [PubMed: 14071377]
Mills GH, Singh D, Longan M, et al. Nitrous oxide exposure on the labour ward. Int J Obstet Anesth. 1996 Jul;5(3):160–4. [PubMed: 15321342]
Morgan B, Bulpitt CJ, Clifton P, et al. Effectiveness of pain relief in labour: survey of 1000 mothers. Br Med J (Clin Res Ed) 1982 Sep 11;285(6343):689–90. [PMC free article: PMC1499875] [PubMed: 6809188]
Murphy JF, Dauncey M, Rees GAD. Obstetric analgesia, anaesthesia and the Apgar score. Anaesthesia. 1984;39(8):760–763. [PubMed: 6476311]
Newton C, Fitz-Henry J, Bogod D. The occupational exposure of midwives to nitrous oxide - a comparison between two labour suites. Int J Obstet Anesth. 1999 Jan;8(1):7–10. [PubMed: 15321169]
Paech MJ. The King Edward Memorial Hospital 1,000 mother survey of methods of pain relief in labour. Anaesth Intensive Care. 1991 Aug;19(3):393–9. [PubMed: 1767909]
Ranta P, Spalding M, Kangas-Saarela T, et al. Maternal expectations and experiences of labour pain - options of 1091 Finnish parturients. Acta Anaesthesiol Scand. 1995;39(1):60–66. [PubMed: 7725885]
Ranta P, Jouppila P, Spalding M, et al. Parturients' assessment of water blocks, pethidine, nitrous oxide, paracervical and epidural blocks in labour. Int J Obstet Anesth. 1994;3(4):193–198. [PubMed: 15636949]
Reed PN, Colquhoun AD, Hanning CD. Maternal oxygenation during normal labour. Br J Anaesth. 1989 Mar;62(3):316–8. [PubMed: 2930673]
Rosen M, Mushin WW, Jones PL, et al. Field trial of methoxyflurane, nitrous oxide, and trichloroethylene as obstetric analgesics. Br Med J. 1969 Aug 2;3(5665):263–7. [PMC free article: PMC1984095] [PubMed: 4895340]
Ross JA, Tunstall ME, Campbell DM, et al. The use of 0.25% isoflurane premixed in 50% nitrous oxide and oxygen for pain relief in labour. Anaesthesia. 1999 Dec;54(12):1166–72. [PubMed: 10594414]
Smith BE, Moya F. Inhalational analgesia with methoxyflurane for vaginal delivery. South Med J. 1968 Apr;61(4):386–90. [PubMed: 5644074]
Soyannwo OA. Self-administered Entonox (50% nitrous oxide in oxygen) in labour: report of the experience in Ibadan. Afr J Med Med Sci. 1985 Mar-Jun;14(1-2):95–8. [PubMed: 2994447]
Stirk P, Staines J, Brown DW. Maternal diamorphine administration during labour: the effect on neonate admissions to NNU. J Neonatal Nurs. 2002;8(2):56–7.
Waldenstrom U, Irestedt L. Obstetric pain relief and its association with remembrance of labor pain at two months and one year after birth. J Psychosom Obstet Gynaecol. 2006 Sep;27(3):147–56. [PubMed: 17214449]
Waldenstrom U. Experience of labor and birth in 1111 women. J Psychosom Res. 1999 Nov;47(5):471–82. [PubMed: 10624845]
Westberg H, Egelrud L, Ohlson CG, et al. Exposure to nitrous oxide in delivery suites at six Swedish hospitals. Int Arch Occup Environ Health. 2008;81(7):829–836. [PubMed: 17952690]
Waldenstrom U, Bergman V, Vasell G. The complexity of labor pain: Experiences of 278 women. J Psychosom Obstet Gynaecol. 1996;17(4):215–228. [PubMed: 8997688]
Zelcer J, Owers H, Paull JD. A controlled oximetric evaluation of inhalational, opioid and epidural analgesia in labour. Anaesth Intensive Care. 1989 Nov;17(4):418–21. [PubMed: 2596676]
Jacobson B, Nyberg K, Gronbladh L, et al. Opiate addiction in adult offspring through possible imprinting after obstetric treatment. BMJ. 1990 Nov 10;301(6760):1067–70. [PMC free article: PMC1664218] [PubMed: 2249068]
Jacobson B, Nyberg K, Eklund G, et al. Obstetric pain medication and eventual adult amphetamine addiction in offspring. Acta Obstet Gynecol Scand. 1988;67(8):677–82. [PubMed: 3250180]
Nyberg K, Allebeck P, Eklund G, et al. Socio-economic versus obstetric risk factors for drug addiction in offspring. Br J Addict. 1992 Dec;87(12):1669–76. [PubMed: 1490081]
Zack M, Adami HO, Ericson A. Maternal and perinatal risk factors for childhood leukemia. Cancer Res. 1991 Jul 15;51(14):3696–701. [PubMed: 2065325]