Figure 13.4. Segmental restriction of neural crest cells and motor neurons by the ephrin proteins of the sclerotome.

Figure 13.4

Segmental restriction of neural crest cells and motor neurons by the ephrin proteins of the sclerotome. (A) Negative correlation between regions of ephrin in the sclerotome (dark blue stain, left) and neural crest cell migration (green HNK-1 stain, right). (B) When neural crest cells are plated on fibronectin-containing matrices with alternating stripes of ephrin, they bind to those regions lacking ephrin. (C) Composite scheme showing migration of spinal cord neural crest cells and motor neurons through the ephrin-deficient anterior regions of the sclerotomes. (For clarity, the neural crest cells and motor neurons are each depicted on only one side of the spinal cord.) (A and B from Krull et al. 1997; C after O'Leary and Wilkinson 1999.)

From: The Neural Crest

Cover of Developmental Biology
Developmental Biology. 6th edition.
Gilbert SF.
Sunderland (MA): Sinauer Associates; 2000.
Copyright © 2000, Sinauer Associates.

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