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Burr JM, Botello-Pinzon P, Takwoingi Y, et al. Surveillance for Ocular Hypertension: An Evidence Synthesis and Economic Evaluation. Southampton (UK): NIHR Journals Library; 2012 Jun. (Health Technology Assessment, No. 16.29.)

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Surveillance for Ocular Hypertension: An Evidence Synthesis and Economic Evaluation.

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Appendix 10Systematic review of economic evaluations of surveillance strategies for ocular hypertension: methods and results (Chapter 8)


The aim was to systematically review the available evidence on the cost-effectiveness of strategies for monitoring individuals with OHT who are at risk of developing glaucoma and to inform the methodology of the proposed economic evaluation. Studies that considered the UK NHS perspective were of particular interest.


Search strategy for identification of published reports

Extensive sensitive electronic searches were conducted to identify reports of published and ongoing studies of economic evaluations of SOH. In addition, reference lists of retrieved papers were scrutinised to identify additional potentially relevant studies.

The databases searched were MEDLINE (1950 to October Week 4 2010), EMBASE (1980 to Week 41 2010), MEDLINE In-Process & Other Non-Indexed Citations (25 October 2010), Health Management Information Consortium (1979 to October 2010), the NHS Economic Evaluations Database (NHS EED) (October 2010) and the HTA database for relevant evidence syntheses (October 2010).

Full details of the search strategies used are reproduced in Appendix 1.

Selection process

Inclusion criteria

  • Interventions: surveillance strategies of patients with OHT.
  • Study population: adults.
  • Study type: full economic evaluations – studies that compare the costs and outcomes of two or more strategies for monitoring individuals with OHT. An eligible strategy can include a situation in which no active or organised monitoring service is available.
  • Outcomes: studies had to include either costs (regardless of the way that these were estimated) or effects (regardless of the way that these were estimated).


Two reviewers (KB, AA-B) independently scanned titles and abstracts for inclusion of potentially relevant studies. Full-text copies of all potentially relevant reports were retrieved. The full-text reports were assessed against the inclusion criteria by two reviewers independently (AT, AA-B). Any disagreements were resolved by consensus or arbitration by a third party.


In total, 161 papers were identified from the initial search. Of these, 11 were selected as potentially relevant and full-text copies were retrieved. On screening the full text of these retrieved studies; however, no studies were identified that fulfilled the inclusion criteria for the systematic review. A list of excluded full-text studies can be found in Appendix 2. A flow diagram of the selection process is shown in Figure 71.

FIGURE 71. Flow diagram of the selection process.


Flow diagram of the selection process.

© 2012, Crown Copyright.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK100057


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